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Tapering body stiffness shortens upper gastrointestinal examination via transoral insertion with ultrathin endoscope

Ono, Satoshi ; Ito, Shun ; Maejima, Kyohei ; [et al.]

Georg Thieme Verlag KG ; 2020

In: Endoscopy International Open Vol. 08, No. 12 ( 2020-12), p. E1748-E1753

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In: Endoscopy International Open, Georg Thieme Verlag KG, Vol. 08, No. 12 ( 2020-12), p. E1748-E1753

Abstract: Background and study aims Ultrathin endoscopes are commonly used for surveillance esophagogastroduodenoscopy (EGD) to reduce discomfort associated with scope insertion. However, the flexibility of an ultrathin endoscope is a trade-off between reducing discomfort and lengthening examination time. Patients and methods The EG17-J10 (EG17) is a novel ultrathin endoscope characterized by its tapering body stiffness; however, the flexibility of its tip is comparable to that of the traditional ultrathin endoscope EG16-K10 (EG16). We compared EGD examination time between EG17 and EG16. A total of 319 examinees who underwent EGD from November 2019 to January 2020 at the Chiba-Nishi General Hospital were enrolled. Six examinees were excluded due to past history of surgical resection of the upper gastrointestinal tract or too much food residues; 313 examinees (EG17, 209; EG16,104) were retrospectively analyzed. The examination time was divided into three periods: esophageal insertion time (ET), gastroduodenal insertion time (GDT), and surveillance time of the stomach (ST). The total amount of ET, GDT, and ST was defined as total examination time (TT). Results TT of EGD using EG17 was significantly shorter compared to EGD using EG16 (222.7 ± 68.9 vs. 245.7 ± 78.5 seconds) (P = 0.004). Among the three periods of examination time, ET (66.7 ± 24.1 vs. 76.0 ± 24.1 seconds) (P = 0.001) and GDT (47.9 ± 17.4 vs. 55.2 ± 35.2 seconds) (P = 0.007) of EGD using EG17 were significantly shorter compared to EGD using EG16, except for ST (108.1 ± 51.5.1 vs. 114.5 ± 50.1 seconds) (P = 0.148). Conclusion An ultrathin endoscope with tapering body stiffness can shorten EGD examination time, mainly due to the shortening of insertion time.

Type of Medium: Online Resource

ISSN: 2364-3722 , 2196-9736

URL: Article

DOI: 10.1055/a-1266-3203

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2020

detail.hit.zdb_id: 2761052-4

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Self-study of the non-extension sign in an e-learning program improves diagnostic accuracy of invasion depth of early gastric cancer

Kato, Minoru ; Uedo, Noriya ; Nagahama, Takashi ; [et al.]

Georg Thieme Verlag KG ; 2019

In: Endoscopy International Open Vol. 07, No. 07 ( 2019-07), p. E871-E882

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In: Endoscopy International Open, Georg Thieme Verlag KG, Vol. 07, No. 07 ( 2019-07), p. E871-E882

Abstract: Background and study aims We developed an e-learning program for endoscopic diagnosis of invasion depth of early gastric cancer (EGC) using a simple diagnostic criterion called non-extension sign, and the contribution of self-study quizzes to improvement of diagnostic accuracy was evaluated. Methods We conducted a prospective randomized controlled study that recruited endoscopists throughout Japan. After completing a pretest, the participants watched video lectures and undertook post-test 1. The participants were then randomly allocated to either the self-study or non-self-study group, and participants in the first group completed the self-study program that comprised 100-case quizzes. Finally, participants in both groups undertook post-test 2. The primary endpoint was the difference in post-test 2 scores between the groups. The perfect score for the tests was set as 100 points. Results A total of 423 endoscopists completed the pretest and were enrolled. Post-test 1 was completed by 415 endoscopists and 208 were allocated to the self-study group and 207 to the non-self-study group. Two hundred and four in the self-study group and 205 in the non-self-study group were included in the analysis. Video lectures improved the mean score of post-test 1 from 72 to 77 points. Participants who completed the self-study quizzes showed significantly better post-test 2 scores compared with the non-self-study group (80 vs. 76 points, respectively, P 〈 0.0001). Conclusions Our e-learning program showed that self-study quizzes consolidated knowledge of the non-extension sign and improved diagnostic ability of endoscopists for invasion depth of EGC.

Type of Medium: Online Resource

ISSN: 2364-3722 , 2196-9736

URL: Article

DOI: 10.1055/a-0902-4467

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2019

detail.hit.zdb_id: 2761052-4

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Lemmel症候群に対し直視鏡を用いた残渣除去が有効であった一例

Ito, Shun ; Umeki, Kiyotaka ; Hosaka, Shosuke ; [et al.]

