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Effectiveness and Safety of Drug-Eluting Stents in Ontario

Tu, Jack V. ; Bowen, James ; Chiu, Maria ; [et al.]

Massachusetts Medical Society ; 2007

In: New England Journal of Medicine Vol. 357, No. 14 ( 2007-10-04), p. 1393-1402

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In: New England Journal of Medicine, Massachusetts Medical Society, Vol. 357, No. 14 ( 2007-10-04), p. 1393-1402

Type of Medium: Online Resource

ISSN: 0028-4793 , 1533-4406

URL: Article

DOI: 10.1056/NEJMoa071076

RVK:

XA 10000

Language: English

Publisher: Massachusetts Medical Society

Publication Date: 2007

detail.hit.zdb_id: 1468837-2

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Economic Evaluation of Early Psychosis Interventions From A Canadian Perspective

Tarride, Jean-Eric ; Blackhouse, Gord ; Abdel-Baki, Amal ; [et al.]

SAGE Publications ; 2022

In: The Canadian Journal of Psychiatry Vol. 67, No. 10 ( 2022-10), p. 768-777

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In: The Canadian Journal of Psychiatry, SAGE Publications, Vol. 67, No. 10 ( 2022-10), p. 768-777

Abstract: Compared to treatment as usual (TAU), early psychosis intervention programs (EPI) have been shown to reduce mortality, hospitalizations and days of assisted living while improving employment status. Aims The study aim was to conduct a cost-benefit analysis (CBA) and a cost-effectiveness analysis (CEA) to compare EPI and TAU in Canada. Methods A decision-analytic model was used to estimate the 5-year costs and benefits of treating patients with a first episode of psychosis with EPI or TAU. EPI benefits were derived from randomized controlled trials (RCTs) and Canadian administrative data. The cost of EPI was based on a published survey of 52 EPI centers in Canada while hospitalizations, employment and days of assisted living were valued using Canadian unit costs. The outcomes of the CBA and CEA were expressed in terms of net benefit (NB) and incremental cost per life year gained (LYG), respectively. Scenario analyses were conducted to examine the impact of key assumptions. Costs are reported in 2019 Canadian dollars. Results Base case results indicated that EPI had a NB of $85,441 (95% CI: $41,140; $126,386) compared to TAU while the incremental cost per LYG was $26,366 (95% CI: EPI dominates TAU (less costs, more life years); $102,269). In all sensitivity analyses the NB of EPI remained positive and the incremental cost per LYG was less than $50,000. Conclusions In addition to EPI demonstrated clinical benefits, our results suggest that large-scale implementation of EPI in Canada would be desirable from an economic point of view .

Type of Medium: Online Resource

ISSN: 0706-7437 , 1497-0015

URL: Article

DOI: 10.1177/07067437221087044

Language: English

Publisher: SAGE Publications

Publication Date: 2022

detail.hit.zdb_id: 2035338-8

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Opioid reduction and enhanced recovery in orthopaedic surgery (OREOS): a protocol for a feasibility randomised controlled trial in patients undergoing total knee arthroplasty

Madden, Kim ; Pallapothu, Sushmitha ; Young Shing, Darren ; [et al.]

Springer Science and Business Media LLC ; 2024

In: Pilot and Feasibility Studies Vol. 10, No. 1 ( 2024-02-15)

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In: Pilot and Feasibility Studies, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2024-02-15)

Abstract: Knee arthritis is a leading cause of limited function and long-term disability in older adults. Despite a technically successful total knee arthroplasty (TKA), around 20% of patients continue to have persisting pain with reduced function, and low quality of life. Many of them continue using opioids for pain control, which puts them at risk for potential long-term adverse effects such as dependence, overdose and risk of falls. Although persisting pain and opioid use after TKA have been recognised to be important issues, individual strategies to decrease their burden have limitations and multi-component interventions, despite their potential, have not been well studied. In this study, we propose a multi-component pathway including personalized pain management, facilitated by a pain management coordinator. The objectives of this pilot trial are to evaluate feasibility (recruitment, retention, and adherence), along with opioid-free pain control at 8 weeks after TKA. Methods This is a protocol for a multicentre pilot randomised controlled trial using a 2-arm parallel group design. Adult participants undergoing unilateral total knee arthroplasty will be considered for inclusion and randomised to control and intervention groups. Participants in the intervention group will receive support from a pain management coordinator who will facilitate a multicomponent pain management pathway including (1) preoperative education on pain and opioid use, (2) preoperative risk identification and mitigation, (3) personalized post-discharge analgesic prescriptions and (4) continued support for pain control and recovery up to 8 weeks post-op. Participants in the control group will undergo usual care. The primary outcomes of this pilot trial are to assess the feasibility of participant recruitment, retention, and adherence to the interventions, and key secondary outcomes are persisting pain and opioid use. Discussion The results of this trial will determine the feasibility of conducting a definitive trial for the implementation of a multicomponent pain pathway to improve pain control and reduce harms using a coordinated approach, while keeping an emphasis on patient centred care and shared decision making. Trial registration Prospectively registered in Clinicaltrials.gov (NCT04968132).

