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Cotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIV

Ku, Stephane Wen‐Wei ; Jiamsakul, Awachana ; Joshi, Kedar ; [et al.]

Wiley ; 2019

In: Journal of the International AIDS Society Vol. 22, No. 3 ( 2019-03)

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In: Journal of the International AIDS Society, Wiley, Vol. 22, No. 3 ( 2019-03)

Abstract: Cotrimoxazole ( CTX ) is recommended as prophylaxis against Pneumocystis jiroveci pneumonia, malaria and other serious bacterial infections in HIV ‐infected patients. Despite its in vitro activity against Mycobacterium tuberculosis , the effects of CTX preventive therapy on tuberculosis ( TB ) remain unclear. Methods Adults living with HIV enrolled in a regional observational cohort in Asia who had initiated combination antiretroviral therapy ( cART ) were included in the analysis. Factors associated with new TB diagnoses after cohort entry and survival after cART initiation were analysed using Cox regression, stratified by site. Results A total of 7355 patients from 12 countries enrolled into the cohort between 2003 and 2016 were included in the study. There were 368 reported cases of TB after cohort entry with an incidence rate of 0.99 per 100 person‐years (/100 pys). Multivariate analyses adjusted for viral load ( VL ), CD 4 count, body mass index ( BMI ) and cART duration showed that CTX reduced the hazard for new TB infection by 28% ( HR 0.72, 95% CI l 0.56, 0.93). Mortality after cART initiation was 0.85/100 pys, with a median follow‐up time of 4.63 years. Predictors of survival included age, female sex, hepatitis C co‐infection, TB diagnosis, HIV VL , CD 4 count and BMI. Conclusions CTX was associated with a reduction in the hazard for new TB infection but did not impact survival in our Asian cohort. The potential preventive effect of CTX against TB during periods of severe immunosuppression should be further explored.

Type of Medium: Online Resource

ISSN: 1758-2652 , 1758-2652

URL: Issue

URL: Article

DOI: 10.1002/jia2.2019.22.issue-3

DOI: 10.1002/jia2.25264

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 2467110-1

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Virological failure and treatment switch after ART initiation among people living with HIV with and without routine viral load monitoring in Asia

Teeraananchai, Sirinya ; Law, Matthew ; Boettiger, David ; [et al.]

Wiley ; 2022

In: Journal of the International AIDS Society Vol. 25, No. 8 ( 2022-08)

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In: Journal of the International AIDS Society, Wiley, Vol. 25, No. 8 ( 2022-08)

Abstract: Viral load (VL) testing is still challenging to monitor treatment responses of antiretroviral therapy (ART) for HIV treatment programme in Asia. We assessed the association between routine VL testing and virological failure (VF) and determine factors associated with switching to second‐line regimen. Methods Among 21 sites from the TREAT Asia HIV Observational Database (TAHOD), people living with HIV (PLHIV) aged ≥18 years initiating ART from 2003 to 2021 were included. We calculated the average number of VL tests per patient per year between the date of ART initiation and the most recent visit. If the median average number of VL tests was ≥ 0.80 per patient per year, the site was classified as a routine VL site. A site with a median 〈 0.80 was classified into the non‐routine VL sites. VF was defined as VL ≥1000 copies/ml during first‐line therapy. Factors associated with VF were analysed using generalized estimating equations with Poisson distribution. Results Of 6277 PLHIV starting ART after 2003, 3030 (48%) were from 11 routine VL testing sites and 3247 (52%) were from 10 non‐routine VL testing sites. The median follow‐up was 9 years (IQR 5–13). The median age was 35 (30–42) years; 68% were male and 5729 (91%) started non‐nucleoside reverse‐transcriptase inhibitor‐based regimen. The median pre‐ART CD4 count in PLHIV from routine VL sites was lower compared to non‐routine VL sites (144 vs. 156 cells/mm 3 , p 〈 0.001). Overall, 1021 subsequent VF at a rate of 2.15 (95% CI 2.02–2.29) per 100 person‐years (PY). VF was more frequent at non‐routine VL sites (adjusted incidence rate ratio 2.85 [95% CI 2.27–3.59]) compared to routine VL sites. Other factors associated with an increased rate of VF were age 〈 50 years and CD4 count 〈 350 cells/mm 3 . A total of 817 (13%) patients switched to second‐line regimen at a rate of 1.44 (95% CI 1.35–1.54) per 100 PY. PLHIV at routine VL monitoring sites were at higher risk of switching than those at non‐routine VL sites (adjusted sub‐hazard ratio 1.78 95% CI [1.17–2.71]). Conclusions PLHIV from non‐routine VL sites had a higher incidence of persistent VF and a low switching regimen rate, reflecting possible under‐utilized VL testing.

