In:
Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam, Vietnamese Journal of Food Control, National Institute for Food Control, Vol. 5, No. 3 ( 2022-09-24), p. 462-473
Abstract:
Nowadays, there were many reports from Viet nam & amp; international laboratories have & nbsp;detected many kinds of undeclared synthesis drugs, even of banned-chemicals in health & nbsp;supplement products (HSP). We developed methods on LC-MS/MS to detect synthesis & nbsp;pharmaceutical drugs in following groups of HSP: strengthen sexual for man group: sildenafil, Tadalafil, Vardenafil; Anti- arthritis group: Dexamethasone, Prednisolon, & nbsp;Betamethasone, Piroxicam; Slimming group: Sibutramin, Orlistate, Phenophtalein, & nbsp;Furosemid. We carried out method validation of specificities & amp; limit of dectections of above & nbsp;drugs on mass spectrometer system of Triple Quad SCiex 55000, analysis 80 samples of & nbsp;each group HSP were collected from 4 provinces: Dong nai, Binh Duong, Ba Ria- Vung & nbsp;Tau, Binh Phuoc in 2020. We validated fragment transition & amp; LOD of each drugs: Sidenafil & nbsp;(mz 475.2 & rarr; 100.2/ 283.2), LOD: 0.015ppm;Tadanafil (mz 390.1 & rarr; 268.1/262.1) LOD: & nbsp;0.015 ppm; Vadernafil (mz 483.9 & rarr; 312.3/299.2), LOD: 0.07ppm; Prednisolon (mz 361 & rarr; & nbsp;147/343.3), LOD: 0.075ppm; Dexamethason (mz 393.2 & rarr; 373.1/293.1); LOD: 0.02 ppm; & nbsp;Betamethason (mz 393.1 & rarr; 147.1/355.2)LOD: 0.075 ppm; Piroxicam (mz 330 & rarr; & nbsp;266.2/146.1); LOD: 0.015 ppm; Sibutramin (mz 280.9 & rarr; 139/125.2), LOD: 0.75 ppm; Orlistate (mz 496. & rarr; 179,2/ 114.1), LOD: 1 ppm; Phenophtalein (mz 319,2 & rarr; 141.1/283.2), & nbsp;LOD: 0.01 ppm; Furosemid (mz 329.2 & rarr; 285/204), LOD: 0.01 ppm. Screenning results: & nbsp;Sidenafil nondetected/80 samples; Tadalafil positive 10/80 samples, Vadernafil & nbsp;nondetected/80 samples in man sexual enhancement HSP; Prednisonlon nondetected /80 & nbsp;samples, Dexamethason nondetected /80 samples; Betamethason positive 1/80 samples, & nbsp;Piroxicam nondetected /80 samples in anti-arthritis HSP. Sibutramin & amp; Phenolphtalein & nbsp;positive 7/80 samples, Orlistate nondetected/80 samples, Furosemid nondetected/80 samples in slimming HSP.
Type of Medium:
Online Resource
ISSN:
2615-9252
DOI:
10.47866/2615-9252/vjfc.3965
Language:
Unknown
Publisher:
Vietnamese Journal of Food Control, National Institute for Food Control
Publication Date:
2022
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