In:
Zeitschrift für Naturforschung C, Walter de Gruyter GmbH, Vol. 68, No. 11-12 ( 2013-12-1), p. 453-460
Abstract:
A new series of 5-(p-substituted benzamido/phenylacetamido)-2-(p-tert-butylphenyl)benzoxazole derivatives were synthesized and evaluated for their antibacterial, antifungal, and antimycobacterial activities against antibiotic-resistant and -sensitive Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and Mycobacterium tuberculosis as well as against Candida albicans and Candida krusei. The compounds possessed broad-spectrum activity against all of the tested Gram-positive and Gram-negative bacteria and yeasts, their minimum inhibitory concentrations (MICs) ranging between 16 - 128 μg/ml. One compound exhibited significant antibacterial activity (16 μg/ml) against an antibioticresistant Enterococcus faecalis isolate, having twice the potency of the compared standard drugs vancomycin and gentamycin sulfate. The compounds also showed moderate antitubercular activity with MIC values between 8 - 128 μg/ml against Mycobacterium tuberculosis and its clinical isolate.
Type of Medium:
Online Resource
ISSN:
1865-7125
,
0939-5075
DOI:
10.1515/znc-2013-11-1204
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2013
detail.hit.zdb_id:
2078107-6
SSG:
12
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