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1

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Changes in Patterns of Hospitalized Children With Varicella and of Associated Varicella Genotypes After Introduction of Varicella Vaccine in Australia

Marshall, Helen S. ; McIntyre, Peter ; Richmond, Peter ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2013

In: Pediatric Infectious Disease Journal Vol. 32, No. 5 ( 2013-05), p. 530-537

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In: Pediatric Infectious Disease Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 32, No. 5 ( 2013-05), p. 530-537

Type of Medium: Online Resource

ISSN: 0891-3668

URL: Article

DOI: 10.1097/INF.0b013e31827e92b7

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2013

detail.hit.zdb_id: 2020216-7

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2

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Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

Vonlaufen, Alain ; Joshi, Swapna ; Qu, Changfa ; [et al.]

American Association for Cancer Research (AACR) ; 2008

In: Cancer Research Vol. 68, No. 7 ( 2008-04-01), p. 2085-2093

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In: Cancer Research, American Association for Cancer Research (AACR), Vol. 68, No. 7 ( 2008-04-01), p. 2085-2093

Abstract: Pancreatic stellate cells (PSC) produce the stromal reaction in pancreatic cancer, but their role in cancer progression is not fully elucidated. We examined the influence of PSCs on pancreatic cancer growth using (a) an orthotopic model of pancreatic cancer and (b) cultured human PSCs (hPSC) and human pancreatic cancer cell lines MiaPaCa-2 and Panc-1. Athymic mice received an intrapancreatic injection of saline, hPSCs, MiaPaCa-2 cells, or hPSCs + MiaPaCa-2. After 7 weeks, tumor size, metastases, and tumor histology were assessed. In vitro studies assessed the effect of cancer cell secretions on PSC migration and the effect of hPSC secretions on cancer cell proliferation, apoptosis, and migration. Possible mediators of the effects of hPSC secretions on cancer cell proliferation were examined using neutralizing antibodies. Compared with mice receiving MiaPaCa-2 cells alone, mice injected with hPSCs + MiaPaCa-2 exhibited (a) increased tumor size and regional and distant metastasis, (b) fibrotic bands (desmoplasia) containing activated PSCs within tumors, and (c) increased tumor cell numbers. In vitro studies showed that, in the presence of pancreatic cancer cells, PSC migration was significantly increased. Furthermore, hPSC secretions induced the proliferation and migration, but inhibited the apoptosis, of MiaPaCa-2 and Panc-1 cells. The proliferative effect of hPSC secretions on pancreatic cancer cells was inhibited in the presence of neutralizing antibody to platelet-derived growth factor. Our studies indicate a significant interaction between pancreatic cancer cells and stromal cells (PSCs) and imply that pancreatic cancer cells recruit stromal cells to establish an environment that promotes cancer progression. [Cancer Res 2008;68(7):2085–93]

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/0008-5472.CAN-07-2477

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2008

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

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3

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Prevalence of varicella-zoster virus genotypes in Australia characterized by high-resolution melt analysis and ORF22 gene analyses

Toi, Cheryl S. ; Dwyer, Dominic E.

Microbiology Society ; 2010

In: Journal of Medical Microbiology Vol. 59, No. 8 ( 2010-08-01), p. 935-940

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In: Journal of Medical Microbiology, Microbiology Society, Vol. 59, No. 8 ( 2010-08-01), p. 935-940

Abstract: DNA sequence variation analysis has divided varicella-zoster virus (VZV; Human herpesvirus 3 ) into distinct geographical clades: European, Asian, African and Japanese. These genotypes are becoming increasingly prevalent within regions atypical to their original source and there has been the suggestion of recombination between genotypes. Seventy-eight clinical isolates from hospitalized patients with varicella were collected in New South Wales, the Northern Territory, Western Australia and Victoria from 2006 to 2009. The wild-type strains and the vaccine strain (vOka) were differentiated by single nucleotide polymorphism detection using high-resolution melt analysis of five target genes (ORF1, -21, -37, -60 and -62), and by DNA sequence analysis of a 484 bp region of ORF22. Phylogenetic analysis showed that 46 % (36/78) of the clinical isolates were European clade 1 (C/E1) strains, 21 % (16/78) were European clade 3 (B/E2) strains, 12 % (9/78) were Asian/African clade 5 (A/M1) strains, 10 % (8/78) were clade 4 (J2/M2), 6 % (5/78) were clade 2 (J/J) and 5 % (4/78) belonged to the novel clade VI. No significant association was shown between VZV genotype and region, age or gender. Although European strains were most common, the results suggest an increase in African/Asian, Japanese and clade VI genotypes circulating in Australia.

