In:
Diabetic Medicine, Wiley, Vol. 39, No. 3 ( 2022-03)
Abstract:
This study aimed to evaluate the ability of HbA 1c combined with glycated albumin (GA) or 1,5‐anhydroglucitol (1,5‐AG) to detect diabetes in residents of Jiangsu, China. Methods The oral glucose tolerance test (OGTT) was performed on 2184 people in Jiangsu. HbA 1c , GA, 1,5‐AG and other serum biochemical parameters were measured. Receiver operating characteristic curves were plotted to determine the optimal thresholds of HbA 1c , GA and 1,5‐AG according to the Youden index. Results (1) The optimal thresholds of HbA 1c , GA and 1,5‐AG for the screening of diabetes were ≥45 mmol/mol (6.3%), ≥13.0% and ≤23.0 μg/ml, respectively. (2) The sensitivities of HbA 1c combined with GA and 1,5‐AG were both 85%, higher than that of HbA 1c (70%, p 〈 0.001). Conclusions This study is suitable for cases where plasma glucose is unavailable. Among the residents of Jiangsu, HbA 1c combined with GA or 1,5‐AG can improve the sensitivity of diabetes screening, reduce the miss rate and save the use of OGTT. GA and 1,5‐AG are superior in individuals with mild glucose metabolism disorder. GA enhances the detection of diabetes in the nonobese, and 1,5‐AG enhances the detection in those with hyperuricaemia.
Type of Medium:
Online Resource
ISSN:
0742-3071
,
1464-5491
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2019647-7
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