In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-16), p. e0244417-
Abstract:
Self-sampling for SARS-CoV-2 would significantly raise testing capacity and reduce healthcare worker (HCW) exposure to infectious droplets personal, and protective equipment (PPE) use. Methods We conducted a diagnostic accuracy study where subjects with a confirmed diagnosis of COVID-19 (n = 401) and healthy volunteers (n = 100) were asked to self-swab from their oropharynx and mid-turbinate (OPMT), and self-collect saliva. The results of these samples were compared to an OPMT performed by a HCW in the same patient at the same session. Results In subjects confirmed to have COVID-19, the sensitivities of the HCW-swab, self-swab, saliva, and combined self-swab plus saliva samples were 82.8%, 75.1%, 74.3% and 86.5% respectively. All samples obtained from healthy volunteers were tested negative. Compared to HCW-swab, the sensitivities of a self-swab sample and saliva sample were inferior by 8.7% (95%CI: 2.4% to 15.0%, p = 0.006) and 9.5% (95%CI: 3.1% to 15.8%, p = 0.003) respectively. The combined detection rate of self-swab and saliva had a sensitivity of 2.7% (95%CI: -2.6% to 8.0%, p = 0.321). The sensitivity of both the self-collection methods are higher when the Ct value of the HCW swab is less than 30. The specificity of both the self-swab and saliva testing was 100% (95% CI 96.4% to 100%). Conclusion Our study provides evidence that sensitivities of self-collected OPMT swab and saliva samples were inferior to a HCW swab, but they could still be useful testing tools in the appropriate clinical settings.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0244417
DOI:
10.1371/journal.pone.0244417.g001
DOI:
10.1371/journal.pone.0244417.g002
DOI:
10.1371/journal.pone.0244417.t001
DOI:
10.1371/journal.pone.0244417.t002
DOI:
10.1371/journal.pone.0244417.t003
DOI:
10.1371/journal.pone.0244417.t004
DOI:
10.1371/journal.pone.0244417.t005
DOI:
10.1371/journal.pone.0244417.t006
DOI:
10.1371/journal.pone.0244417.t007
DOI:
10.1371/journal.pone.0244417.s001
DOI:
10.1371/journal.pone.0244417.s002
DOI:
10.1371/journal.pone.0244417.s003
DOI:
10.1371/journal.pone.0244417.s004
DOI:
10.1371/journal.pone.0244417.s005
DOI:
10.1371/journal.pone.0244417.r001
DOI:
10.1371/journal.pone.0244417.r002
DOI:
10.1371/journal.pone.0244417.r003
DOI:
10.1371/journal.pone.0244417.r004
DOI:
10.1371/journal.pone.0244417.r005
DOI:
10.1371/journal.pone.0244417.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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