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  • 1
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    Breast reconstruction following amputation for cancer
    National Library of Serbia ; 2009
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 66, No. 6 ( 2009), p. 427-433
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 66, No. 6 ( 2009), p. 427-433
    Abstract: Uvod/Cilj. Rekonstrukcija dojke danas je siroko prihvacena metoda u lecenju karcinoma dojke nakon modifikovane radikalne mastektomije. Metode rekonstrukcije prati prihvatljiv broj komplikacija, ali rekonstrukcija dojke pozitivno utice na kvalitet zivota bolesnica. Cilj ovog rada bio je da ukaze na nasa iskustva u rekonstrukciji dojke. Metode. Prikazano je cetvorogodisnje iskustvo sa 84 bolesnice kod kojih je radjena rekonstrukcija dojke posle modifikovane radikalne mastektomije. Rezultati. Najcesce je rekonstrukcija radjena implantatima i to kod 44 (52,3%) bolesnice, a od toga primarna rekonstrukcija kod 31 (70,4%) bolesnice, a sekundarna kod 13 bolesnica (29,5%). Latissimus dorsi rezanj (LDR) i implantat korisceni su kod 32 (38%) bolesnice, s tim sto je primarna rekonstrukcija radjena kod 24 (75%), a sekundarna kod 8 (25%) bolesnica. Transverzalni rectus abdominis miokutani rezanj (TRAM) retko je koriscen, samo kod osam (9,5%) bolesnica i to samo za sekundarnu rekonstrukciju dojke. U postoperativnom toku registrovane su rane komplikacije, poput hematoma, seroma, infekcije i parcijalane nekroze reznja kod 10 (11,9%) bolesnica. Kasne komplikacije, poput odbacivanja implantata, hipertroficnih oziljaka i stvaranje hernija na mestu podizanja reznja, registrovane su kod 10 (11,9%) bolesnica. Gubitak implantata registrovan je kod pet (5,9%) bolesnica. Sve komplikacije uspesno su resene. Cetrdeset devet (59%) bolesnica ocenilo je uspeh rekonstrukcije odlicnim, vrlo dobrim 20 (24%), a dobrim 14 (16,8%). Kod jedne bolesnice registrovana je progresija bolesti 6 meseci nakon primarne rekonstrukcije dojke. Zakljucak. Rekonstrukcija dojke predstavlja prihvatljivu metodu u lecenju karcinoma dojke kod bolesnica kod kojih je indikovana ili je vec uradjena mastektomija. Izbor metode rekonstrukcije zavisi od velicine dojki, zelje bolesnice i iskustva hirurske ekipe. Nasi rezultati daju prednost rekonstrukciji dojke LDR sa implantatom, jer je tehnika rekonstrukcije jednostavna i sigurna, komplikacije relativno retke i lako resive, a rezultati rekonstrukcije odlicni ili vrlo dobri kod svih bolesnica.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP0906427V
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2009
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 2
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    Our experiencies in treatment of squamous cell skin cancer of head and heck
    National Library of Serbia ; 2003
    In:  Acta chirurgica Iugoslavica Vol. 50, No. 4 ( 2003), p. 85-89
    Details
    In: Acta chirurgica Iugoslavica, National Library of Serbia, Vol. 50, No. 4 ( 2003), p. 85-89
    Abstract: Planocelularni karcinom koze je drugi po ucestalosti maligni tumor koze odmah posle bazocelularnog karcinoma. Hirursko lecenje je prva i najefikasnija terapija ovog tumora. Cilj rada je da se prikazu rezultati Hirurske klinike u Nisu u lecenju planocelularnog kacrinoma koze lica i vrata. U desetogodisnjem periodu (1991-2000) operisano je 346 pacijenata sa planocelularnim karcinomom koze lica i rata. Radjene su ekscizije tumora sa marginama klinicki zdravog 5-10 mm, uz primenu radikalnijih operativnih zahvata kod uznapredovalih tumora. U postoperativnom toku verifikovane su komplikcije kod 14 (4,04%) pacijenata. Blagovremeno postavljena dijagnoza i indikacija za opertivno lecenje planocelularnog karcinoma koze lica preduslov je za dobar postoperativni rezultat sa niskom stopom komplikacija.