Type of Medium: Online Resource

ISSN: 0022-2615 , 1473-5644

URL: Article

DOI: 10.1099/jmm.0.019547-0

RVK:

XA 55020

Language: English

Publisher: Microbiology Society

Publication Date: 2010

detail.hit.zdb_id: 2083944-3

SSG: 12

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4

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Achieving Mental Health Equity

Harris, Toi Blakley ; Udoetuk, Sade C. ; Webb, Sala ; [et al.]

Elsevier BV ; 2020

In: Psychiatric Clinics of North America Vol. 43, No. 3 ( 2020-09), p. 471-485

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In: Psychiatric Clinics of North America, Elsevier BV, Vol. 43, No. 3 ( 2020-09), p. 471-485

Type of Medium: Online Resource

ISSN: 0193-953X

URL: Article

DOI: 10.1016/j.psc.2020.06.001

Language: English

Publisher: Elsevier BV

Publication Date: 2020

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5

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Identification of putative kdr mutations in the tropical bed bug, Cimex hemipterus (Hemiptera: Cimicidae)

Dang, Kai ; Toi, Cheryl S ; Lilly, David G ; [et al.]

Wiley ; 2015

In: Pest Management Science Vol. 71, No. 7 ( 2015-07), p. 1015-1020

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In: Pest Management Science, Wiley, Vol. 71, No. 7 ( 2015-07), p. 1015-1020

Abstract: Bed bugs [both Cimex hemipterus (F.) and Cimex lectularius L.] are highly resistant to pyrethroids worldwide. An important resistance mechanism known as ‘knockdown resistance’ ( kdr ) is caused by genetic point mutations on the voltage‐gated sodium channel ( VGSC ) gene. Previous studies have identified two point mutations ( V419L and L925I ) on the VGSC gene in C. lectularius that are responsible for kdr ‐type resistance. However, the kdr mutations in C. hemipterus have not been investigated. RESULTS Four novel mutations, L899V ( leucine to valine ), M918I ( methionine to isoleucine ), D953G ( aspartic acid to glycine ) and L1014F ( leucine to phenylalanine ), were identified in the domain II region of the C. hemipterus VGSC gene. This region has been widely investigated for the study of kdr ‐type resistance to pyrethroids in other insect pests. The V419L and L925I kdr mutations as previously identified in C. lectularius were not detected in C. hemipterus . CONCLUSION M918I and L1014F are considered to be probable kdr mutations and may play essential roles in kdr ‐type resistance to pyrethroids in C. hemipterus . Further studies are under way in the authors' laboratory to determine the non‐ kdr ‐type resistance mechanisms in C. hemipterus . © 2014 Society of Chemical Industry

Type of Medium: Online Resource

ISSN: 1526-498X , 1526-4998

URL: Issue

URL: Article

DOI: 10.1002/ps.2015.71.issue-7

DOI: 10.1002/ps.3880

Language: English

Publisher: Wiley

Publication Date: 2015

detail.hit.zdb_id: 2003455-6

SSG: 12

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6

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Detection of knockdown resistance mutations in the common bed bug, Cimex lectularius (Hemiptera: Cimicidae), in Australia

Dang, Kai ; Toi, Cheryl S ; Lilly, David G ; [et al.]

