In:
Breast Care, S. Karger AG, Vol. 17, No. 2 ( 2022), p. 121-129
Abstract:
〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 Classical type of lobular neoplasia (LN) encompassing both atypical lobular hyperplasia and classical lobular carcinoma in situ of the breast is a lesion with uncertain malignant potential and has been the topic of several studies with conflicting outcome results. The aim of our study was to clarify outcome-relevant factors and treatment options of classical LN. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We performed a pathological re-evaluation of the preoperative biopsy specimens and a retrospective clinical and radiological data analysis of 160 patients with LN from the Breast Center Zurich. Open surgery was performed in 65 patients, vacuum-assisted biopsy (VAB) in 79 patients, and surveillance after breast core needle biopsy (CNB) in 16 patients. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The upgrade rate into ductal carcinoma in situ/invasive cancer was the highest in case of imaging/histology discordance (40%). If the number of foci in the biopsy specimen was ≥3, the upgrade rate in the consecutive surgical specimens was increased ( 〈 i 〉 p 〈 /i 〉 = 0.01). The association of classical LN with histological microcalcification correlated with shortened disease-free survival ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.01), whereas other factors showed no impact on follow-up. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Surveillance or subsequent VAB after CNB of LN is sufficient in most cases. Careful consideration of individual radiological and histological factors is required to identify patients with a high risk of upgrade into malignancy. In those cases, surgical excision is indicated.
Type of Medium:
Online Resource
ISSN:
1661-3791
,
1661-3805
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
2205941-6
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