Type of Medium: Online Resource

ISSN: 2055-5784

URL: Article

DOI: 10.1186/s40814-024-01457-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2024

detail.hit.zdb_id: 2809935-7

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Ontario Multidetector Computed Tomographic Coronary Angiography Study : Field Evaluation of Diagnostic Accuracy

Chow, Benjamin J. W. ; Freeman, Michael R. ; Bowen, James M. ; [et al.]

American Medical Association (AMA) ; 2011

In: Archives of Internal Medicine Vol. 171, No. 11 ( 2011-06-13)

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In: Archives of Internal Medicine, American Medical Association (AMA), Vol. 171, No. 11 ( 2011-06-13)

Type of Medium: Online Resource

ISSN: 0003-9926

URL: Article

DOI: 10.1001/archinternmed.2011.74

RVK:

XA 29200

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2011

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Infectious diseases, comorbidities and outcomes in hospitalized people who inject drugs (PWID) infections in persons who inject drugs

Lim, Jacqueline ; Pavalagantharajah, Sureka ; Verschoor, Chris P ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 4 ( 2022-4-20), p. e0266663-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 4 ( 2022-4-20), p. e0266663-

Abstract: Injection drug use poses a public health challenge. Clinical experience indicates that people who inject drugs (PWID) are hospitalized frequently for infectious diseases, but little is known about outcomes when admitted. Charts were identified from local hospitals between 2013–2018 using consultation lists and hospital record searches. Included individuals injected drugs in the past six months and presented with infection. Charts were accessed using the hospital information system, undergoing primary and secondary reviews using Research Electronic Data Capture (REDCap). The Wilcoxon rank-sum test was used for comparisons between outcome categories. Categorical data were summarized as count and frequency, and compared using Fisher’s exact test. Of 240 individuals, 33% were admitted to the intensive care unit, 36% underwent surgery, 12% left against medical advice (AMA), and 9% died. Infectious diagnoses included bacteremia (31%), abscess (29%), endocarditis (29%), cellulitis (20%), sepsis (10%), osteomyelitis (9%), septic arthritis (8%), pneumonia (7%), discitis (2%), meningitis/encephalitis (2%), or other (7%). Sixty-six percent had stable housing and 60% had a family physician. Fifty-four percent of patient-initiated discharges were seen in the emergency department within 30 days and 29% were readmitted. PWID are at risk for infections. Understanding their healthcare trajectory is essential to improve their care.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0266663

DOI: 10.1371/journal.pone.0266663.t001

DOI: 10.1371/journal.pone.0266663.t002

DOI: 10.1371/journal.pone.0266663.t003

DOI: 10.1371/journal.pone.0266663.t004

DOI: 10.1371/journal.pone.0266663.s001

DOI: 10.1371/journal.pone.0266663.s002

DOI: 10.1371/journal.pone.0266663.r001

DOI: 10.1371/journal.pone.0266663.r002

DOI: 10.1371/journal.pone.0266663.r003

DOI: 10.1371/journal.pone.0266663.r004

DOI: 10.1371/journal.pone.0266663.r005

DOI: 10.1371/journal.pone.0266663.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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Economic evaluation of drug-eluting stents compared to bare metal stents using a large prospective study in Ontario

Goeree, Ron ; Bowen, James M. ; Blackhouse, Gord ; [et al.]

