In:
The Journal of Dermatology, Wiley, Vol. 46, No. 5 ( 2019-05), p. 444-448
Abstract:
Cyclin‐dependent kinase 4 and 6 ( CDK 4/6) plays an important role in cell cycle progression, and the CDK 4/6–cyclin D1 complex controls the cell cycle transition from G 1 phase to S phase. CDK 4 is enhanced in several types of cancers and CDK 4/6 inhibitors attenuate the proliferation of several types of cancer in vitro / in vivo . The purpose of our study was to investigate the expression pattern of CDK 4 and evaluate its clinical importance in extramammary Paget's disease (EMPD). Almost all EMPD tissues were positive for CDK 4, and metastatic lesions had a similar immunostaining intensity to primary lesions. In addition, CDK 4 protein levels were positively correlated with those of cyclin D1 protein. Taken together, CDK 4 may assume a crucial role in EMPD progression.
Type of Medium:
Online Resource
ISSN:
0385-2407
,
1346-8138
DOI:
10.1111/jde.2019.46.issue-5
DOI:
10.1111/1346-8138.14858
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2222121-9
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