In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 25, No. 18_suppl ( 2007-06-20), p. 14045-14045
Abstract:
14045 Background: Penile carcinoma is highly fatal when associated with bulky regional or distant metastases, despite chemotherapy and surgery. Epidermal growth factor receptor (EGFR) is a potential target for systemic therapy, but little is known about its expression or significance in penile carcinoma. Methods: The results of EGFR immunohistochemistry in cases of metastatic squamous cell carcinoma of the penis performed in our Department of Pathology over a 2-year period were reviewed retrospectively. The antibody used in the assay was Zymed clone 31G7. To assess the biological significance of EGFR expression, we reviewed the charts of these patients for EGFR-targeted therapies and outcomes. Results: Thirteen cases were assayed for EGFR expression. The tissue was from a lymph node metastasis in 5 patients, inguinal or scrotal skin metastasis in 2 patients, and the primary tumor in six patients. Tumor cells in all cases were positive for EGFR, and 9 were scored as 3+ or strongly positive. The percentage of cells positive for EGFR was 〉 90% in six cases, 40–50% in one case, and not specified in six cases. All of the patients received one or more EGFR-targeted therapies including erlotinib (one patient), cetuximab (three patients), or cetuximab combined with one or more cytotoxic agents (nine patients). Six patients received a second or third EGFR-targeted therapy. Grade 3 or 4 adverse events were limited to cellulitis, thrombocytopenia, and tumor hemorrhage (one patient each). Two patients had disease progression during initial treatment with paclitaxel, ifosfamide, and cisplatin (TIP), then had partial responses to TIP plus cetuximab. Two patients had partial responses to cetuximab and cisplatin, also after having disease progression while receiving TIP. A patient with visceral metastases who had extensive prior chemotherapy received cetuximab and cisplatin as salvage treatment and experienced objective tumor regression lasting 3 months. Conclusions: High levels of EGFR expression are common in metastatic penile carcinoma. Five of 13 patients showed evidence of response to cetuximab in combination with cisplatin or TIP. These results indicate that EGFR plays a clinically important role in metastatic penile carcinoma and is a promising target for therapy. No significant financial relationships to disclose.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2007.25.18_suppl.14045
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2007
detail.hit.zdb_id:
2005181-5
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