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Salmonella Typhimurium uses the Cpx stress response to detect N -chlorotaurine and promote the repair of oxidized proteins

Andrieu, Camille ; Loiseau, Laurent ; Vergnes, Alexandra ; [et al.]

Proceedings of the National Academy of Sciences ; 2023

In: Proceedings of the National Academy of Sciences Vol. 120, No. 14 ( 2023-04-04)

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In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 120, No. 14 ( 2023-04-04)

Abstract: The cell envelope of gram-negative bacteria constitutes the first protective barrier between a cell and its environment. During host infection, the bacterial envelope is subjected to several stresses, including those induced by reactive oxygen species (ROS) and reactive chlorine species (RCS) produced by immune cells. Among RCS, N- chlorotaurine ( N- ChT), which results from the reaction between hypochlorous acid and taurine, is a powerful and less diffusible oxidant. Here, using a genetic approach, we demonstrate that Salmonella Typhimurium uses the CpxRA two-component system to detect N -ChT oxidative stress. Moreover, we show that periplasmic methionine sulfoxide reductase (MsrP) is part of the Cpx regulon. Our findings demonstrate that MsrP is required to cope with N -ChT stress by repairing N -ChT-oxidized proteins in the bacterial envelope. By characterizing the molecular signal that induces Cpx when S. Typhimurium is exposed to N -ChT, we show that N -ChT triggers Cpx in an NlpE-dependent manner. Thus, our work establishes a direct link between N -ChT oxidative stress and the envelope stress response.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.2215997120

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2023

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

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Alchimies futures : compte rendu de l'expérience ESYOP

Compain, Philippe ; Desvergnes, Valérie ; Ollivier, Cyril ; [et al.]

Elsevier BV ; 2006

In: Comptes Rendus Chimie Vol. 9, No. 1 ( 2006-1), p. 127-140

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In: Comptes Rendus Chimie, Elsevier BV, Vol. 9, No. 1 ( 2006-1), p. 127-140

Type of Medium: Online Resource

ISSN: 1631-0748

URL: Article

DOI: 10.1016/j.crci.2005.09.004

Language: French

Publisher: Elsevier BV

Publication Date: 2006

detail.hit.zdb_id: 2079102-1

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HprSR Is a Reactive Chlorine Species-Sensing, Two-Component System in Escherichia coli

El Hajj, Sara ; Henry, Camille ; Andrieu, Camille ; [et al.]

American Society for Microbiology ; 2022

In: Journal of Bacteriology Vol. 204, No. 2 ( 2022-02-15)

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In: Journal of Bacteriology, American Society for Microbiology, Vol. 204, No. 2 ( 2022-02-15)

Abstract: Two-component systems (TCS) are signaling pathways that allow bacterial cells to sense, respond to, and adapt to fluctuating environments. Among the classical TCS of Escherichia coli , HprSR has recently been shown to be involved in the regulation of msrPQ , which encodes the periplasmic methionine sulfoxide reductase system. In this study, we demonstrated that hypochlorous acid (HOCl) induces the expression of msrPQ in an HprSR-dependent manner, whereas H 2 O 2 , NO, and paraquat (a superoxide generator) do not. Therefore, HprS appears to be an HOCl-sensing histidine kinase. Using a directed mutagenesis approach, we showed that Met residues located in the periplasmic loop of HprS are important for its activity: we provide evidence that as HOCl preferentially oxidizes Met residues, HprS could be activated via the reversible oxidation of its methionine residues, meaning that MsrPQ plays a role in switching HprSR off. We propose that the activation of HprS by HOCl could occur through a Met redox switch. HprSR appears to be the first characterized TCS able to detect reactive chlorine species (RCS) in E. coli . This study represents an important step toward understanding the mechanisms of RCS resistance in prokaryotes. IMPORTANCE Understanding how bacteria respond to oxidative stress at the molecular level is crucial in the fight against pathogens. HOCl is one of the most potent industrial and physiological microbicidal oxidants. Therefore, bacteria have developed counterstrategies to survive HOCl-induced stress. Over the last decade, important insights into these bacterial protection factors have been obtained. Our work establishes HprSR as a reactive chlorine species-sensing, two-component system in Escherichia coli MG1655, which regulates the expression of msrPQ , two genes encoding, a repair system for HOCl-oxidized proteins. Moreover, we provide evidence suggesting that HOCl could activate HprS through a methionine redox switch.

