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Cryoelectron Tomographic Analysis of an HIV-neutralizing Protein and Its Complex with Native Viral gp120

Bennett, Adam ; Liu, Jun ; Van Ryk, Donald ; [et al.]

Elsevier BV ; 2007

In: Journal of Biological Chemistry Vol. 282, No. 38 ( 2007-09), p. 27754-27759

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 282, No. 38 ( 2007-09), p. 27754-27759

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M702025200

Language: English

Publisher: Elsevier BV

Publication Date: 2007

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding

Basmaciogullari, Stéphane ; Babcock, Gregory J. ; Van Ryk, Donald ; [et al.]

American Society for Microbiology ; 2002

In: Journal of Virology Vol. 76, No. 21 ( 2002-11), p. 10791-10800

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In: Journal of Virology, American Society for Microbiology, Vol. 76, No. 21 ( 2002-11), p. 10791-10800

Abstract: CD4 and the chemokine receptors, CXCR4 and CCR5, serve as receptors for human immunodeficiency virus type 1 (HIV-1). Binding of the HIV-1 gp120 envelope glycoprotein to the chemokine receptors normally requires prior interaction with CD4. Mapping the determinants on gp120 for the low-affinity interaction with CXCR4 has been difficult due to the nonspecific binding of this viral glycoprotein to cell surfaces. Here we examine the binding of a panel of gp120 mutants to paramagnetic proteoliposomes displaying CXCR4 on their surfaces. We show that the gp120 β19 strand and third variable (V3) loop contain residues important for CXCR4 interaction. Basic residues from both elements, as well as a conserved hydrophobic residue at the V3 tip, contribute to CXCR4 binding. Removal of the gp120 V1/V2 variable loops allows the envelope glycoprotein to bind CXCR4 in a CD4-independent manner. These results indicate that although some variable gp120 residues contribute to the specific binding to CCR5 or CXCR4, gp120 elements common to CXCR4- or CCR5-using strains are involved in the interaction with both coreceptors.

Type of Medium: Online Resource

ISSN: 0022-538X , 1098-5514

URL: Article

DOI: 10.1128/JVI.76.21.10791-10800.2002

Language: English

Publisher: American Society for Microbiology

Publication Date: 2002

detail.hit.zdb_id: 1495529-5

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Sustained virologic control in SIV + macaques after antiretroviral and α 4 β 7 antibody therapy

Byrareddy, Siddappa N. ; Arthos, James ; Cicala, Claudia ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2016

In: Science Vol. 354, No. 6309 ( 2016-10-14), p. 197-202

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In: Science, American Association for the Advancement of Science (AAAS), Vol. 354, No. 6309 ( 2016-10-14), p. 197-202

Abstract: Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α 4 β 7 integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4 + T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.

Type of Medium: Online Resource

ISSN: 0036-8075 , 1095-9203

URL: Article

DOI: 10.1126/science.aag1276

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2016

detail.hit.zdb_id: 128410-1

detail.hit.zdb_id: 2066996-3

detail.hit.zdb_id: 2060783-0

SSG: 11

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Enhanced Immunogenicity of gp120 Protein When Combined with Recombinant DNA Priming To Generate Antibodies That Neutralize the JR-FL Primary Isolate of Human Immunodeficiency Virus Type 1

Wang, Shixia ; Arthos, James ; Lawrence, John M. ; [et al.]

American Society for Microbiology ; 2005

In: Journal of Virology Vol. 79, No. 12 ( 2005-06-15), p. 7933-7937

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In: Journal of Virology, American Society for Microbiology, Vol. 79, No. 12 ( 2005-06-15), p. 7933-7937

Abstract: Strategies are needed for human immunodeficiency virus type 1 vaccine development that improves the neutralizing antibody response against primary isolates of the virus. Here we examined recombinant DNA priming followed by subunit protein boosting as a strategy to generate neutralizing antibodies. Both plasmid-based and recombinant protein envelope (Env) glycoprotein immunogens were derived from a primary viral isolate, JR-FL. Serum from rabbits immunized with either gp120 or gp140 DNA vaccines delivered by gene gun inoculation followed by recombinant gp120 protein boosting was capable of neutralizing JR-FL. Neither the DNA vaccines alone nor the gp120 protein alone generated a detectable neutralizing antibody response against this virus. Neutralizing antibody responses using gp120 DNA and gp140 DNA for priming were similar. The results suggest that Env DNA priming followed by gp120 protein boosting provides an advantage over either approach alone for generating a detectable neutralizing antibody response against primary isolates that are not easily neutralized.

