In:
European Journal of Case Reports in Internal Medicine, SMC Media, ( 2022-12-02)
Abstract:
Takayasu arteritis is a systemic vasculitis of the large vessels and mainly affects Japanese and Southeast Asian women in the second and third decades of life. Inflammatory infiltrate affects the full thickness of the vessel wall, inducing progressive lumen stenosis and occlusion. The main biomarkers of disease activity are the ESR, CRP and serum levels of circulating cytokines. This case report describes the clinical history of a young woman with Takayasu disease with high serum levels of IgA at onset. IgA remained elevated with persistence of disease activity, and normalized only when the patient was treated with an anti-TNF agent (infliximab), which also induced a clinical response in the vasculitis. IgA levels, together with other inflammatory parameters, may be considered a biomarker of disease activity.
Type of Medium:
Online Resource
ISSN:
2284-2594
DOI:
10.12890/2022_003664
Language:
English
Publisher:
SMC Media
Publication Date:
2022
detail.hit.zdb_id:
3016175-7
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