Type of Medium: Online Resource

ISSN: 0021-9193 , 1098-5530

URL: Article

DOI: 10.1128/jb.00449-21

Language: English

Publisher: American Society for Microbiology

Publication Date: 2022

detail.hit.zdb_id: 1481988-0

SSG: 12

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Looking forward: a glance into the future of organic chemistry

Compain, Philippe ; Desvergnes, Valérie ; Ollivier, Cyril ; [et al.]

Royal Society of Chemistry (RSC) ; 2006

In: New J. Chem. Vol. 30, No. 6 ( 2006), p. 823-831

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In: New J. Chem., Royal Society of Chemistry (RSC), Vol. 30, No. 6 ( 2006), p. 823-831

Type of Medium: Online Resource

ISSN: 1144-0546 , 1369-9261

URL: Article

DOI: 10.1039/B601837H

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2006

detail.hit.zdb_id: 1472933-7

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The iron-sulfur cluster sensor IscR is a negative regulator of Spi1 type III secretion system in Salmonella enterica : The iron-sulfur cluster sensor IscR is a negative regulator of Spi1 type III secretion system in Salmonella enterica

Vergnes, Alexandra ; Viala, Julie P.M. ; Ouadah-Tsabet, Rabah ; [et al.]

Hindawi Limited ; 2017

In: Cellular Microbiology Vol. 19, No. 4 ( 2017-04), p. e12680-

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In: Cellular Microbiology, Hindawi Limited, Vol. 19, No. 4 ( 2017-04), p. e12680-

Type of Medium: Online Resource

ISSN: 1462-5814

URL: Article

DOI: 10.1111/cmi.12680

Language: English

Publisher: Hindawi Limited

Publication Date: 2017

detail.hit.zdb_id: 2019990-9

SSG: 12

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Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons

Cepeda, Carlos ; Vergnes, Laurent ; Carpo, Nicholas ; [et al.]

MDPI AG ; 2019

In: Applied Sciences Vol. 9, No. 19 ( 2019-09-27), p. 4042-

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In: Applied Sciences, MDPI AG, Vol. 9, No. 19 ( 2019-09-27), p. 4042-

Abstract: Here we demonstrate that human neural stem cells (NSCs) proliferate while in space and they express specific NSC markers after being in space. NSCs displayed both higher oxygen consumption and glycolysis than ground controls. These cells also kept their ability to become young neurons. Electrophysiological recordings of space NSC-derived neurons showed immature cell membrane properties characterized by small capacitance and very high input resistance. Current injections elicited only an incipient action potential. No spontaneous synaptic events could be detected, suggesting their immature status even though most recorded cells displayed complex morphology and numerous cell processes. Ascertaining the origin of the NSCs’ increased energy requirement is of the essence in order to design effective measures to minimize health risks associated with long-duration human spaceflight missions.

Type of Medium: Online Resource

ISSN: 2076-3417

URL: Article

DOI: 10.3390/app9194042

Language: English

Publisher: MDPI AG

Publication Date: 2019

detail.hit.zdb_id: 2704225-X

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Characterisation of the periplasmic methionine sulfoxide reductase (MsrP) from Salmonella Typhimurium

Andrieu, Camille ; Vergnes, Alexandra ; Loiseau, Laurent ; [et al.]

Elsevier BV ; 2020

In: Free Radical Biology and Medicine Vol. 160 ( 2020-11), p. 506-512

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In: Free Radical Biology and Medicine, Elsevier BV, Vol. 160 ( 2020-11), p. 506-512

Type of Medium: Online Resource

ISSN: 0891-5849

URL: Article

DOI: 10.1016/j.freeradbiomed.2020.06.031

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 1483653-1

SSG: 12

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Human apolipoprotein A‐IV reduces gastric acid secretion and diminishes ulcer formation in transgenic mice

Vergnes, Laurent ; Baroukh, Nadine ; Léhy, Thérèse ; [et al.]

