In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. Suppl_1 ( 2021-11-16)
Abstract:
Introduction: Low skeletal muscle area or density identified on computed tomography (CT) is associated with poor prognosis in patients with cardiovascular disease. However, there is a lack of evidence regarding the clinical process of skeletal muscle decline as a longitudinal change in the acute care setting. Hypothesis: Skeletal muscle loss occurs after acute care, and a high degree of skeletal muscle loss is associated with an insufficient recovery of physical function. Methods: This study used routinely acquired CT images for aortic disease management and prospectively reviewed the data of 123 patients who underwent abdominal CT before and after acute care. The area and density of all abdominal muscles and each muscle (such as the rectus abdominis, psoas, and erector spinae) divided into eight parts were measured at the third lumbar vertebra level after patient blinding. The short physical performance battery (SPPB) was used as a physical function parameter at the start and end of in-hospital cardiac rehabilitation. A generalized linear model with patients as random effects was used to investigate skeletal muscle loss during acute care. Multivariate linear regression analysis was performed to assess the relationship between skeletal muscle decline during acute care and the change in SPPB results during inpatient cardiac rehabilitation. Results: The median patient age was 70 years, and 70% of patients were men. All and each abdominal muscle density declined consistently after acute care (interaction: P = 0.998). In contrast, the whole muscle area was found to have no significant change, and the changes were different for each skeletal muscle (interaction: P = 0.037). After adjusting for confounding factors, greater declines in muscle density were associated with lower recovery on the SPPB (β = 0.30, P = 0.007). Conclusions: Muscle density declines consistently after acute care, and a greater decline in muscle density is associated with a lower recovery of physical function during in-hospital cardiac rehabilitation in patients with aortic disease.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.144.suppl_1.11116
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
1466401-X
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