Type of Medium: Online Resource

ISSN: 1758-2652 , 1758-2652

URL: Issue

URL: Article

DOI: 10.1002/jia2.v25.8

DOI: 10.1002/jia2.25989

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2467110-1

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2．HIV感染症診療

Tanuma, Junko ; Oka, Shinichi

Japanese Society of Internal Medicine ; 2010

In: Nihon Naika Gakkai Zasshi Vol. 99, No. 11 ( 2010), p. 2740-2745

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In: Nihon Naika Gakkai Zasshi, Japanese Society of Internal Medicine, Vol. 99, No. 11 ( 2010), p. 2740-2745

Type of Medium: Online Resource

ISSN: 0021-5384 , 1883-2083

URL: Article

DOI: 10.2169/naika.99.2740

Language: English

Publisher: Japanese Society of Internal Medicine

Publication Date: 2010

detail.hit.zdb_id: 2455995-7

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Interim FDG-PET/CT as a predictor of prognosis for HIV-related malignant lymphoma: Preliminary study

Minamimoto, Ryogo ; Tanuma, Junko ; Morooka, Miyako ; [et al.]

Sciedu Press ; 2013

In: Journal of Solid Tumors Vol. 3, No. 2 ( 2013-01-09)

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In: Journal of Solid Tumors, Sciedu Press, Vol. 3, No. 2 ( 2013-01-09)

Type of Medium: Online Resource

ISSN: 1925-4075 , 1925-4067

URL: Article

DOI: 10.5430/jst.v3n2p1

Language: Unknown

Publisher: Sciedu Press

Publication Date: 2013

detail.hit.zdb_id: 2635428-7

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Global Efforts against HIV Epidemic and HIV Vaccine Development

Tanuma, Junko

Japanese Society of Tropical Medicine ; 2014

In: Tropical Medicine and Health Vol. 42, No. 2SUPPLEMENT ( 2014), p. S91-S92

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In: Tropical Medicine and Health, Japanese Society of Tropical Medicine, Vol. 42, No. 2SUPPLEMENT ( 2014), p. S91-S92

Type of Medium: Online Resource

ISSN: 1348-8945 , 1349-4147

Uniform Title: HIV予防のグローバル戦略とワクチン開発への期待

URL: Article

DOI: 10.2149/tmh.2014-S13

Language: English , Japanese

Publisher: Japanese Society of Tropical Medicine

Publication Date: 2014

detail.hit.zdb_id: 2209835-5

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Influence of maternal use of tenofovir disoproxil fumarate or zidovudine in Vietnamese pregnant women with HIV on infant growth, renal function, and bone health

Kinai, Ei ; Nguyen, Hoai Dung Thi ; Do, Ha Quan ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS ONE Vol. 16, No. 4 ( 2021-4-29), p. e0250828-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-29), p. e0250828-

Abstract: Tenofovir disoproxil fumarate (TDF) is still widely prescribed for human immunodeficiency virus (HIV)-infected pregnant women, despite its renal and bone toxicity. Although TDF-exposed infants often show transient growth impairment, it is not clear whether maternal TDF causes infantile rickets via maternal/fetal renal dysfunction in Asian populations. This prospective observational study was conducted in Vietnam and involved pregnant HIV-infected women treated with TDF-based regimen (TDF group) or zidovudine-based regimen (AZT-group). At birth, 3, 12, and 18 months of age, and included body length, weight, head circumference, serum alkaline phosphatase (ALP), creatinine, calcium, phosphorus, urine-β2-microglobulin (U-BMG), percentage of tubular reabsorption of phosphate (%TRP), and radiographic wrist score for rickets. Age-adjusted multivariate linear regression analysis evaluated the association of TDF/AZT use during pregnancy with fetal renal function and bone health. The study included 63 mother-infant pairs (TDF group = 53, AZT group = 10). In the mothers, detectable U-BMG ( 〉 252 μg/L) was observed more frequently in the TDF- than AZT group (89 vs 50%, p 〈 0.001), but other renal/bone parameters were similar. In infants, maternal TDF use was not associated with growth impairment, renal dysfunction, or abnormal bone findings, but with a slightly higher ALP levels (p = 0.019). However, shorter length was associated with maternal AZT (p = 0.021), and worse radiographic scores were associated with LPV/r (p = 0.024). In Vietnamese population, TDF usage during pregnancy was not associated with infant transient rickets, growth impairment, or renal dysfunction, despite mild maternal tubular impairment. Maternal AZT and LPV/r influenced infant growth and bone health, though further studies are needed to confirm this finding.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0250828

DOI: 10.1371/journal.pone.0250828.g001

DOI: 10.1371/journal.pone.0250828.g002

DOI: 10.1371/journal.pone.0250828.g003

DOI: 10.1371/journal.pone.0250828.t001

DOI: 10.1371/journal.pone.0250828.t002

DOI: 10.1371/journal.pone.0250828.t003

DOI: 10.1371/journal.pone.0250828.t004

DOI: 10.1371/journal.pone.0250828.s001

DOI: 10.1371/journal.pone.0250828.s002

DOI: 10.1371/journal.pone.0250828.s003

DOI: 10.1371/journal.pone.0250828.r001

DOI: 10.1371/journal.pone.0250828.r002

DOI: 10.1371/journal.pone.0250828.r003

DOI: 10.1371/journal.pone.0250828.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2267670-3

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Epstein-Barr Viral Load in Cerebrospinal Fluid as a Diagnostic Marker of Central Nervous System Involvement of AIDS-related Lymphoma

Yanagisawa, Kunio ; Tanuma, Junko ; Hagiwara, Shotaro ; [et al.]

