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  • 1
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    Ocena niedoborów witaminy D w grupie pacjentów z ciężką przewlekłą obturacyjną chorobą płuc w stadium przewlekłej niewydolności oddechowej
    MDPI AG ; 2018
    In:  Advances in Respiratory Medicine Vol. 86, No. 102 ( 2018-08-18), p. 2-2
    Details
    In: Advances in Respiratory Medicine, MDPI AG, Vol. 86, No. 102 ( 2018-08-18), p. 2-2
    Abstract: Wstęp: Celem pracy była ocena stężenia witaminy D w surowicy chorych z niewydolnością oddechową w przebiegu przewlekłej obturacyjnej choroby płuc POChP w porównaniu z grupą kontrolną złożoną ze zdrowych osób. Dodatkowym celem badania była analiza korelacji stężenia witaminy D w surowicy z wybranymi parametrami klinicznymi, gazometrycznymi i spirometrycznymi. Materiał i metody: Badaniem objęto 61 osób z POChP w stadium przewlekłej niewydolności oddechowej (45 mężczyzn oraz 16 kobiet) oraz 37 osób zdrowych w grupie kontrolnej (19 mężczyzn oraz 18 kobiet). W obydwu grupach wykonano następujące procedury: szczegółowy wywiad z uwzględnieniem aktywności ruchowej, diety i używek, spirometrię po leku rozszerzającym oskrzela, oznaczenie stężenia 25(OH)D w surowicy oraz w grupie badanej gazometrię krwi arterializowanej. Rekrutacja trwała od listopada do kwietnia. Analiza statystyczna została przeprowadzona za pomocą testu t-Studenta, testu U-Manna-Whitneya, korelacji porządku rang Spearmana i testu Chi-kwadrat. Wyniki: Stężenia 25(OH)D w surowicy krwi nie różniły się istotnie statystycznie pomiędzy grupą badaną a grupą kontrolną. Mediana (dolny i górny kwartyl) wyniosły odpowiednio: 24.75 nmol/L (16.9; 36.4) vs. 24.06 nmol/L (16.3; 37.2), p = 0.69. Niedobór witaminy D wystąpił u 60 chorych na POChP (98.3%) oraz 36 osób z grupy kontrolnej (97.3%), a różnica nie była znamienna statystycznie. Stężenie witaminy D nie korelowało istotnie statystycznie z żadnymi parametrami spirometrycznymi, gazometrycznymi, aktywnością, wiekiem, BMI ani paczkolatami palenia tytoniu. Natomiast oceniana aktywność korelowała dodatnio z parametrami spirometrycznymi i ujemnie z wiekiem oraz liczbą zaostrzeń. Wnioski: Wynik badania potwierdził, że w okresie jesienno-zimowym w Polsce niedobór witaminy D jest bardzo częsty nie tylko u chorych na POChP w stadium niewydolności oddechowej, ale także u osób zdrowych w podeszłym wieku. W przeciwieństwie do oczekiwań stężenia witaminy D w surowicy krwi u chorych na POChP z niewydolnością oddechową były podobne jak obserwowane w grupie kontrolnej złożonej z osób zdrowych.
