In:
International Journal of Cancer, Wiley, Vol. 143, No. 7 ( 2018-10), p. 1706-1719
Abstract:
What's new? Evidence suggests that familial non‐medullary thyroid carcinoma (FNMTC) is highly heterogeneous, complicating the identification of underlying mutations in family pedigrees. Here, investigation of chromosome 19p13.2, which contains a known thyroid cancer‐predisposing locus, led to the identification of a novel mutation in the gene MYO1F . Relative to wild‐type controls, thyroid cell models carrying mutant MYO1F exhibited a significant increase in colony formation and greater potential for invasion and anchorage‐independent growth. Mutated cells further showed an altered mitochondrial phenotype, similar to the one observed in human thyroid tumors. The findings suggest that MYO1F has a role in thyroid cancer predisposition.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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