In:
Circulation: Cardiovascular Interventions, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 1 ( 2014-02), p. 35-42
Abstract:
Intravenous adenosine infusion produces coronary and systemic vasodilatation, generally leading to systemic hypotension. However, adenosine-induced hypotension during stable hyperemia is heterogeneous, and its relevance to coronary stenoses assessment with fractional flow reserve (FFR) remains largely unknown. Methods and Results— FFR, coronary flow reserve, and index of microcirculatory resistance were measured in 93 stenosed arteries (79 patients). Clinical and intracoronary measurements were analyzed among tertiles of the percentage degree of adenosine-induced hypotension, defined as follows: %ΔP a =–[100–(hyperemic aortic pressure×100/baseline aortic pressure)]. Overall, %ΔP a was –13.6±12.0%. Body mass index was associated with %ΔP a ( r =0.258; P =0.025) and obesity, an independent predictor of profound adenosine-induced hypotension (tertile 3 of %ΔP a ; odds ratio, 3.95 [95% confidence interval, 1.48–10.54]; P =0.006). %ΔP a was associated with index of microcirculatory resistance (ρ=0.311; P =0.002), coronary flow reserve ( r =–0.246; P =0.017), and marginally with FFR ( r =0.203; P =0.051). However, index of microcirculatory resistance (β=0.003; P 〈 0.001) and not %ΔP a (β=–0.001; P =0.564) was a predictor of FFR. Compared with tertiles 1 and 2 of %ΔP a (n=62 [66.6%]), stenoses assessed during profound adenosine-induced hypotension (n=31 [33.3%] ) had lower index of microcirculatory resistance (12.4 [8.6–22.7] versus 20 [15.8–35.5] ; P =0.001) and FFR values (0.77±0.13 versus 0.83±0.12; P =0.021), as well as a nonsignificant increase in coronary flow reserve (2.5±1.1 versus 2.2±0.87; P =0.170). Conclusions— The modification of systemic blood pressure during intravenous adenosine infusion is related to hyperemic microcirculatory resistance in the heart. Profound adenosine-induced hypotension is associated with obesity, lower coronary microcirculatory resistance, and lower FFR values.
Type of Medium:
Online Resource
ISSN:
1941-7640
,
1941-7632
DOI:
10.1161/CIRCINTERVENTIONS.113.000659
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2014
detail.hit.zdb_id:
2450801-9
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