    Type of Medium: Online Resource
    ISSN: 2543-6031
    URL: Article
    DOI: 10.5603/ARM.59692
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2893877-X
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  • 2
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    Role of C-C Chemokines in the Determination of Pleural Effusion Etiology
    MDPI AG ; 2008
    In:  Advances in Respiratory Medicine Vol. 76, No. 6 ( 2008-10-31), p. 415-420
    Details
    In: Advances in Respiratory Medicine, MDPI AG, Vol. 76, No. 6 ( 2008-10-31), p. 415-420
    Abstract: Introduction: Pleural effusion secondary to various diseases is associated with the presence of different inflammatory cells. The C-C chemokines (MCP-1 and MIP-1α), produced by pleural mesothelial cells, plays an important role in the recruitment of inflammatory cells to the pleural space. The purpose of the study was to evaluate predictive value of MCP-1 and MIP-1α in the differential diagnosis of pleural effusion. Material and methods: Based on Light’s criteria in 29 cases exudates and in 10 transudates were recognized. We investigated 39 patients with pleural effusion (congestive heart failure — 10, parapneumonic — 11, tuberculous — 6, malignant — 12). The C-C chemokines MCP-1 and MIP-1α levels in pleural effusion and serum were measured by ELISA. Results: The MCP-1 was significantly higher (p = 0.009) in the patient with exudates than in patients with transudates (2436 pg/ml and 794 pg/ml respectively). ROC curve analysis revealed however that this parameter has limited value in the differentiation of exudates an transudates (MCP-1 cut off value 1060 pg/ml, sensitivity 48%, specificity 90%, PPV 93%, NPV 37%). The chemokine MIP-1α were significantly higher (p = 0.001) in tuberculous than in the malignant effusion (405 pg/ml and 30 pg/ml respectively). Based on the ROC curve analysis, as a cut off value in the differentiation of tuberculous and malignant pleural effusion a value 120 pg/ml was accepted. The sensitivity of this test was 66% and specificity 99%, PPV 80%, NPV 84%. Conclusions: The chemokine MCP-1 has a limited value in the differentiation between transudate and exudates; MIP-1α could be helpful in the differentiation between tuberculous and malignant pleural effusion.
    Type of Medium: Online Resource
    ISSN: 2543-6031
    URL: Article
    DOI: 10.5603/ARM.27859
    Language: English
    Publisher: MDPI AG
    Publication Date: 2008
    detail.hit.zdb_id: 2893877-X
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  • 3
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    Risk factors of complications during noninvasive mechanical ventilation -assisted flexible bronchoscopy
    Elsevier BV ; 2021
    In:  Advances in Medical Sciences Vol. 66, No. 2 ( 2021-09), p. 246-253
    Details
    In: Advances in Medical Sciences, Elsevier BV, Vol. 66, No. 2 ( 2021-09), p. 246-253
    Type of Medium: Online Resource
    ISSN: 1896-1126
    URL: Article
    DOI: 10.1016/j.advms.2021.04.001
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2273671-2
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  • 4
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    A Real-World Multicenter Retrospective Observational Study on Polish Experience with Nintedanib Therapy in Patients with Idiopathic Pulmonary Fibrosis: The PolExNIB Study
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 14 ( 2023-07-12), p. 4635-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 14 ( 2023-07-12), p. 4635-
    Abstract: Nintedanib is a disease-modifying agent licensed for the treatment of IPF. Data on Polish experience with nintedanib in IPF are lacking. The present study aimed to describe the safety and efficacy profiles of nintedanib in a large real-world cohort of Polish patients with IPF. This was a multicenter, retrospective, observational study of IPF patients treated with nintedanib between March 2018 and October 2021. Data collection included baseline clinical characteristics, results of pulmonary function tests (PFTs), and a six-minute walk test (6MWT). Longitudinal data on PFTs, 6MWT, adverse drug reactions (ADRs), and treatment persistence were also retrieved. A total of 501 patients (70% male) with a median age of 70.9 years (IQR 65–75.7) were included in this study. Patients were followed on treatment for a median of 15 months (7–25.5). The majority of patients (66.7%) were treated with the full recommended dose of nintedanib and 33.3% of patients were treated with a reduced dose of a drug. Intermittent dose reductions or drug interruptions were needed in 20% of patients. Over up to 3 years of follow-up, pulmonary function remained largely stable with the minority experiencing disease progression. The most frequent ADRs included diarrhea (45.3%), decreased appetite (29.9%), abdominal discomfort (29.5%), weight loss (32.1%), nausea (20.8%), fatigue (19.2%), increased liver aminotransferases (15.4%), and vomiting (8.2%). A total of 203 patients (40.5%) discontinued nintedanib treatment due to diverse reasons including ADRs (10.2%), death (11.6%), disease progression (4.6%), patient’s request (6.6%), and neoplastic disease (2.2%). This real-world study of a large cohort of Polish patients with IPF demonstrates that nintedanib therapy is safe, and is associated with acceptable tolerance and disease stabilization. These data support the findings of previously conducted clinical trials and observational studies on the safety and efficacy profiles of nintedanib in IPF.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12144635
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 5
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    ANAESTHESIOLOGY AND INTENSIVE CARE Pulmonary function tests in the preoperative evaluation of lung cancer surgery candidates. A review of guidelines
    Termedia Sp. z.o.o. ; 2014
    In:  Polish Journal of Cardio-Thoracic Surgery Vol. 3 ( 2014), p. 278-282
    Details
    In: Polish Journal of Cardio-Thoracic Surgery, Termedia Sp. z.o.o., Vol. 3 ( 2014), p. 278-282
    Type of Medium: Online Resource
    ISSN: 1731-5530
    URL: Article
    DOI: 10.5114/kitp.2014.45677
    Language: Unknown
    Publisher: Termedia Sp. z.o.o.