Type of Medium: Online Resource

ISSN: 0022-538X , 1098-5514

URL: Article

DOI: 10.1128/JVI.79.12.7933-7937.2005

Language: English

Publisher: American Society for Microbiology

Publication Date: 2005

detail.hit.zdb_id: 1495529-5

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Genetic probes of ribosomal RNA function

O'Connor, Michael ; Brunelli, Carleen A. ; Firpo, Matthew A. ; [et al.]

Canadian Science Publishing ; 1995

In: Biochemistry and Cell Biology Vol. 73, No. 11-12 ( 1995-12-01), p. 859-868

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In: Biochemistry and Cell Biology, Canadian Science Publishing, Vol. 73, No. 11-12 ( 1995-12-01), p. 859-868

Abstract: We have used a genetic approach to uncover the functional roles of rRNA in protein synthesis. Mutations were constructed in a cloned rrn operon by site-directed mutagenesis or isolated by genetic selections following random mutagenesis. We have identified mutations that affect each step in the process of translation. The data are consistent with the results of biochemical and phylogenetic analyses but, in addition, have provided novel information on regions of rRNA not previously investigated.Key words: decoding, peptidyltransferase, streptomycin, paromomycin, suppression, 4.5S RNA.

Type of Medium: Online Resource

ISSN: 0829-8211 , 1208-6002

URL: Article

DOI: 10.1139/o95-093

Language: English

Publisher: Canadian Science Publishing

Publication Date: 1995

SSG: 12

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Activity changes of three nucleolytic enzymes during the life cycle of Saccharomyces cerevisiae

Van Ryk, Donald I. ; von Tigerstrom, Richard G.

Canadian Science Publishing ; 1985

In: Canadian Journal of Microbiology Vol. 31, No. 12 ( 1985-12-01), p. 1095-1102

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In: Canadian Journal of Microbiology, Canadian Science Publishing, Vol. 31, No. 12 ( 1985-12-01), p. 1095-1102

Abstract: Conditions were established for the assay of three nucleolytic enzymes: a Mg 2+ -independent endoribonuclease, a Mg 2+ -dependent endonuclease, and a Mg 2+ -dependent 5′-exonuclease in Saccharomyces cerevisiae cell extracts. The changes in the activities of these enzymes were determined throughout the life cycle of the organism. As the cells progressed from the exponential to the stationary growth phase, the specific activities of the Mg 2+ -independent endoribonuclease and of the Mg 2+ -dependent 5′-exonuclease increased, whereas the Mg 2+ -dependent endonuclease decreased. During sporulation the Mg 2+ -independent endoribonuclease and the Mg 2+ -dependent 5′-exonuclease increased several-fold over the first 10 h, but, since a similar increase was seen in nonsporulating control cells, the increases did not appear to be related to sporulation. However, the specific activity of the Mg 2+ -dependent endonuclease showed a sporulation-related increase during the first 3 h of sporulation, with a subsequent decline to very low levels. The specific activity of this enzyme increased again during germination to the levels seen in exponential phase cells. The Mg 2+ -independent endoribonuclease and the Mg 2+ -dependent 5′-exonuclease showed little change during germination of the ascospores. The high specific activity of the Mg 2+ -independent endoribonuclease during periods of nutrient deprivation is in agreement with the proposed role for this enzyme in the degradation of rRNA under these conditions.

Type of Medium: Online Resource

ISSN: 0008-4166 , 1480-3275

URL: Article

DOI: 10.1139/m85-207

RVK:

WA 15000

Language: English

Publisher: Canadian Science Publishing

Publication Date: 1985

detail.hit.zdb_id: 280534-0

detail.hit.zdb_id: 1481972-7

SSG: 12

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Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy

Gupta, Neil ; Arthos, James ; Khazanie, Prateeti ; [et al.]

