In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 1 ( 2023-1-25), p. e0278685-
Abstract:
To explore the effect of glucagon-like peptide-1 receptor agonist (GLP-1 RAs) on glycemic control and weight reduction in adults. Methods Databases were searched from August 2021 to March 2022. Data were analyzed using mean difference (MD) values with 95% confidence intervals (CIs). Both random-and fixed-effect models were employed. Heterogeneity was explored using pre-specified subgroup analyses and meta-regression. Structural equation modeling fitting was used for the multivariate meta-analysis. Results A total of 31 double-blind randomized controlled trials with 22,948 participants were included in the meta-analysis. The MD and 95% CI of the pooled GLP1-RA-induced change in the glycated hemoglobin level was -0.78% (-0.97%, -0.60%) in the random-effects model and -0.45% (-0.47%, -0.44%) in the fixed-effect model, with a high heterogeneity ( I 2 = 97%). The pooled body weight reduction was -4.05 kg (-5.02 kg, -3.09 kg) in the random-effects model and -2.04 kg (-2.16 kg, -1.92 kg) in the fixed-effect model ( I 2 = 98%). The standardized pooled correlation coefficient between HbA1c levels and body weight was -0.42. A negative correlation between glycemic control and weight reduction was obtained. Conclusion Long-acting GLP-1 RAs significantly reduced the glycated hemoglobin level and body weight in adults.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0278685
DOI:
10.1371/journal.pone.0278685.g001
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10.1371/journal.pone.0278685.g002
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10.1371/journal.pone.0278685.g003
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10.1371/journal.pone.0278685.t001
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10.1371/journal.pone.0278685.t002
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10.1371/journal.pone.0278685.s001
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10.1371/journal.pone.0278685.s002
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10.1371/journal.pone.0278685.s003
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10.1371/journal.pone.0278685.s004
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10.1371/journal.pone.0278685.s005
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10.1371/journal.pone.0278685.s007
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10.1371/journal.pone.0278685.s008
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10.1371/journal.pone.0278685.s009
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10.1371/journal.pone.0278685.s010
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10.1371/journal.pone.0278685.s011
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10.1371/journal.pone.0278685.s012
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10.1371/journal.pone.0278685.s013
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10.1371/journal.pone.0278685.s014
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10.1371/journal.pone.0278685.r001
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10.1371/journal.pone.0278685.r002
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10.1371/journal.pone.0278685.r003
DOI:
10.1371/journal.pone.0278685.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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