    Publication Date: 2014
    detail.hit.zdb_id: 2237053-5
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  • 6
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    Vitamin D Status of Severe COPD Patients with Chronic Respiratory Failure
    MDPI AG ; 2018
    In:  Advances in Respiratory Medicine Vol. 86, No. 2 ( 2018-04-30), p. 78-85
    Details
    In: Advances in Respiratory Medicine, MDPI AG, Vol. 86, No. 2 ( 2018-04-30), p. 78-85
    Abstract: Introduction: The aim of the study was to measure the concentrations of vitamin D in serum of COPD patients with chronic respiratory failure in comparison to healthy control group. The correlation between the levels of vitamin D in serum and the selected clinical, spirometric and blood gas parameters was the additional aim of the study. Material and methods: The study included 61 patients with diagnosed COPD in stadium of chronic respiratory failure (45 men and 16 women) and 37 healthy controls (19 men and 18 women). The following procedure were performed in all studied subjects: detailed history (especially: daily activity, diet, tobacco and alcohol use), post-bronchodilator spirometry, assessment of 25(OH)D in serum and for COPD group only blood gas analysis. Recruitment for the study was conducted from November to April. Statistical analysis was performed using the following statistical methods: t-Student test, Mann-Whitney U test, Spearman correlation test and Chi-kwadrat test. Results: There was no significant differences between COPD and control group for the levels of 25(OH)D in serum. Median and lower; upper quartile were respectively following: 24.75 nmol/l (16.9; 36.4) vs. 24.06 nmol/l (16.3; 37.2), p = 0.69. Vitamin D deficiency was present in 60 COPD patients (98.3% of all patients) and in 36 control group subject (97.3% of all healthy volunteers). The difference was not statistically significant. The levels of vitamin D in serum did not significantly correlated with any of studied parameters (spirometry, blood gas, age, the level of activity, BMI, tobacco smoke exposure and others). However, the level of activity in COPD group correlated positively with spirometry values and negatively with age and number of exacerbations. Conclusion: The results of the study showed that in autumn-winter time in Poland there are very frequent deficiency of vitamin D in serum not only in COPD patients in respiratory failure stage but also in elderly healthy persons. However, in contrary to expectations the deficiency of vitamin D in COPD patients with respiratory failure were similar to that seen in healthy persons.
