In:
Muscle & Nerve, Wiley, Vol. 43, No. 2 ( 2011-02), p. 212-222
Abstract:
If myonuclear loss initiates muscle wasting, it should precede the loss of muscle mass. As aging affects muscle plasticity, the time‐course of muscle atrophy during disuse may differ between young and old animals. To investigate this, gastrocnemius muscles of 5‐ and 25‐month‐old rats were exposed to 1, 2, or 4 weeks of denervation, whereas the contralateral gastrocnemius muscles served as controls. Muscle fibers of each type responded similarly to 4 weeks of denervation. For both ages most of the atrophy (36%; P 〈 0.001) occurred in the first 2 weeks. In young‐adult muscles, the myonuclear number remained constant, but in old muscles it decreased to below control level after 4 weeks of denervation ( P 〈 0.05). Despite this differential response, myonuclear domain size decreased similarly at both ages ( P 〈 0.001). In both young‐adult and old rats, denervation‐induced atrophy was not preceded by a loss of myonuclei. Muscle Nerve 43: 212–222, 2011
Type of Medium:
Online Resource
ISSN:
0148-639X
,
1097-4598
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1476641-3
SSG:
12
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