In:
Acta Anaesthesiologica Scandinavica, Wiley, Vol. 56, No. 2 ( 2012-02), p. 217-223
Abstract:
This is a study comparing two short‐acting local anesthetics lidocaine and 2‐chloroprocaine in combination with fentanyl, to provide selective spinal anesthesia for outpatient transurethral resection of the prostate ( TURP ). Methods In this prospective, randomized double‐blind study, selective spinal anesthesia was performed in 40 American Society of Anesthesiologists I‐III outpatients undergoing TURP using either 40 mg of chloroprocaine mixed with 12.5 μg of fentanyl ( n = 20) or 35 mg of lidocaine mixed with 12.5 μg of fentanyl ( n = 20). The primary outcome was duration of spinal block. Secondary outcomes were time to reach T 10 (onset), time to maximal level, duration above T 10 and lidocaine 3, maximal level of block, and adverse effects. Results The median (minimum, maximum) onset time was 4 (1, 16) and 3 (2, 10) min for chloroprocaine and lidocaine, respectively. Time to maximal level was 20 (17, 29) and 22 (16, 26) min for chloroprocaine and lidocaine, respectively. Mean maximal level was T 7‐ T 8 for both agents. Duration of block above T 10 was 54 (28, 88) and 63 (31, 87) min for chloroprocaine and lidocaine, respectively. Duration of block above lidocaine 3 was 93 (56, 218) and 98 (58, 151) min for chloroprocaine and lidocaine, respectively. There was no statistical difference between the two groups with respect to these clinical end points. Four patients in the lidocaine group developed transient neurological symptoms. One patient in the chloroprocaine group developed a cauda equina‐like syndrome but recovered fully after several weeks. Conclusions Selective spinal anesthesia with chloroprocaine and lidocaine for TURP yielded comparable results for clinical characteristics. Further research on transient neurological symptom and cauda equina risk with chloroprocaine is warranted.
Type of Medium:
Online Resource
ISSN:
0001-5172
,
1399-6576
DOI:
10.1111/aas.2012.56.issue-2
DOI:
10.1111/j.1399-6576.2011.02599.x
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2004319-3
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