    Type of Medium: Online Resource
    ISSN: 2543-6031
    URL: Article
    DOI: 10.5603/ARM.2018.0010
    Language: English
    Publisher: MDPI AG
    Publication Date: 2018
    detail.hit.zdb_id: 2893877-X
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  • 7
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    Możliwości wnioskowania o zdolności wysiłkowej chorych na przewlekłą obturacyjną chorobę płuc na podstawie krzywej maksymalnego przepływu i objętości
    MDPI AG ; 2007
    In:  Advances in Respiratory Medicine Vol. 75, No. 3 ( 2007-07-30), p. 213-218
    Details
    In: Advances in Respiratory Medicine, MDPI AG, Vol. 75, No. 3 ( 2007-07-30), p. 213-218
    Abstract: Wstęp: Chorzy na przewlekłą obturacyjną chorobę płuc (POChP) często wykazują upośledzoną tolerancję wysiłku. Wyrazem tego jest zmniejszona zdolność wysiłkowa, którą najlepiej określić wskaźnikiem maksymalnego zużycia tlenu (V’O2max). Zależność między spoczynkowymi wskaźnikami czynności płuc a wskaźnikami zdolności wysiłkowej była przedmiotem wielu badań, jednak dotychczas nie ustalono jednoznacznie wartości predykcyjnej tych wskaźników w przewidywaniu zdolności wysiłkowej u chorych na POChP. W miarę postępu POChP kształt krzywej MEFV się zmienia. Na skutek dynamicznej kompresji dróg oddechowych podczas natężonego wydechu krzywa ta staje się coraz bardziej wklęsła w kierunku osi objętości. Celem prezentowanej pracy była ocena przydatności nowego wskaźnika, jakim jest pole powierzchni pod krzywą maksymalnego przepływu wydechowego i objętości płuc [A(ex)] , w przewidywaniu zdolności wysiłkowej (wyrażonej wskaźnikiem maksymalnego zużycia tlenu—V’O2max i maksymalnej pracy mechanicznej—Wmax). Materiał i metody: W badaniu wzięło udział 41 chorych na POChP w stadium od łagodnego do ciężkiego (FEV1 57.2 ± 15.3%N). U każdego pacjenta wykonano badanie spirometryczne, wyliczono wskaźnik A(ex), a następnie przeprowadzono limitowane objawami badanie wysiłkowe o wzrastającym obciążeniu, określając V’O2max i Wmax. Wyniki: Średnia wartość (± SD) A(ex) wynosiła 7.22 (± 4.37), a w grupie A i B odpowiednio 9.38 (± 4.54) i 4.20 (± 1.71). Wartości A(ex) między grupą A i B różniły się znamiennie (p 〈 0.0002). Stwierdzono istotną korelację między A(ex) i V’O2max (r = 0.57; p = 0.0009) w całej badanej grupie. U chorych na ciężką postać POChP stwierdzono istotną korelację między A(ex) i Wmax (r = 0.50; p = 0.04). Wnioski: Pole powierzchni pod krzywą maksymalnego przepływu wydechowego i objętości płuc [A(ex)] może być dodatkowym wskaźnikiem przydatnym w ocenie stopnia ciężkości oraz przewidywania zdolności wysiłkowej chorych na POChP.
    Type of Medium: Online Resource
    ISSN: 2543-6031
    URL: Article
    DOI: 10.5603/ARM.27969
    Language: English
    Publisher: MDPI AG
    Publication Date: 2007
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  • 8
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    Online Resource
    Therapeutic decisions in a cohort of patients with idiopathic pulmonary fibrosis: a multicenter, prospective survey from Poland
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Chronic Disease Vol. 13 ( 2022-01), p. 204062232211179-
    Details
    In: Therapeutic Advances in Chronic Disease, SAGE Publications, Vol. 13 ( 2022-01), p. 204062232211179-
    Abstract: Pirfenidone and nintedanib are considered as the standard of care in idiopathic pulmonary fibrosis (IPF), but there is no consensus as to which of these two agents should be regarded as first-line treatment. Objective: To provide real-world data on therapeutic decisions of pulmonary specialists, particularly the choice of the antifibrotic drug in patients with IPF. Methods: This was a multicenter, prospective survey collecting clinical data of patients with IPF considered as candidates for antifibrotic treatment between September 2019 and December 2020. Clinical characteristics and information on the therapeutic approach were retrieved. Statistical evaluation included multiple logistic regression analysis with stepwise model selection. Results: Data on 188 patients [74.5% male, median age 73 (interquartile range, 68–78) years] considered for antifibrotic therapy were collected. Treatment was initiated in 138 patients, while 50 patients did not receive an antifibrotic, mainly due to the lack of consent for treatment and IPF severity. Seventy-two patients received pirfenidone and 66 received nintedanib. Dosing protocol ( p  〈  0.01) and patient preference ( p = 0.049) were more frequently associated with the choice of nintedanib, while comorbidity profile ( p = 0.0003) and concomitant medication use ( p = 0.03) were more frequently associated with the choice of pirfenidone. Age ( p = 0.002), lung transfer factor for carbon monoxide (TL CO ) ( p = 0.001), and gastrointestinal bleeding ( p = 0.03) were significantly associated with the qualification for the antifibrotic treatment. Conclusion: This real-world prospective study showed that dose protocol and patient preference were more frequently associated with the choice of nintedanib, while the comorbidity profile and concomitant medication use were more frequently associated with the choice of pirfenidone. Age, TL CO , and history of gastrointestinal bleeding were significant factors influencing the decision to initiate antifibrotic therapy.