    Type of Medium: Online Resource
    ISSN: 0354-950X , 2406-0887
    URL: Article
    DOI: 10.2298/ACI0304085K
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2003
    detail.hit.zdb_id: 2586634-5
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  • 3
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    Sentinel node biopsy for skin melanoma
    National Library of Serbia ; 2009
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 66, No. 8 ( 2009), p. 657-662
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 66, No. 8 ( 2009), p. 657-662
    Abstract: Uvod/Cilj. Melanomi koze su jedan od najmalignijih neoplazmi sa sve vecom stopom incidencije. Biopsija limfnog cvora strazara (sentinel biopsija) veoma je vazna za rano otkrivanje metastaza. Cilj istrazivanja bio je da se analizira prvih 40 bolesnika sa melanomom koze debljine 1-4 mm kod kojih je bila indikovana biopsija cvora strazara (BCS). Metode. Analizirane su demografske karakteristike bolesnika, lokalizacija primarnog melanoma kao i histoloski gradus melanoma koze. Vrsena je BCS uz primenu intraoperativne detekcije radiokoloidima i boje metilen plavo. Rezultati. Analizirane su komplikacije BCS i utvrdjena je pojava seroma kod 5% bolesnika. Terapijska disekcija limfnih cvorova (LC) uradjena je kod 10 bolesnika kod kojih je bila pozitivna BCS. Bolesnici su praceni dve godine. Kod pet bolesnika utvrdjeno je da je BCS bila lazno negativna. Kod te grupe bolesnika uradjena je terapijska disekcija LC posle prosecno 11 meseci od biosije. Zakljucak. Primena BCS kod bolesnika sa melanomom korisna je dijagnosticka procedura. Moze se preporuciti kao standardna procedura za bolesnike sa primarnim melanomom debljine 1-4 mm.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP0908657K
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2009
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 4
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    Comparative analysis of autodermal graft and polypropylene mesh use in large incisional hernia defects reconstruction
    National Library of Serbia ; 2013
    In:  Military Medical and Pharmaceutical Journal of Serbia Vol. 70, No. 2 ( 2013), p. 182-188
    Details
    In: Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 70, No. 2 ( 2013), p. 182-188
    Abstract: Uvod. Veliki defekti trbusnog zida kod incizionih kila jos uvek su veliki izazov u plasticno rekonstruktivnoj i abdominalnoj hirurgiji. Za njihove uspesne bestenzione rekonstrukcije, kojim se postizu najbolji rezultati, pored adekvatnih indikacija i hirurske tehnike presudan je i pravilan izbor rekonstruktivnog materijala. U poslednjim decenijama dominirala je primena sintetskih graftova dok su bioloski autodermalni graftovi retko korisceni. Cilj rada bio je da se uporedi efikasnost i bezbednost sintetickih i autodermalnih graftova u rekonstrukcijama velikih defekata trbusnog zida. Metode. Ova prospektivna, randomizirana, komparativna klinicka studija obuhvatila je 40 bolesnika hospitalizovanih i operativno lecenih u periodu od 10 godina primenom bioloskih autodermalnih i sintetskih polipropilenskih graftova. Bolesnici su bili podeljeni u dve brojcano jednake grupe. Formirane grupe bile su slicne u odnosu na osobine defekata i opste stanje bolesnika. Analizirana je hirurska tehnika izvodjenja rekonstrukcija, trajanje operacija, nastanak lakih ranih i teskih, kao i kasnih postoperativnih komplikacija i duzina hospitalizacije. Bolesnici su prospektivno praceni prosecno dve godine. Rezultati. Nije bilo statisticki znacajne razlike u demografskim karakteristikama ispitivanih bolesnika niti velicine defekata. Hirurska tehnika rekonstrukcije primenom autodermalnih graftova bila je slozenija. Duzina operacija u grupi bolesnika operisanih primenom autodermalnih graftova bila je statisticki znacajno veca. Nije bilo statisticki znacajne razlike u ucestalosti lakih, ranih postoperativnih komplikacija u ispitivanim grupama. U grupi sa sintetskim graftovima registrovane su dve teze komplikacije u obliku enterokutane fistule i adhezionog ileusa. Ucestalost kasnih komplikacija u obliku recidiva iznosila je 10% u grupi sa autodermalnim graftom, a 15% u grupi sa sintetskim graftom. Zakljucak. Bestenziona rekonstrukcija autodermalnim graftovima iako bezbedna i efikasna, neopravdano je zapostavljena metoda. Ona se moze primeniti u svim slucajevima gde su sintetski graftovi kontraindikovani (prisustvo infekcije, imunodeficijentni bolesnici, stanje posle radioterapije), u vanrednim situacijama, kao sto su ratovi ili elementarne katastrofe, i u nedostatku finansijskih sredstava, kada se industrijski proizvedeni graftovi ne mogu nabaviti.
