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  • 1
    Online Resource
    Online Resource
    Lahore Medical and Dental College ; 2023
    In:  Pakistan Journal of Medical and Health Sciences Vol. 17, No. 3 ( 2023-04-29), p. 646-648
    In: Pakistan Journal of Medical and Health Sciences, Lahore Medical and Dental College, Vol. 17, No. 3 ( 2023-04-29), p. 646-648
    Abstract: Objectives: To evaluate the incidence of serum vitamin D insufficiency in patients with psoriasis and study the relationship between dietary intake of vitamin D and clinical characteristics. Materials and Methods: Totally eighty individuals were enrolled and were equally divided into two groups (40 patients in each group): Group A consisted of psoriasis patients, whereas Group B consisted of controls. By using the PASI scale, psoriasis plaques were identified and assessed. The predesign questionnaire was developed and was given to each participant to complete it. Age, gender, the length of the psoriasis, concurrent illnesses, and medications were among the collected data. A dermatologist examined all of the patients and gathered information about their demographics, health, and any other pertinent information. Blood samples were taken to measure the level of serum vitamin D using the immuno-enzyme method. All measurements were conducted during winter months to avoid the influence of sun exposure on synthesis of vitamin D3 and its derivative 25-hydroxycholecalciferol. SPSS (v 25.0) was used for analysis and the results were shown in the form of graph and table. Results: Statistically significant difference was found in 25(OH) D3 levels between psoriasis affected individuals and healthy individuals. Both groups have low level of 25-hydroxycholecalciferol. In our results there is negative correlation between 25(OH) D3 and PASI. There is also a negative correlation between 25(OH) D3 and duration of psoriasis. Practical implication: This study will help the clinical practitioner to advise the patients with psoriasis to use enough amounts of vitamin D3 that will help to normalize the vitamin D level in patients. It is believed that psoriasis can cause a progressive decrease in the level of vitamin D3 derivatives in the whole human body, including the skin. So vitamin D rich food must be eaten in high amount. Conclusion: It is found in this study that both the groups have low serum vitamin D3 level. Both the general public and persons with psoriasis should eat enough amounts of vitamin D3. Keywords: PASI, vitamin D3, Psoriasis, serum, antiproliferative,
    Type of Medium: Online Resource
    URL: Issue
    Language: Unknown
    Publisher: Lahore Medical and Dental College
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Peertechz Publications Private Limited ; 2023
    In:  International Journal of Dermatology and Clinical Research Vol. 9, No. 1 ( 2023-03-22), p. 001-006
    In: International Journal of Dermatology and Clinical Research, Peertechz Publications Private Limited, Vol. 9, No. 1 ( 2023-03-22), p. 001-006
    Abstract: Background: Recessively inherited X-linked Ichthyosis (XLI) is the second most generic form of Ichthyosis and is characterized by scaly, dry, thickened, and mild erupted skin. It is caused by a mutation in the STS gene ensuing lower production of Steroid sulfatase. A current study was performed to characterize XLI and its complications in patients of Bajaur Agency, Pakistan. We also wanted to record critical factors affecting the progression of XLI. Methods: An Ichthyosis examination questionnaire was prepared and detailed information about the symptoms and management was recorded from 51 affected male patients of 17 families. Personal data such as age and gender were also recorded. Results: Our results indicate that 53% of the patients were collodion while other symptoms appeared in the first month after birth. Almost every part of the patient has symptoms of the disease; scales were found on the extensor and flexor muscles (98%) of limbs followed by the ears (82.53%). All the patients had normal nails, palms and soles. Conclusion: The age of the patients seems to have a significant effect on the color of the scales changing from white to brown to blackish. The disease progresses with the age and worsens in cold, dry seasons. The pedigrees of all families show that disease passes from generation to generation according to the classical X-linked recessive inheritance. We recommend early diagnosis and treatment for effective management of the condition. Further work is required to elucidate the genetic, biochemical, and environmental factors involved in the disease.
