In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 30, No. 15_suppl ( 2012-05-20), p. e14575-e14575
Abstract:
e14575 Background: Gastric Cancer (GC) is the second leading cause of cancer death in Shanghai,and the overall treatment response remains poor. This study aimed to describe overall survival and identify prognostic factors for survival among GC patients (pts) after radical resection. Methods: Clinical data of 1594 GC pts (Shanghai residents) who had undergone R0 or R1 resection in Zhongshan hospital, January 2003 to June 2010, were analyzed. Potential prognostic factors including demographic and tumor characteristics were collected. Survival was calculated by the Kaplan-Meier method and Log-rank test was used to determine statistical significance. Prognostic factors were analyzed using Cox regression multivariate analysis. Results: Overall 5-year cumulative survival for all pts was 55.8%. The 5-year cumulative survival by TNM stage I, II, III, and IV (classified using AJCC 7th edition staging system) were 93.8%, 72.7%, 33.3%, and 12.7%, respectively. The distribution of pts by AJCC stage I-IV was 22.5%, 23.1%, 51.7% and 2.8% respectively. In univariate analyses, gender and the number of lymph nodes removed was not associated with survival (p 〉 0.05). However, age, tumor differentiation, tumor site, lympahtic/venous invasion, depth of infiltration, presence of lymph node metastasis, and presence of distant metastasis were related to survival (p 〈 0.05). In multivariate Cox regression model analysis, age (p 〈 0.001), tumor site (p=0.004), lymphatic/venous invasion (p 〈 0.001), TNM stage(p 〈 0.001) were independent prognosticators. Among pts with TNM stage III , number of lymph nodes removed was also an independent prognostic factor (p 〈 0.001). Conclusions: Age, tumor site, lymphatic/venous invasion, TNM stage in all patients, and the number of lymph nodes removed in TNM stage III patients, were independent prognostic factors. GC remains a significant unmet medical need in China and effective therapies are urgently needed.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2012.30.15_suppl.e14575
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2012
detail.hit.zdb_id:
2005181-5
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