In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 5 ( 2023-5-17), p. e0283278-
Abstract:
The association between blood glucose level and cerebral oxygenation (cerebral regional oxygen saturation [crSO 2 ] and cerebral fractional tissue oxygen extraction [FTOE] ) in neonates has already been described. Aim of the present study was to investigate if acid-base and other metabolic parameters have an impact on cerebral oxygenation immediately after birth in preterm and term neonates. Study design Post-hoc analyses of secondary outcome parameters of two prospective observational studies were performed. Preterm and term neonates born by caesarean section were included, in whom i) cerebral near-infrared spectroscopy (NIRS) measurements were performed during the first 15 minutes after birth and ii) a capillary blood gas analysis was performed between 10 and 20 minutes after birth. Vital signs were routinely monitored with pulse oximetry (arterial oxygen saturation [SpO 2 ] and heart rate [HR] ). Correlation analyses were performed to investigate potential associations between acid-base and metabolic parameters (lactate [LAC], pH-value [pH] , base-excess [BE] and bicarbonate [HCO 3 ]) from capillary blood and NIRS-derived crSO 2 and FTOE at 15 minutes after birth. Results One-hundred-fifty-seven neonates, 42 preterm neonates (median gestational age [IQR] 34.0 weeks [3.3] , median birth weight 1845g [592]) and 115 term neonates (median gestational age [IQR] 38.9 weeks [1.0], median birth weight 3230g [570] ) were included in the study. Median crSO 2 [IQR] values at 15 minutes after birth were 82% [16] in preterm neonates and 83% [12] in term neonates. Median FTOE [IQR] values at 15 minutes after birth were 0.13 [0.15] in preterm neonates and 0.14 [0.14] in term neonates. In preterm neonates, higher LAC and lower pH and BE were associated with lower crSO 2 and higher FTOE. In term neonates, higher HCO 3 was associated with higher FTOE. Conclusion There were significant associations between several acid-base and metabolic parameters and cerebral oxygenation in preterm neonates, while in term neonates only HCO 3 correlated positively with FTOE.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0283278
DOI:
10.1371/journal.pone.0283278.g001
DOI:
10.1371/journal.pone.0283278.g002
DOI:
10.1371/journal.pone.0283278.t001
DOI:
10.1371/journal.pone.0283278.t002
DOI:
10.1371/journal.pone.0283278.s001
DOI:
10.1371/journal.pone.0283278.s002
DOI:
10.1371/journal.pone.0283278.s003
DOI:
10.1371/journal.pone.0283278.s004
DOI:
10.1371/journal.pone.0283278.r001
DOI:
10.1371/journal.pone.0283278.r002
DOI:
10.1371/journal.pone.0283278.r003
DOI:
10.1371/journal.pone.0283278.r004
DOI:
10.1371/journal.pone.0283278.r005
DOI:
10.1371/journal.pone.0283278.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
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