In:
Hepatology Research, Wiley, Vol. 44, No. 3 ( 2014-03), p. 327-337
Abstract:
We aimed to elucidate the relationship between the contrast enhancement effect of gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid ( G d‐ EOB‐DTPA ) on magnetic resonance imaging ( MRI ) of hepatocellular carcinomas ( HCC ) and the expressions of hepatocyte transporters (i.e. organic anion‐transporting polypeptide [ OATP ] 1B3 , multidrug‐resistant protein [ MRP ]2 and MRP3 ) and to clarify the characteristics of HCC with an MRI high‐contrast enhancement effect. Methods We retrospectively examined the relationship between the relative enhancement ratio ( RER ) of HCC , absolute and relative immunohistochemical staining scores of hepatocyte transporters, and histological differentiation of 22 HCC from 21 patients who had undergone preoperative G d‐ EOB‐DTPA ‐enhanced MRI . Results RER had a significant correlation with OATP1B3 expression according to the absolute and relative scores ( P = 0.016 vs 0.0006). The RER of HCC with high OATP1B3 and MRP2 expression levels was higher than that of HCC with low OATP1B3 or MRP2 expression levels ( P = 0.0003). The RER of HCC with higher OATP1B3 rates was greater than that of HCC with lower OATP1B3 rates ( P = 0.0005). HCC histological differentiation showed a significant correlation with OATP1B3 expression and RER ( P = 0.023 vs 0.0095). Conclusion We found that coexpression of OATP1B3 and MRP2 influenced the high contrast enhancement of HCC on MRI .
Type of Medium:
Online Resource
ISSN:
1386-6346
,
1872-034X
DOI:
10.1111/hepr.2014.44.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2006439-1
Bookmarklink