In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 100, No. 3 ( 1982-07), p. 462-472
Abstract:
The effect of the antioestrogen tamoxifen (TA) was investigated in different types of steroid-induced benign prostatic hyperplasia (BPH) in the castrated dog by histological, histochemical and biochemical analysis. A 6 months treatment with oestradiol-17β (E 2 ) alone resulted in cystic and stromal hyperplasia and squamous epithelial metaplasia with a striking prostatic weight increase. DNA and RNA content of the total glands increased significantly. The histochemical results and zinc values indicated the loss of normal epithelial function due to metaplatic transformation. The E 2 induced cystic and metaplastic hyperplasia was prevented by TA while the stromal proliferation was significantly decreased but not abolished. Biochemical determinations revealed an effect similar to castration. After combined treatment with E 2 and 3α-androstanediol (3α-diol) TA completely suppressed squamous metaplasia. A 3α-diol induced glandular proliferation, monitored by a positive histochemical reaction, and significantly elevated zinc, DNA and RNA contents prevailed. A partial stromal stimulation indicates stimulating effects of 3α-diol too on the stroma. The antioestrogenic effects of tamoxifen on experimentally induced BPH mainly manifest at the E 2 induced epithelial alterations. The abolishing effects at the stromal level are distinct but not so impressive.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.1000462
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1982
detail.hit.zdb_id:
1485160-X
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