Japanese Society of Internal Medicine ; 2013

In: Internal Medicine Vol. 52, No. 9 ( 2013), p. 955-959

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In: Internal Medicine, Japanese Society of Internal Medicine, Vol. 52, No. 9 ( 2013), p. 955-959

Type of Medium: Online Resource

ISSN: 0918-2918 , 1349-7235

URL: Article

DOI: 10.2169/internalmedicine.52.9088

RVK:

XA 49642

Language: English

Publisher: Japanese Society of Internal Medicine

Publication Date: 2013

detail.hit.zdb_id: 2202453-0

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Incidence of AIDS-Defining Opportunistic Infections and Mortality during Antiretroviral Therapy in a Cohort of Adult HIV-Infected Individuals in Hanoi, 2007-2014

Tanuma, Junko ; Lee, Kyu Ha ; Haneuse, Sebastien ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS ONE Vol. 11, No. 3 ( 2016-3-3), p. e0150781-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 3 ( 2016-3-3), p. e0150781-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0150781

DOI: 10.1371/journal.pone.0150781.g001

DOI: 10.1371/journal.pone.0150781.g002

DOI: 10.1371/journal.pone.0150781.g003

DOI: 10.1371/journal.pone.0150781.t001

DOI: 10.1371/journal.pone.0150781.t002

DOI: 10.1371/journal.pone.0150781.t003

DOI: 10.1371/journal.pone.0150781.t004

DOI: 10.1371/journal.pone.0150781.t005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2267670-3

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Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Related Mortality

Pasayan, Mark Kristoffer ; Mationg, Mary Lorraine ; Boettiger, David ; [et al.]

Oxford University Press (OUP) ; 2017

In: Open Forum Infectious Diseases Vol. 4, No. suppl_1 ( 2017-10-01), p. S59-S59

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In: Open Forum Infectious Diseases, Oxford University Press (OUP), Vol. 4, No. suppl_1 ( 2017-10-01), p. S59-S59

Abstract: Mycobacterium avium–intracelllulare complex (MAC) prophylaxis is recommended for patients with CD4 counts of & lt; 50 cells/mm3. With the significant decrease in incidence of disseminated MAC infection and the effective immune recovery due to the availability of combination antiretroviral therapy (ART), the benefits of giving MAC prophylaxis were investigated. This study examined the impact of macrolide prophylaxis on AIDS-defining conditions and HIV-associated mortality in a cohort of HIV-infected patients on ART. Methods TREAT Asia HIV Observational Database (TAHOD) patients aged ≥18 years with a CD4 count & lt; 50 cells/mm3 at ART initiation were included. The effect of macrolide prohylaxis on HIV-associated mortality or an AIDS event (as a combined outcome) and HIV-associated mortality alone were evaluated using competing risk regression. Sensitivity analysis was conducted to assess whether results were consistent in patients with a CD4 & lt; 100 cells/mm3 at ART initiation. Results Of 1,345 eligible patients (78% male with median age at ART initiation of 34.8 years), 10.6% received macrolide prophylaxis. The rates of the combined outcome and HIV-associated mortality per 100 patient years were 7.35 [95% confidence interval (CI): 6.04–8.95] and 3.14 (95% CI: 2.35–4.19), respectively. After adjusting for possible confounders, macrolide use was associated with a significantly decreased risk of HIV-associated mortality (HR 0.10, 95% CI: 0.01–0.80, P = 0.031) but not the combined outcome (HR 0.86, 95% CI: 0.32–2.229, P = 0.764). Sensitivity analyses showed that, among patients with a CD4 & lt; 100 cells/ mm3 at ART initiation, these results were consistent. Conclusion Macrolide prophylaxis is associated with significantly improved survival among Asian HIV-infected patients with very low CD4 cell counts. The benefits of giving macrolide prophylaxis remain despite the availability of effective ART. Disclosures All authors: No reported disclosures.

Type of Medium: Online Resource

ISSN: 2328-8957

URL: Article

DOI: 10.1093/ofid/ofx162.139

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2017

detail.hit.zdb_id: 2757767-3

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Non-AIDS-defining hematological malignancies in HIV-infected patients : an epidemiological study in Japan

Hagiwara, Shotaro ; Yotsumoto, Mihoko ; Odawara, Takashi ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2013

In: AIDS Vol. 27, No. 2 ( 2013-01-14), p. 279-283

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In: AIDS, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 2 ( 2013-01-14), p. 279-283

Type of Medium: Online Resource

ISSN: 0269-9370

URL: Article

DOI: 10.1097/QAD.0b013e32835a5a7a

RVK:

XA 16838

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2013

detail.hit.zdb_id: 2012212-3

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