    Type of Medium: Online Resource
    ISSN: 2040-6223 , 2040-6231
    URL: Article
    DOI: 10.1177/20406223221117982
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2554816-5
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  • 9
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    Validation of Polish language version of CAT questionnaire
    "Medycyna Praktyczna" Spolka Jawna ; 2019
    In:  Polish Archives of Internal Medicine ( 2019-08-16)
    Details
    In: Polish Archives of Internal Medicine, "Medycyna Praktyczna" Spolka Jawna, ( 2019-08-16)
    Type of Medium: Online Resource
    ISSN: 1897-9483
    URL: Article
    DOI: 10.20452/pamw.14929
    Language: Unknown
    Publisher: "Medycyna Praktyczna" Spolka Jawna
    Publication Date: 2019
    detail.hit.zdb_id: 2533235-1
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  • 10
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    Evaluation of COPD Progression Based on Spirometry and Exercise Capacity
    MDPI AG ; 2013
    In:  Advances in Respiratory Medicine Vol. 81, No. 4 ( 2013-06-07), p. 288-293
    Details
    In: Advances in Respiratory Medicine, MDPI AG, Vol. 81, No. 4 ( 2013-06-07), p. 288-293
    Abstract: Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by an airflow limitation that is usually progressive. The progression of COPD expressed as the rate of an annual decline in FEV1 is very heterogeneous. Exercise capacity in COPD patients is often diminished and becomes worsened over the time. The purpose of the study was to examine how the change in FEV1 and exercise capacity would deteriorate over long-term observation. Material and Methods: A total of 22 men with COPD were examined. At the beginning the average age was 59 ± 8.1 years and the mean post-bronchodilator FEV1 was 52 ± 14.9% predicted. Pulmonary function testing was performed at entry and then each year for 10 years, and exercise testing on a cycle ergometer was performed at entry and after 10 years. Results: FEV1 and maximum oxygen uptake (VO2max), maximum mechanical work (Wmax), maximum minute ventilation (VEmax) and maximum tidal volume (VTmax) declined significantly over the observation time. The mean annual decline in FEV1 was 42 ± 37 mL, and the mean decline for VO 2max was 30 ± 15 mL/min/yr and 0.44 ± 0.25 mL/min/kg/yr. Regression analysis revealed that the changes in FEV1 do not predict changes in VO2max. We observed a correlation between the annual change in VEmax and annual change in VO2max (r = 0.51; p 〈 0.05). The baseline FEV1 (expressed as a percentage of predicted and in absolute values) is the predictor of FEV1 annual decline (r = 0.74 and 0.82; p 〈 0.05). Conclusions: We observed over time deterioration in exercise capacity in COPD patients which is independent of decline in airflow limitation. The long term follow-up of exercise capacity is important in monitoring of COPD patients in addition to pulmonary function.
    Type of Medium: Online Resource
    ISSN: 2543-6031
    URL: Article
    DOI: 10.5603/ARM.34786
    Language: English
    Publisher: MDPI AG
    Publication Date: 2013
    detail.hit.zdb_id: 2893877-X
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