In:
PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 1 ( 2023-1-4), p. e0266985-
Abstract:
In young adults (18 to 49 years old), investigation of the acute respiratory distress syndrome (ARDS) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been limited. We evaluated the risk factors and outcomes of ARDS following infection with SARS-CoV-2 in a young adult population. Methods A retrospective cohort study was conducted between January 1st, 2020 and February 28th, 2021 using patient-level electronic health records (EHR), across 241 United States hospitals and 43 European hospitals participating in the Consortium for Clinical Characterization of COVID-19 by EHR (4CE). To identify the risk factors associated with ARDS, we compared young patients with and without ARDS through a federated analysis. We further compared the outcomes between young and old patients with ARDS. Results Among the 75,377 hospitalized patients with positive SARS-CoV-2 PCR, 1001 young adults presented with ARDS (7.8% of young hospitalized adults). Their mortality rate at 90 days was 16.2% and they presented with a similar complication rate for infection than older adults with ARDS. Peptic ulcer disease, paralysis, obesity, congestive heart failure, valvular disease, diabetes, chronic pulmonary disease and liver disease were associated with a higher risk of ARDS. We described a high prevalence of obesity (53%), hypertension (38%- although not significantly associated with ARDS), and diabetes (32%). Conclusion Trough an innovative method, a large international cohort study of young adults developing ARDS after SARS-CoV-2 infection has been gather. It demonstrated the poor outcomes of this population and associated risk factor.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0266985
DOI:
10.1371/journal.pone.0266985.g001
DOI:
10.1371/journal.pone.0266985.g002
DOI:
10.1371/journal.pone.0266985.t001
DOI:
10.1371/journal.pone.0266985.t002
DOI:
10.1371/journal.pone.0266985.t003
DOI:
10.1371/journal.pone.0266985.s001
DOI:
10.1371/journal.pone.0266985.s002
DOI:
10.1371/journal.pone.0266985.s003
DOI:
10.1371/journal.pone.0266985.s004
DOI:
10.1371/journal.pone.0266985.s005
DOI:
10.1371/journal.pone.0266985.s006
DOI:
10.1371/journal.pone.0266985.s007
DOI:
10.1371/journal.pone.0266985.s008
DOI:
10.1371/journal.pone.0266985.r001
DOI:
10.1371/journal.pone.0266985.r002
DOI:
10.1371/journal.pone.0266985.r003
DOI:
10.1371/journal.pone.0266985.r004
DOI:
10.1371/journal.pone.0266985.r005
DOI:
10.1371/journal.pone.0266985.r006
DOI:
10.1371/journal.pone.0266985.r007
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2267670-3
Bookmarklink