In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2022-12-30), p. e0278839-
Abstract:
Publication bias may lead to a misestimation in the association between pharmacogenetic biomarkers (PGx) and antiseizure drug’s adverse effects (AEs). We aimed to assess its prevalence in this field. We searched for systematic reviews assessing PGx of antiseizure drug’s AEs. For each unique association between a PGx, a drug and its AE, we used the available odds ratio (ORs) to generate corresponding funnel plots. We estimated the prevalence of publication bias using visual inspections and asymmetry tests. We explored the impact of publication bias using ORs adjusted for potential publication bias. Twenty-two associations were available. Our visual analysis suggested a publication bias in five out twenty-two funnel plots (23% [95%CI: 8; 45] ). The Egger’s test showed a significant publication bias in one (HLA-B*15:02 and phenytoin-induced Stevens-Johnson syndrome or toxic epidermal necrolysis, p = 0.03) out of nine (11% [95%CI: 0; 48]) and the Begg’s test in one (HLA-B*15:02 and carbamazepine-induced serious cutaneous reactions, p = 0.02) out of ten (10% [95%CI: 0; 45] ) assessable funnel plots. Adjusting for publication bias may reduce by half the ORs of the pharmacogenetics associations. Publication bias in the pharmacogenetic of antiseizure drug’s AEs is not uncommon and may affect the estimation of the effect of such biomarkers. When conducting pharmacogenetic studies, it is critical to publish also the negative one.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0278839
DOI:
10.1371/journal.pone.0278839.g001
DOI:
10.1371/journal.pone.0278839.g002
DOI:
10.1371/journal.pone.0278839.g003
DOI:
10.1371/journal.pone.0278839.t001
DOI:
10.1371/journal.pone.0278839.t002
DOI:
10.1371/journal.pone.0278839.t003
DOI:
10.1371/journal.pone.0278839.s001
DOI:
10.1371/journal.pone.0278839.s002
DOI:
10.1371/journal.pone.0278839.s003
DOI:
10.1371/journal.pone.0278839.s004
DOI:
10.1371/journal.pone.0278839.r001
DOI:
10.1371/journal.pone.0278839.r002
DOI:
10.1371/journal.pone.0278839.r003
DOI:
10.1371/journal.pone.0278839.r004
DOI:
10.1371/journal.pone.0278839.r005
DOI:
10.1371/journal.pone.0278839.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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