Japan Gastrointestinal Endoscopy Society ; 2019

In: Progress of Digestive Endoscopy Vol. 95, No. 1 ( 2019-12-20), p. 68-71

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In: Progress of Digestive Endoscopy, Japan Gastrointestinal Endoscopy Society, Vol. 95, No. 1 ( 2019-12-20), p. 68-71

Type of Medium: Online Resource

ISSN: 1348-9844 , 2187-4999

URL: Article

DOI: 10.11641/pde.95.1_68

Language: English

Publisher: Japan Gastrointestinal Endoscopy Society

Publication Date: 2019

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Withコロナ時代の内視鏡検診におけるCOVID19スクリーニング検査に関する検討

Maejima, Kyouhei ; Ono, Satoshi ; Ito, Shun ; [et al.]

Japan Gastrointestinal Endoscopy Society ; 2021

In: Progress of Digestive Endoscopy Vol. 99, No. 1 ( 2021-12-3), p. 41-46

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In: Progress of Digestive Endoscopy, Japan Gastrointestinal Endoscopy Society, Vol. 99, No. 1 ( 2021-12-3), p. 41-46

Type of Medium: Online Resource

ISSN: 1348-9844 , 2187-4999

URL: Article

DOI: 10.11641/pde.99.1_41

Language: English

Publisher: Japan Gastrointestinal Endoscopy Society

Publication Date: 2021

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Allosteric regulation by cooperative conformational changes of actin filaments drives mutually exclusive binding with cofilin and myosin

Ngo, Kien Xuan ; Umeki, Nobuhisa ; Kijima, Saku T. ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Scientific Reports Vol. 6, No. 1 ( 2016-10-20)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-10-20)

Abstract: Heavy meromyosin (HMM) of myosin II and cofilin each binds to actin filaments cooperatively and forms clusters along the filaments, but it is unknown whether the two cooperative bindings are correlated and what physiological roles they have. Fluorescence microscopy demonstrated that HMM-GFP and cofilin-mCherry each bound cooperatively to different parts of actin filaments when they were added simultaneously in 0.2 μM ATP, indicating that the two cooperative bindings are mutually exclusive. In 0.1 mM ATP, the motor domain of myosin (S1) strongly inhibited the formation of cofilin clusters along actin filaments. Under this condition, most actin protomers were unoccupied by S1 at any given moment, suggesting that transiently bound S1 alters the structure of actin filaments cooperatively and/or persistently to inhibit cofilin binding. Consistently, cosedimentation experiments using copolymers of actin and actin-S1 fusion protein demonstrated that the fusion protein affects the neighboring actin protomers, reducing their affinity for cofilin. In reciprocal experiments, cofilin-actin fusion protein reduced the affinity of neighboring actin protomers for S1. Thus, allosteric regulation by cooperative conformational changes of actin filaments contributes to mutually exclusive cooperative binding of myosin II and cofilin to actin filaments, and presumably to the differential localization of both proteins in cells.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/srep35449

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2615211-3

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A case of successful full-thickness resection using endoscopic submucosal dissection and transanal suturing of rectal cancer

Ono, Satoshi ; Kobayashi, Ryosuke ; Ito, Shun ; [et al.]

Georg Thieme Verlag KG ; 2019

In: Endoscopy Vol. 51, No. 10 ( 2019-10), p. E301-E302

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In: Endoscopy, Georg Thieme Verlag KG, Vol. 51, No. 10 ( 2019-10), p. E301-E302

Type of Medium: Online Resource

ISSN: 0013-726X , 1438-8812

URL: Article

DOI: 10.1055/a-0915-1847

RVK:

XA 41100

RVK:

YC 4905

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2019

detail.hit.zdb_id: 2026213-9

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G146V Mutation at the Hinge Region of Actin Reveals a Myosin Class-specific Requirement of Actin Conformations for Motility

Noguchi, Taro Q.P. ; Komori, Tomotaka ; Umeki, Nobuhisa ; [et al.]

Elsevier BV ; 2012

In: Journal of Biological Chemistry Vol. 287, No. 29 ( 2012-07), p. 24339-24345

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 287, No. 29 ( 2012-07), p. 24339-24345

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M111.321752

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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Efficacy and safety of short-term therapy with indigo naturalis for ulcerative colitis: An investigator-initiated multicenter double-blind clinical trial

Uchiyama, Kan ; Takami, Shinichiro ; Suzuki, Hideo ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS ONE Vol. 15, No. 11 ( 2020-11-5), p. e0241337-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2020-11-5), p. e0241337-

