In:
Molecular Systems Biology, EMBO, Vol. 19, No. 9 ( 2023-09-12)
Abstract:
image Multi‐omics analysis allows for an in‐depth view of the molecular dynamics of a microbial ecosystem. The study evaluates if different omics data types show similar results or if each of them provides unique insights into the dynamics of a drug‐perturbed microbial ecosystem. The estimation of relative species abundance is highly consistent between omics methods that allow species resolution. For capturing functional changes, each omics data type shows slightly different results, showing the usefulness of studying a system on different molecular levels. The antipsychotic drug chlorpromazine selectively inhibits Bacteroidota representatives in a synthetic community of 32 gut microbiome species, leading to a decreased oligosaccharide uptake and induction of stress responses related to protein quality control. The synthetic community breaks down the antihelmintic drug niclosamide, likely protecting community members from the drug.
Type of Medium:
Online Resource
ISSN:
1744-4292
,
1744-4292
DOI:
10.15252/msb.202311525
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
2193510-5
SSG:
12
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