In:
European Neurology, S. Karger AG, Vol. 84, No. 3 ( 2021), p. 168-174
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 There is a lack of evidence about the usefulness of exercise or rest in myasthenia gravis (MG). This study is aimed to evaluate the efficacy and safety of exercise or rest in MG. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a single-center open-labeled randomized controlled trial, the patients with mild to moderate MG were randomized to 30-min walk or rest in addition to the standard treatment. The primary endpoint was 50% improvement in the MG Quality of Life (MG-QOL15), and secondary endpoints were change in the Myasthenic Muscle Score (MMS), MG Activities of Daily Living (MGADL), grip strength, dose of acetylcholine esterase inhibitor and prednisone, 6-min walk test (6MWT), decrement in trapezius on the low-rate repetitive nerve stimulation test, and adverse events. The outcomes were defined at 3 months, by & #x3e;50% improvement in these outcome parameters. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Forty patients with MG were randomized to the exercise or rest arm. The 2 arms were matched for demographic and clinical parameters. The patients in the exercise arm had significantly better QOL evidenced by MG-QOL15 ( 〈 i 〉 p = 〈 /i 〉 0.02). The secondary endpoints, distance covered in 6MWT ( 〈 i 〉 p = 〈 /i 〉 0.007), were also better in the exercise arm without any adverse event. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Regular exercise for 30 min in mild and moderate MG improves quality of life and walking distance compared to rest and is safe. 〈 b 〉 〈 i 〉 Clinical Trial Registration: 〈 /i 〉 〈 /b 〉 The clinical trial registration number is CTRI/2019/11/021869.
Type of Medium:
Online Resource
ISSN:
0014-3022
,
1421-9913
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
1482237-4
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