Cambridge University Press (CUP) ; 2009

In: International Journal of Technology Assessment in Health Care Vol. 25, No. 02 ( 2009-4), p. 196-207

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In: International Journal of Technology Assessment in Health Care, Cambridge University Press (CUP), Vol. 25, No. 02 ( 2009-4), p. 196-207

Abstract: Objectives: To determine the cost-effectiveness (CE) and cost-utility (CU) of drug-eluting stents (DES) compared to bare metal stents (BMS) in Ontario using a large prospective “real-world” cohort study and determine the extent to which results vary by patient risk subgroups. Methods: A field evaluation was conducted based on all stent procedures in the province of Ontario between December 1, 2003, and March 31, 2005, with a minimum subject follow-up of 1 year. Effectiveness data from the study using a propensity-score matched cohort were combined with resource utilization and cost data and quality of life (QOL) data from the published literature in a decision analytic modeling framework to determine 2-year cost-effectiveness (cost per revascularization avoided) and cost-utility (cost per quality-adjusted life-year ([QALY] gained). Stochastic model parameter uncertainty was expressed using probability distributions and analyzed using a probabilistic model. Modeling assumptions were assessed using traditional deterministic sensitivity analysis. Results: Significant differences in revascularization rates were found for patients with two or more high risk factors. Despite these differences, the CE and CU of DES remained high (e.g., $419,000 per QALY gained in the most favorable patient risk subgroup). In sensitivity analysis, the difference in cost between DES and BMS had an impact on the CE and CU results. For example, at a price differential of $500, the CU of DES was $20,000/QALY for one patient subgroup and DES was dominant (i.e., less costly and more effective) in another. Conclusions: At current prices, the CE/CU of DES compared with BMS is high even in patient high risk subgroups. As the relative price of DES decrease, the value for money attractiveness of DES increases, especially for selected high risk patients.

Type of Medium: Online Resource

ISSN: 0266-4623 , 1471-6348

URL: Article

DOI: 10.1017/S0266462309090254

Language: English

Publisher: Cambridge University Press (CUP)

Publication Date: 2009

detail.hit.zdb_id: 2020486-3

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Persistence and adherence to cholesterol lowering agents: Evidence from Régie de l'Assurance Maladie du Québec data

Lachaine, Jean ; Rinfret, Stephane ; Merikle, Elizabeth P. ; [et al.]

Elsevier BV ; 2006

In: American Heart Journal Vol. 152, No. 1 ( 2006-07), p. 164-169

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In: American Heart Journal, Elsevier BV, Vol. 152, No. 1 ( 2006-07), p. 164-169

Type of Medium: Online Resource

ISSN: 0002-8703

URL: Article

DOI: 10.1016/j.ahj.2005.09.010

RVK:

XA 18100

Language: English

Publisher: Elsevier BV

Publication Date: 2006

detail.hit.zdb_id: 2003210-9

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A Model for Assessing the Cost-Effectiveness of Atorvastatin and Simvastatin in Achieving Canadian Low-Density Lipoprotein Cholesterol Targets

Lachaine, Jean ; Merikle, Elizabeth ; Tarride, Jean-Eric ; [et al.]

Elsevier BV ; 2007

In: Clinical Therapeutics Vol. 29, No. 3 ( 2007-3), p. 519-528

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In: Clinical Therapeutics, Elsevier BV, Vol. 29, No. 3 ( 2007-3), p. 519-528

Type of Medium: Online Resource

ISSN: 0149-2918

URL: Article

DOI: 10.1016/S0149-2918(07)80089-0

Language: English

Publisher: Elsevier BV

Publication Date: 2007

detail.hit.zdb_id: 2025417-9

SSG: 15,3

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Prevalence and incidence of Paget's disease of bone: Temporal trend over 20 years in the province of Quebec, Canada

Michou, Laetitia ; Gamache, Philippe ; Guertin, Jason R. ; [et al.]

Elsevier BV ; 2023

In: Bone Vol. 176 ( 2023-11), p. 116895-

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In: Bone, Elsevier BV, Vol. 176 ( 2023-11), p. 116895-

Type of Medium: Online Resource

ISSN: 8756-3282

URL: Article

DOI: 10.1016/j.bone.2023.116895

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 1496324-3

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MP11-14 COST EFFECTIVENESS OF TARGETED ANTIMICROBIAL THERAPY IN TRANSRECTAL ULTRASOUND-GUIDED PROSTATE BIOPSY

Yassein, Alaya ; Tarride, Jean-Eric ; Davies, Timothy

Ovid Technologies (Wolters Kluwer Health) ; 2017

In: Journal of Urology Vol. 197, No. 4S ( 2017-04)

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In: Journal of Urology, Ovid Technologies (Wolters Kluwer Health), Vol. 197, No. 4S ( 2017-04)

Type of Medium: Online Resource

ISSN: 0022-5347 , 1527-3792

URL: Article

DOI: 10.1016/j.juro.2017.02.415

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2017

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