In:
Science, American Association for the Advancement of Science (AAAS), Vol. 376, No. 6596 ( 2022-05-27), p. 934-936
Abstract:
The oral microbiota is shaped by mutualistic coevolution with the host and by the distinct physiology of the mouth. In an evolutionary quid pro quo, the host provides the commensal bacteria with a stable ecological niche and in return the oral microbiota supports host health locally by forming symbiotic biofilms that balance pH levels and suppress pathogen growth, as well as potentially by systemically reinforcing the body’s physiological processes, such as cardiovascular homeostasis. However, when a biofilm transforms into a dysbiotic state, which is no longer in homeostatic equilibrium with the host, the oral microbiota may contribute to the pathological processes of a wide range of diseases, including inflammatory bowel disease (IBD), arthritis, colorectal and pancreatic cancers, and Alzheimer’s disease, by serving as a reservoir for opportunistic pathogens. This in turn presents opportunities to identify predictive disease biomarkers within the oral microbiota and the development of intervention strategies to promote oral and overall health.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.abn1890
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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