Abstract: Indigo naturalis (IN) is a blue pigment extracted from Assam indigo and other plants and has been confirmed to be highly effective for ulcerative colitis (UC) treatment in several clinical studies. Objective We conducted a multicenter double-blind study to confirm the efficacy and safety of short-term IN administration. Methods A multicenter, randomized controlled trial was conducted between December 2015 and October 2018 in our facilities. Forty-six patients with mild to moderate active UC (Lichtiger index: 5–10) were randomly assigned to the IN group or the placebo group and received 5 capsules (500 mg) twice a day for 2 weeks. We investigated the efficacy according to blood tests and the Lichtiger index before and after administration, and we also examined adverse events. Results The analysis included 42 patients (20 males, 22 females) with an average age of 45 years. Nineteen patients were assigned to the placebo group, and 23 were assigned to the IN group. After treatment administration, in the placebo group, no change in the Lichtiger index was observed (7.47 to 6.95, p = 0.359), and hemoglobin was significantly reduced (12.7 to 12.4, p = 0.031), while in the IN group, the Lichtiger index (9.04 to 4.48, p = 0.001) and albumin (4.0 to 4.12, p = 0.022) improved significantly. Mild headaches were observed in 5 patients and 1 patient in the IN and placebo groups, respectively. Conclusions Short-term administration of IN is highly effective without serious adverse events such as pulmonary hypertension or intussusception and may prevent the occurrence of serious adverse events.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0241337

DOI: 10.1371/journal.pone.0241337.g001

DOI: 10.1371/journal.pone.0241337.g002

DOI: 10.1371/journal.pone.0241337.g003

DOI: 10.1371/journal.pone.0241337.g004

DOI: 10.1371/journal.pone.0241337.g005

DOI: 10.1371/journal.pone.0241337.t001

DOI: 10.1371/journal.pone.0241337.t002

DOI: 10.1371/journal.pone.0241337.s001

DOI: 10.1371/journal.pone.0241337.s002

DOI: 10.1371/journal.pone.0241337.s003

DOI: 10.1371/journal.pone.0241337.s004

DOI: 10.1371/journal.pone.0241337.s005

DOI: 10.1371/journal.pone.0241337.r001

DOI: 10.1371/journal.pone.0241337.r002

DOI: 10.1371/journal.pone.0241337.r003

DOI: 10.1371/journal.pone.0241337.r004

DOI: 10.1371/journal.pone.0241337.r005

DOI: 10.1371/journal.pone.0241337.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2267670-3

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Snare devices with thinner loop wire may provide higher performance for cold snare polypectomy in an experimental model

Ono, Satoshi ; Maejima, Kyohei ; Ito, Shun ; [et al.]

Georg Thieme Verlag KG ; 2022

In: Endoscopy International Open Vol. 10, No. 05 ( 2022-05), p. E664-E669

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In: Endoscopy International Open, Georg Thieme Verlag KG, Vol. 10, No. 05 ( 2022-05), p. E664-E669

Abstract: Background and study aims Snare devices play an important role in treatment of intestinal polyps. However, there are no objective measurements for the characteristics of the various types of snare devices. Materials and methods Seven types of snare devices from four manufacturers were evaluated based on original measurements. The evaluated factors were stiffness, cutting quality, and change in force required for cutting depending on sheath shape. The latter two factors were evaluated by measuring the force required to cut 20 % gelatin cylinders, which simulated intestinal polyps. The cutting sharpness was evaluated by observing the sectional surface of cut gelatin cylinders using a stereomicroscope. The correlations between these measurements and characteristics of the snare devices were investigated. Results A strong positive correlation, with an R2 value of 0.863, was shown between the force required to cut gelatin cylinders and loop wire diameter. Loop wire diameter also had a strong correlation, with an R2 value of 0.7997, with the change in force required for cutting gelatin cylinders depending on sheath shape. No correlations were detected between loop stiffness and characteristics of snare devices. The edge-enhanced image revealed that the rougher surfaces of the gelatin cylinders were cut by snares with a thicker diameter. Conclusions Thinner loop wire may provide higher performance in cold snare polypectomy in an experimental model.

Type of Medium: Online Resource

ISSN: 2364-3722 , 2196-9736

URL: Article

DOI: 10.1055/a-1793-9232

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2022

detail.hit.zdb_id: 2761052-4

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Solid pseudopapillary neoplasm in the pancreatic head in a young male

HASEGAWA, Kei ; WATANABE, Hidejiro ; KUBO, Koichiro ; [et al.]

Japan Pancreas Society ; 2013

In: Suizo Vol. 28, No. 1 ( 2013), p. 67-73

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In: Suizo, Japan Pancreas Society, Vol. 28, No. 1 ( 2013), p. 67-73

Type of Medium: Online Resource

ISSN: 0913-0071 , 1881-2805

Uniform Title: 若年男性に発症した膵頭部Solid pseudopapillary neoplasmの1例

URL: Article

DOI: 10.2958/suizo.28.67

Language: English , Japanese

Publisher: Japan Pancreas Society

Publication Date: 2013

detail.hit.zdb_id: 2433526-5

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