In:
Genetics, Oxford University Press (OUP), Vol. 81, No. 3 ( 1975-11-05), p. 515-523
Abstract:
The 5S RNA genes of Drosophila melanogaster in either an isogenic wild-type or a multiply inverted (SM1) chromosome 2 increase their multiplicity when opposite a deficiency for the 5S gene site. This is analogous to the compensation phenomenon previously described for the 18S and 28S ribosomal RNA genes of the X chromosome nucleolus organizer region. Molecular hybridization of 5S RNA to DNA containing various doses of the 56F1-9 region of chromosome 2 demonstrates that most, if not all, of the 5S genes reside in or near this region. Also, a deficiency missing approximately one-half of the wild-type number of 5S genes was isolated and genetically localized. This mutant has a phenotype like that of bobbed, a mutant known to be partially deficient in 18S and 28S ribosomal RNA genes. Finally, we report the existence of a chromosomal rearrangement which splits the second chromosome into two segments, each containing 5S DNA.
Type of Medium:
Online Resource
ISSN:
1943-2631
DOI:
10.1093/genetics/81.3.515
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1975
detail.hit.zdb_id:
1477228-0
SSG:
12
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