In:
Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 21, No. 6 ( 2001-06), p. 664-670
Abstract:
The authors investigated the influence of variations in global cerebral blood flow (gCBF) on regional flow changes during visual stimulation. Global flow was varied using different end-expiratory CO 2 values (Petco 2 ) between 20 and 70 mm Hg. Visual stimulation was performed with a red LED-array flashing at 8 Hz. Blood flow was measured with O-15-butanol, continuous arterial blood sampling, and positron emission tomography (PET). Global flow changes surpassed the published values of O-15-H 2 O studies, better fitting the results of the inert gas technique (gCBF at 20, 40, and 70 mm Hg Petco 2 ± SD was 31 ± 4, 48 ± 13, and 160 ± 50 mL 100 g −1 min −1 , respectively). The relation between Petco 2 and CBF in the current study was best described by an exponential rather than a linear function. At low Petco 2 , the activation-induced flow changes are moderately damped, whereas at high Petco 2 , they are nearly lost (ΔCBF (±SD): 52% ± 25%, 68% ± 22%, 16% ± 25% at Petco 2 = 20, 40, 70 mm Hg, respectively).
Type of Medium:
Online Resource
ISSN:
0271-678X
,
1559-7016
DOI:
10.1097/00004647-200106000-00004
Language:
English
Publisher:
SAGE Publications
Publication Date:
2001
detail.hit.zdb_id:
2039456-1
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