Elsevier BV ; 2005

In: Virology Vol. 332, No. 2 ( 2005-02), p. 491-497

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In: Virology, Elsevier BV, Vol. 332, No. 2 ( 2005-02), p. 491-497

Type of Medium: Online Resource

ISSN: 0042-6822

URL: Article

DOI: 10.1016/j.virol.2004.12.018

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2005

detail.hit.zdb_id: 1471925-3

SSG: 12

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Design clues from functional constraints and broadly neutralizing antibodies

Zhou, Tongqing ; Xu, Ling ; Dey, Barna ; [et al.]

Springer Science and Business Media LLC ; 2006

In: Retrovirology Vol. 3, No. S1 ( 2006-12)

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In: Retrovirology, Springer Science and Business Media LLC, Vol. 3, No. S1 ( 2006-12)

Type of Medium: Online Resource

ISSN: 1742-4690

URL: Article

DOI: 10.1186/1742-4690-3-S1-S22

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2006

detail.hit.zdb_id: 2142602-8

SSG: 12

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MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells

Vimonpatranon, Sinmanus ; Goes, Livia R. ; Chan, Amanda ; [et al.]

Public Library of Science (PLoS) ; 2023

In: PLOS Pathogens Vol. 19, No. 3 ( 2023-3-10), p. e1011209-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 3 ( 2023-3-10), p. e1011209-

Abstract: CD4 + tissue resident memory T cells (T RM s) are implicated in the formation of persistent HIV reservoirs that are established during the very early stages of infection. The tissue-specific factors that direct T cells to establish tissue residency are not well defined, nor are the factors that establish viral latency. We report that costimulation via MAdCAM-1 and retinoic acid (RA), two constituents of gut tissues, together with TGF-β, promote the differentiation of CD4 + T cells into a distinct subset α 4 β 7 + CD69 + CD103 + T RM -like cells. Among the costimulatory ligands we evaluated, MAdCAM-1 was unique in its capacity to upregulate both CCR5 and CCR9. MAdCAM-1 costimulation rendered cells susceptible to HIV infection. Differentiation of T RM -like cells was reduced by MAdCAM-1 antagonists developed to treat inflammatory bowel diseases. These finding provide a framework to better understand the contribution of CD4 + T RM s to persistent viral reservoirs and HIV pathogenesis.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1011209

DOI: 10.1371/journal.ppat.1011209.g001

DOI: 10.1371/journal.ppat.1011209.g002

DOI: 10.1371/journal.ppat.1011209.g003

DOI: 10.1371/journal.ppat.1011209.g004

DOI: 10.1371/journal.ppat.1011209.g005

DOI: 10.1371/journal.ppat.1011209.g006

DOI: 10.1371/journal.ppat.1011209.g007

DOI: 10.1371/journal.ppat.1011209.s001

DOI: 10.1371/journal.ppat.1011209.s002

DOI: 10.1371/journal.ppat.1011209.s003

DOI: 10.1371/journal.ppat.1011209.s004

DOI: 10.1371/journal.ppat.1011209.s005

DOI: 10.1371/journal.ppat.1011209.s006

DOI: 10.1371/journal.ppat.1011209.s007

DOI: 10.1371/journal.ppat.1011209.s008

DOI: 10.1371/journal.ppat.1011209.s009

DOI: 10.1371/journal.ppat.1011209.s010

DOI: 10.1371/journal.ppat.1011209.s011

DOI: 10.1371/journal.ppat.1011209.s012

DOI: 10.1371/journal.ppat.1011209.s013

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2023

detail.hit.zdb_id: 2205412-1

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Tyrosine-sulfated V2 peptides inhibit HIV-1 infection via coreceptor mimicry

Cimbro, Raffaello ; Peterson, Francis C. ; Liu, Qingbo ; [et al.]

Elsevier BV ; 2016

In: eBioMedicine Vol. 10 ( 2016-08), p. 45-54

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In: eBioMedicine, Elsevier BV, Vol. 10 ( 2016-08), p. 45-54

Type of Medium: Online Resource

ISSN: 2352-3964

URL: Article

DOI: 10.1016/j.ebiom.2016.06.037

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2799017-5

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