Wiley ; 1999

In: FEBS Letters Vol. 460, No. 1 ( 1999-10-22), p. 178-181

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In: FEBS Letters, Wiley, Vol. 460, No. 1 ( 1999-10-22), p. 178-181

Abstract: We have investigated the involvement of human apolipoprotein A‐IV (apoA‐IV) in gastric acid secretion and ulcer formation in recently generated apoA‐IV transgenic mice. Compared to control littermates, transgenic animals showed a gastric acid secretion decreased by 43–77% whereas only slight variations were observed in the different cell population densities within the gastric mucosa. In addition, no variation in gastrin levels was observed. Transgenics were protected against indomethacin‐induced ulcer formation, with lesions diminishing by 45 to 64% compared to controls. These results indicate that endogenous apoA‐IV expression can regulate gastric acid secretion and ulcer development.

Type of Medium: Online Resource

ISSN: 0014-5793 , 1873-3468

URL: Article

DOI: 10.1016/S0014-5793(99)01332-0

RVK:

WA 15000

Language: English

Publisher: Wiley

Publication Date: 1999

detail.hit.zdb_id: 1460391-3

SSG: 12

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Periplasmic oxidized-protein repair during copper stress in E. coli: A focus on the metallochaperone CusF

Vergnes, Alexandra ; Henry, Camille ; Grassini, Gaia ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS Genetics Vol. 18, No. 7 ( 2022-7-11), p. e1010180-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 18, No. 7 ( 2022-7-11), p. e1010180-

Abstract: Methionine residues are particularly sensitive to oxidation by reactive oxygen or chlorine species (ROS/RCS), leading to the appearance of methionine sulfoxide in proteins. This post-translational oxidation can be reversed by omnipresent protein repair pathways involving methionine sulfoxide reductases (Msr). In the periplasm of Escherichia coli , the enzymatic system MsrPQ, whose expression is triggered by the RCS, controls the redox status of methionine residues. Here we report that MsrPQ synthesis is also induced by copper stress via the CusSR two-component system, and that MsrPQ plays a role in copper homeostasis by maintaining the activity of the copper efflux pump, CusCFBA. Genetic and biochemical evidence suggest the metallochaperone CusF is the substrate of MsrPQ and our study reveals that CusF methionines are redox sensitive and can be restored by MsrPQ. Thus, the evolution of a CusSR-dependent synthesis of MsrPQ allows conservation of copper homeostasis under aerobic conditions by maintenance of the reduced state of Met residues in copper-trafficking proteins.

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1010180

DOI: 10.1371/journal.pgen.1010180.g001

DOI: 10.1371/journal.pgen.1010180.g002

DOI: 10.1371/journal.pgen.1010180.g003

DOI: 10.1371/journal.pgen.1010180.g004

DOI: 10.1371/journal.pgen.1010180.g005

DOI: 10.1371/journal.pgen.1010180.g006

DOI: 10.1371/journal.pgen.1010180.t001

DOI: 10.1371/journal.pgen.1010180.t002

DOI: 10.1371/journal.pgen.1010180.t003

DOI: 10.1371/journal.pgen.1010180.s001

DOI: 10.1371/journal.pgen.1010180.s002

DOI: 10.1371/journal.pgen.1010180.r001

DOI: 10.1371/journal.pgen.1010180.r002

DOI: 10.1371/journal.pgen.1010180.r003

DOI: 10.1371/journal.pgen.1010180.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2186725-2

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The apolipoprotein AICIII-AIV gene cluster: sequence of the ApoCIII-ApoAIV intergenic region

Omori, Kenji ; Vergnes, Laurent ; Zakin, Mario M. ; [et al.]

Elsevier BV ; 1995

In: Gene Vol. 159, No. 2 ( 1995-1), p. 231-234

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In: Gene, Elsevier BV, Vol. 159, No. 2 ( 1995-1), p. 231-234

Type of Medium: Online Resource

ISSN: 0378-1119

URL: Article

DOI: 10.1016/0378-1119(95)00063-C

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 1995

detail.hit.zdb_id: 1491012-3

SSG: 12

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