In:
Lipids, Wiley, Vol. 18, No. 11 ( 1983-11), p. 848-850
Abstract:
1‐0‐Hexadecyl‐2‐0‐acetyl‐ sn ‐glycero‐3‐phosphocholine (platelet‐activating factor) at 10 −10 ‐10 −9 M induced slow contraction of isolated guinea‐pig ilcal muscles and the contraction persisted for a long time. At a higher concentration of 10 −7 M, this phospholipid induced more rapid, but not greater, contraction. At higher concentrations (10 −6 ‐10 −5 M), this phospholipid induced a biphasic response: rapid contraction followed by relaxation. At high concentrations, this compound inhibited acetylcholine‐induced contractions. The stimulatory effect of this phospholipid was ca. 300 times that of 1‐palmitoyl‐2‐0‐acetyl‐ sn ‐glycero‐3‐phosphocholine, while its inhibitory potency on induced contraction was similar to those of 1‐palmitoyl‐2‐0‐acetyl‐ sn ‐glycero‐3‐phosphocholine and its lyso derivative. It was suggested that the differences in effects on contraction of different concentrations of 1‐0‐hexadecyl‐ and 1‐palmitoyl‐2‐0‐acetyl‐ sn ‐glycero‐3‐phosphocholine were due to the dual effects of these compounds on the ileum: a strong stimulatory effect and a moderate inhibitory effect on contraction.
Type of Medium:
Online Resource
ISSN:
0024-4201
,
1558-9307
Language:
English
Publisher:
Wiley
Publication Date:
1983
detail.hit.zdb_id:
2030265-4
SSG:
12
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