    Type of Medium: Online Resource
    ISSN: 2455-8605
    Language: Unknown
    Publisher: Peertechz Publications Private Limited
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Dewspublication ; 2023
    In:  Journal of Namibian Studies : History Politics Culture Vol. 34 ( 2023-06-19), p. 1532-1544
    In: Journal of Namibian Studies : History Politics Culture, Dewspublication, Vol. 34 ( 2023-06-19), p. 1532-1544
    Abstract: This research paper delves into the novel "The Heart of Darkness" by Joseph Conrad, examining it through a post-colonial lens to explore the themes of liberation and the impact of colonialism on various aspects of life. The analysis chapter investigates crucial subtopics such as the dream-like existence and passivity of the colonial settlers, the exploitation of power and the weaknesses of the colonized, the lives of subalterns, the imposition of new systems, and the loss of freedom. Additionally, it examines the darkness of life and the insignificance of native culture, along with the legitimization of invasion and occupation and the voice of resistance. The study adopts a qualitative research methodology, drawing on post-colonial theories presented by scholars such as Edward Said, Gayatri Chakravorty Spivak, Homi K. Bhabha, and Frantz Fanon (Said, 1978; Spivak, 1993; Bhabha, 2008; Fanon, 2008). These theories serve as a theoretical framework, guiding the textual analysis to uncover and interpret post-colonial structures and themes present in the novel. By employing these perspectives, the study seeks to understand the complexities of colonial relationships, encompassing traditions, norms, identity, culture, and experiences depicted in the portrayal of both colonizers and the colonized. The main analytical tool used in this research is Edward Said's theory of Orientalism, supplemented by insights from other post-colonial theorists (Edward, 1978). The data collection process involves a comprehensive study of the novel and the selected theories, and relevant text materials from the novel are carefully chosen based on the elements of the adopted theories. The primary sources of data include Joseph Conrad's "The Heart of Darkness," as well as the works of Spivak, Said, Bhabha, and Fanon (Conrad, 1902; Said, 1978; Spivak, 1993; Bhabha, 2008; Fanon, 2008). The research paper presents a qualitative data analysis technique, focusing on themes such as orientalism, racism, identity, subalternity, and hybridity. After thorough examination and interpretation of the novel's text in light of the selected theories, the paper offers critical insights into the post-colonial elements present in "The Heart of Darkness." This study contributes to the broader understanding of post-colonial literature and highlights the lasting impacts of colonialism on both the colonized and the colonizers.
    Type of Medium: Online Resource
    ISSN: 2197-5523 , 1863-5954
    Language: Unknown
    Publisher: Dewspublication
    Publication Date: 2023
    detail.hit.zdb_id: 2686690-0
    SSG: 8
    SSG: 6,31
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  • 4
    Online Resource
    Online Resource
    Informa UK Limited ; 2020
    In:  Immunopharmacology and Immunotoxicology Vol. 42, No. 3 ( 2020-05-03), p. 255-263
    In: Immunopharmacology and Immunotoxicology, Informa UK Limited, Vol. 42, No. 3 ( 2020-05-03), p. 255-263
    Type of Medium: Online Resource
    ISSN: 0892-3973 , 1532-2513
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2085320-8
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  • 5
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2016-12)
    Type of Medium: Online Resource
    ISSN: 1471-2334
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2041550-3
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  • 6
    In: Frontiers in Materials, Frontiers Media SA, Vol. 10 ( 2023-3-13)
    Abstract: The current communication, manifest mathematical modelling and numerical computations of Sutterby nanofluids with radiant heat assessment subject to heat generation/absorption. The thermophoresis and Brownian motion effects are incorporated via the Buongiorno model in flow governing equations. Moreover, the present analysis reveals the impacts of thermal stratification, velocity slip, and a magnetic field on flow phenomena. The non-Newtonian nature is modelled using Sutterby fluid. The proposed model is formulated mathematically through basic partial differential equations relating mass, momentum, energy, and nanoparticle concentration conservations using boundary layer theory. We adapted the generated governed equations to ordinary differential equations utilizing similarity variables mechanism. Numerical treatment for the reduced system of ordinary differential equations is performed using the built-in MATLAB code bvp4c. The impacts of distinct characterizing parameters on velocity, temperature, and concentration profiles are determined and analyzed via graphs. The existence of velocity slip parameter, fluid flow is significantly dwindle, while the surface friction growth is sophisticated. Brownian and thermophoresis mechanisms degrade the heat transmission rate and escalate the mass flux. The thermal and solutal stratification exhibits opposite conduct for thermal and concentration of the nanoparticles.
