In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 63, No. 6 ( 2002-06-01), p. 804-810
Abstract:
Objective —To determine whether small intestinal
ischemia and reperfusion affects intestinal intramucosal pH (pHi), arterial and portal venous blood gas
values, and intestinal blood flow (IBF) and to investigate relationships between regional intestinal tissue
oxygenation and systemic variables in dogs. Animals —15 healthy adult Beagles. Procedure —Occlusion of superior mesenteric artery
(SMA) for 0, 30, or 60 minutes, followed by reperfusion for 180 minutes, was performed; IBF, pHi, arterial and
portal venous blood gas values, arterial pressure, and heart rate were measured at various time points; and
intestinal mucosal injury was histologically graded. Results —Occlusion of the SMA induced significant
decreases in pHi and IBF. After the release of the occlusion, IBF returned rapidly to baseline values, but
improvement in pHi was slow. Arterial and portal venous blood gas analyses were less sensitive than
tonometric measurements of pHi, and there was no correlation between results of blood gas analyses and
tonometric measurements. Histologic score for intestinal mucosal injury increased significantly, depending
on duration of ischemia, and there was a correlation between tonometric results and the histologic score. Conclusion and Clinical Relevance —Results suggest
that it is difficult to accurately evaluate local oxygenation disorders by monitoring at the systemic
level, whereas clinically pHi is the only reliable indicator of inadequate regional intestinal tissue oxygenation
in dogs. ( Am J Vet Res 2002;63:804–810)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2002.63.804
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2002
detail.hit.zdb_id:
2056942-7
SSG:
22
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