In:
Hormone Research in Paediatrics, S. Karger AG, Vol. 50, No. Suppl. 2 ( 1998), p. 37-45
Abstract:
It is well known that maternal fibrinogen (Fg) and factor X III are essential for maintaining early pregnancy. We studied their role by analysis of clinical reports and immunohistochemical investigation. 〈 b 〉 Methods: 〈 /b 〉 (1) We analyzed the pregnancy cases of congenital afibrinogenemia and congenital factor X III deficiency. (2) Immunohistochemical staining of Fg, subunit A of factor X III (X III 〈 sub 〉 A 〈 /sub 〉 ) and fibronectin (Fn) were performed in the human implantation site, placenta, and endometrial cells cultured in serum-free medium. 〈 b 〉 Results: 〈 /b 〉 (1) Afibrinogenemia needed to be administrated Fg from 4 weeks’ gestation (4 wG), and factor X III deficiency needed factor X III concentrate from 5 wG, in order to prevent abortion. (2) 〈 i 〉 Implantation tissues: 〈 /i 〉 Fg, cellular X III 〈 sub 〉 A 〈 /sub 〉 and Fn were present at the decidual stroma around invasive cytotrophoblasts at 5 wG. X III 〈 sub 〉 A 〈 /sub 〉 -positive cells coincided with LN-5-positive macrophages. 〈 i 〉 Placenta: 〈 /i 〉 Fg, cellular X III 〈 sub 〉 A 〈 /sub 〉 and Fn were present in the decidual layer. 〈 i 〉 Endometrial culture cells: 〈 /i 〉 Fn was secreted by spindle-like shaped cells. X III 〈 sub 〉 A 〈 /sub 〉 was secreted by round-shaped cells. 〈 b 〉 Conclusion: 〈 /b 〉 Maternal Fg and factor X III are essential just after 4∼5 wG, and in that period they and Fn are present abundantly in decidual stroma around invasive cytotrophoblasts. It is concluded that when cytotrophoblasts invade endometrium maternal Fg, factor X III and Fn are concerned with cytotrophoblasts’ anchoring as adhesive proteins.
Type of Medium:
Online Resource
ISSN:
1663-2818
,
1663-2826
Language:
English
Publisher:
S. Karger AG
Publication Date:
1998
detail.hit.zdb_id:
2540224-9
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