In:
Pediatrics International, Wiley, Vol. 57, No. 3 ( 2015-06), p. 498-500
Abstract:
In these case series, we report on six children (3 girls, 3 boys) aged 5–13 years with Henoch–Schönlein purpura (HSP) who developed severe gastrointestinal (GI) bleeding resistant to both 2 mg/kg or pulse (10–30 mg/kg) i.v. methylprednisolone. All patients responded to single‐dose (500 mg/m 2 ) i.v. cyclophosphamide (CPA) and none of them developed new GI bleeding after CPA treatment. No patients required surgical intervention. Single high‐dose CPA may be beneficial in HSP with severe GI involvement, in which bleeding is non‐responsive to high‐dose steroids.
Type of Medium:
Online Resource
ISSN:
1328-8067
,
1442-200X
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2008621-0
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