In:
Brain Pathology, Wiley, Vol. 25, No. 4 ( 2015-07), p. 418-428
Abstract:
Diffuse adult high‐grade gliomas ( HGGs ) with necrosis encompass anaplastic oligodendrogliomas ( AOs ) with necrosis (grade III ), glioblastomas ( GBM , grade IV ) and glioblastomas with an oligodendroglial component ( GBMO , grade IV ). Here, we aimed to search for prognostic relevance of histological classification and molecular alterations of these tumors. About 210 patients were included (63 AO , 56 GBM and 91 GBMO ). GBMO group was split into “anaplastic oligoastrocytoma ( AOA ) with necrosis grade IV/GBMO ,” restricted to tumors showing intermingled astrocytic and oligodendroglial component, and “ GBM/GBMO ” based on tumors presenting oligodendroglial foci and features of GBM . Genomic arrays, IDH1 R132H expression analyses and IDH direct sequencing were performed. 1p/19q co‐deletion characterized AO , whereas no IDH1 R132H expression and intact 1p/19q characterized both GBM and GBM/GBMO . AOA with necrosis/ GBMO mainly demonstrated IDH1 R132H expression and intact 1p/19q. Other IDH1 or IDH2 mutations were extremely rare. Both histological and molecular classifications were predictive of progression free survival (PFS) and overall survival (OS) ( P 〈 10 −4 ). Diffuse adult HGGs with necrosis can be split into three histomolecular groups of prognostic relevance: 1p/19q co‐deleted AO , IDH1 R132H ‐ GBM and 1p/19q intact IDH1 R132H + gliomas that might be classified as IDH1 R132H + GBM . Because of histomolecular heterogeneity, we suggest to remove the name GBMO .
Type of Medium:
Online Resource
ISSN:
1015-6305
,
1750-3639
DOI:
10.1111/bpa.2015.25.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2029927-8
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