Wiley ; 2015

In: Pest Management Science Vol. 71, No. 7 ( 2015-07), p. 914-922

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In: Pest Management Science, Wiley, Vol. 71, No. 7 ( 2015-07), p. 914-922

Abstract: Pyrethroid resistance in the common bed bug, Cimex lectularius L., has been reported worldwide. An important resistance mechanism is via knockdown resistance ( kdr ) mutations, notably V419L and L925I . Information regarding this kdr ‐type resistance mechanism is unknown in Australia. This study aims to examine the status of kdr mutations in Australian C. lectularius strains. RESULTS Several modern field‐collected strains and museum‐preserved reference collections of Australian C. lectularius were examined. Of the field strains (2007–2013), 96% had the known kdr mutations ( L925I or both V419L / L925I ). The ‘Adelaide’ strain (2013) and samples from the preserved reference collections (1994–2002) revealed no known kdr mutations. A novel mutation I936F was apparent in the insecticide‐resistant ‘Adelaide’ strain, one strain from Perth (with L925I ) and the majority of the reference collection specimens. The laboratory insecticide‐resistant ‘Sydney’ strain showed a mixture of no kdr mutations (20%) and L925I (80%). CONCLUSION The novel mutation I936F may be a kdr mutation but appeared to contribute less resistance to the pyrethroids than the V419L and L925I mutations. The detection of high frequencies of kdr mutations indicates that kdr ‐type resistance is widespread across Australia. Hence, there should be a reduced reliance on pyrethroid insecticides and an integrated management approach for the control of C. lectularius infestations. © 2014 Society of Chemical Industry

Type of Medium: Online Resource

ISSN: 1526-498X , 1526-4998

URL: Issue

URL: Article

DOI: 10.1002/ps.2015.71.issue-7

DOI: 10.1002/ps.3861

Language: English

Publisher: Wiley

Publication Date: 2015

detail.hit.zdb_id: 2003455-6

SSG: 12

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7

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Prolonged varicella viraemia and streptococcal toxic shock syndrome following varicella vaccination of a health care worker

Italiano, Claire M ; Toi, Cheryl S ; Chan, Simon P ; [et al.]

Wiley ; 2009

In: Medical Journal of Australia Vol. 190, No. 8 ( 2009-04), p. 451-453

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In: Medical Journal of Australia, Wiley, Vol. 190, No. 8 ( 2009-04), p. 451-453

Type of Medium: Online Resource

ISSN: 0025-729X , 1326-5377

URL: Issue

URL: Article

DOI: 10.5694/mja2.2009.190.issue-8

DOI: 10.5694/j.1326-5377.2009.tb02498.x

Language: English

Publisher: Wiley

Publication Date: 2009

detail.hit.zdb_id: 2035730-8

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8

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Diagnosis of Barmah Forest Virus Infection by a Nested Real-Time SYBR Green RT-PCR Assay

Hueston, Linda ; Toi, Cheryl S. ; Jeoffreys, Neisha ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 7 ( 2013-7-23), p. e65197-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 7 ( 2013-7-23), p. e65197-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0065197

DOI: 10.1371/journal.pone.0065197.t001

DOI: 10.1371/journal.pone.0065197.t002

DOI: 10.1371/journal.pone.0065197.t003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2267670-3

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9

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Differentiation between vaccine and wild-type varicella-zoster virus genotypes by high-resolution melt analysis of single nucleotide polymorphisms

Toi, Cheryl S. ; Dwyer, Dominic E.

Elsevier BV ; 2008

In: Journal of Clinical Virology Vol. 43, No. 1 ( 2008-9), p. 18-24

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In: Journal of Clinical Virology, Elsevier BV, Vol. 43, No. 1 ( 2008-9), p. 18-24

Type of Medium: Online Resource

ISSN: 1386-6532

URL: Article

DOI: 10.1016/j.jcv.2008.03.027

Language: English

Publisher: Elsevier BV

Publication Date: 2008

detail.hit.zdb_id: 1499932-8

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Varicella zoster virus quantitation in blood from symptomatic and asymptomatic individuals : VZV Quantitation in Blood

Toi, Cheryl S. ; Lay, Meav-Lang J. ; Lucas, Robyn ; [et al.]

Wiley ; 2013

In: Journal of Medical Virology Vol. 85, No. 8 ( 2013-08), p. 1491-1497

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In: Journal of Medical Virology, Wiley, Vol. 85, No. 8 ( 2013-08), p. 1491-1497

Type of Medium: Online Resource

ISSN: 0146-6615

URL: Article

DOI: 10.1002/jmv.23605

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2013

detail.hit.zdb_id: 752392-0

detail.hit.zdb_id: 1475090-9

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