    Type of Medium: Online Resource
    ISSN: 2296-8016
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2759394-0
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  • 7
    In: Archives of Agronomy and Soil Science, Informa UK Limited, Vol. 67, No. 13 ( 2021-11-10), p. 1889-1900
    Type of Medium: Online Resource
    ISSN: 0365-0340 , 1476-3567
    RVK:
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2068377-7
    detail.hit.zdb_id: 121282-5
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  • 8
    In: Optics Express, Optica Publishing Group, Vol. 29, No. 3 ( 2021-02-01), p. 3873-
    Abstract: Aflatoxin M1 (AFM1) is a carcinogenic compound commonly found in milk in excess of the WHO permissible limit, especially in developing countries. Currently, state-of-the-art tests for detecting AFM1 in milk include chromatographic systems and enzyme-linked-immunosorbent assays. Although these tests provide fair accuracy and sensitivity, they require trained laboratory personnel, expensive infrastructure, and many hours to produce final results. Optical sensors leveraging spectroscopy have a tremendous potential of providing an accurate, real-time, and specialist-free AFM1 detector. Despite this, AFM1 sensing demonstrations using optical spectroscopy are still immature. Here, we demonstrate an optical sensor that employs the principle of cavity attenuated phase shift spectroscopy in optical fiber cavities for rapid AFM1 detection in aqueous solutions at 1550 nm. The sensor constitutes a cavity built by two fiber Bragg gratings. We splice a tapered fiber of 〈 10 μ m waist inside the cavity as a sensing head. For ensuring specific binding of AFM1 in a solution, the tapered fiber is functionalized with DNA aptamers followed by validation of the conjugation via FTIR, TGA, and EDX analyses. We then detect AFM1 in a solution by measuring the phase shift between a sinusoidally modulated laser input and the sensor output at resonant frequencies of the cavity. Our results show that the sensor has the detection limit of 20 ng/L (20 ppt), which is well below both the U.S. and the European safety regulations. We anticipate that the present work will lead towards a rapid and accurate AFM1 sensor, especially for low-resource settings.
    Type of Medium: Online Resource
    ISSN: 1094-4087
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2021
    detail.hit.zdb_id: 1491859-6
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  • 9
    Online Resource
    Online Resource
    IDEA PUBLISHERS ; 2022
    In:  Natural and Applied Sciences International Journal (NASIJ) Vol. 3, No. 2 ( 2022-12-31), p. 30-41
    In: Natural and Applied Sciences International Journal (NASIJ), IDEA PUBLISHERS, Vol. 3, No. 2 ( 2022-12-31), p. 30-41
    Abstract: The purpose of the built environment had always been focused on protection from external hostilities (wild creatures, worse climatic conditions, etc.) and internal comfort. Recent studies suggest another spectrum regarding the physical and psychological implications of the built environment. As a specialised and crossed-disciplinary research area, the results are less than often conveyed and incorporated in the planning design practice. This research aims to develop a comprehensive base about the implications of the built environment for incorporation in future planning and design. The evidence-based design approach was used based on the extraction and analysis of published research from JSTOR, Google Scholar, PubMed, and Scopus through single and combined keyword searches, like the evidence-based design; architecture and health; impacts of layouts; social capital; healing environment; stress reduction; social support; views of nature; daylighting; urban planning and health etc. The data was analysed for different levels of evidence, and only those studies having excellent, good, and fair levels of evidence were included. The results were broadly categorised into two levels: the macro-level (urban and regional planning) and the micro-level (architectural level). The results of this study may improve the existing and future planning and design.
    Type of Medium: Online Resource
    ISSN: 2788-4619 , 2788-4619
    Language: Unknown
    Publisher: IDEA PUBLISHERS
    Publication Date: 2022
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  • 10
    Online Resource
    Online Resource
    Horizon Publisher India ; 2020
    In:  South Asian Journal of Experimental Biology Vol. 10, No. 4 ( 2020-08-02), p. 243-248
    In: South Asian Journal of Experimental Biology, Horizon Publisher India, Vol. 10, No. 4 ( 2020-08-02), p. 243-248
    Abstract: Growing concerns about the spread of multidrug-resistant tuberculosis (MDR-TB) and the emergence of extensively drug-resistant TB have triggered substantial interest in the development and application of rapid tests for the detection of drug-resistant TB. Molecular assays to detect gene mutations that signal drug resistance are widely recognized as being most suited for rapid diagnosis. Among molecular assays, line probe assays (LPA) have shown great promise. In this study, we have tested eight hundred thirty smear positive sputum samples by LPA for the presence of M. tuberculosis complex and resistance to isoniazid and rifampicin as per the diagnostic mandate of an accredited reference laboratory. As per the mandate, samples that were positive for M. tuberculosis complex were cultured, and then again tested by LPA. A retrospective analysis of the results was carried out. M. tuberculosis complex could be detected in 797 (96.02%) but not in 33 (3.9%) of smear-positive sputum samples. Of the 797 positive samples, 24 (3.0%) were MDR, 6 (0.75%) were rifampicin mono-resistant and 33(4.1%) were INH mono-resistant. LPAs have a continued role for use in settings where rapid identification of INH resistance and clinically relevant NTM are priorities.
    Type of Medium: Online Resource
    ISSN: 2230-9799
    URL: Issue
    Language: Unknown
    Publisher: Horizon Publisher India
    Publication Date: 2020
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