    Type of Medium: Online Resource
    ISSN: 0042-8450 , 2406-0720
    URL: Article
    DOI: 10.2298/VSP1302182S
    Language: English
    Publisher: National Library of Serbia
    Publication Date: 2013
    detail.hit.zdb_id: 2169819-3
    SSG: 15,3
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  • 5
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    Characteristics of Upper Urothelial Carcinoma in an Area of Balkan Endemic Nephropathy in South Serbia. A fifty-year Retrospective Study
    SAGE Publications ; 2010
    In:  Tumori Journal Vol. 96, No. 5 ( 2010-09), p. 674-679
    Details
    In: Tumori Journal, SAGE Publications, Vol. 96, No. 5 ( 2010-09), p. 674-679
    Abstract: Upper urinary tract transitional cell carcinoma, a relatively rare tumor, is up to 100 times more frequent in regions with Balkan endemic nephropathy. Characteristics of transitional cell carcinoma in the endemic South Morava Region in Serbia in the previous 50 years were evaluated. Patients We analyzed 477 cases with pathologically confirmed transitional cell carcinoma who underwent surgery from 1957 to 2006: 91 from endemic, 106 from adjacent and 280 from control settlements. Cases in the study came from 10 endemic villages, 46 adjacent villages, 51 control villages and the city of Nis. Results The increase in number of transitional cell carcinoma from 1957 was followed by a peak between 1967 and 1978 (yearly incidence 21.9 per 100,000) and a slow decrease thereafter to 7.4 (1997–2006). In the control settlements, the increase was steady. Reduced kidney function at surgery was found in 58% of patients from endemic and in 20% from control settlements. Age at surgery has significantly increased from 52.3 and 51.5 (1957–1966) to 70.9 and 66.1 (1997–2006) for endemic and control settlements, respectively. The female sex was predominant in endemic and adjacent settlements and the male sex in control settlements. Transitional cell carcinoma from endemic settlements was of a lower grade in the period from 1957–1986, but in the period from 1987–2006 they were predominantly high grade. Low tumor stage (pTa-pT1) predominated in transitional cell carcinoma from the endemic and adjacent but not the control settlements in the period from 1957 to 1986. However, in the last 20 years, upper urinary tract transitional cell carcinoma stage increased, the highest in the period from 1997 to 2006 in all settlements studied. Conservative surgery was advocated for transitional cell carcinoma in Balkan endemic nephropathy areas up to 1996. Transitional cell carcinoma are now more malignant and more advanced than before, and a less aggressive approach is used only for absolute indications. Conclusions An increased number of transitional cell carcinoma in endemic settlements was observed, markedly decreasing in the last decade. An increasing age and a shorter survival were recorded in patients both from Balkan endemic nephropathy and control settlements. Sporadic cases upper urinary tract transitional cell carcinoma in settlements adjacent to endemic settlements were demonstrated. Free full text available at www.tumorionline.it
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089161009600505
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 6
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    Extended orbital exenteration in the treatment of advanced periocular skin cancer with primary reconstruction with a galeacutaneous flap
    Informa UK Limited ; 2009
    In:  Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery Vol. 43, No. 6 ( 2009-01), p. 325-329
    Details
    In: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, Informa UK Limited, Vol. 43, No. 6 ( 2009-01), p. 325-329
    Type of Medium: Online Resource
    ISSN: 0284-4311
    URL: Article
    DOI: 10.1080/02844310903138963
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2009
    detail.hit.zdb_id: 2551921-9
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  • 7
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    Application of Sentinel Lymph Node Biopsy in Cutaneous Basosquamous Carcinoma
    XMLink ; 2011
    In:  Annals of Dermatology Vol. 23, No. Suppl 1 ( 2011), p. S123-
    Details
    In: Annals of Dermatology, XMLink, Vol. 23, No. Suppl 1 ( 2011), p. S123-
    Type of Medium: Online Resource
    ISSN: 1013-9087
    URL: Article
    DOI: 10.5021/ad.2011.23.S1.S123
    Language: English
    Publisher: XMLink
    Publication Date: 2011
    detail.hit.zdb_id: 2554502-4
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  • 8
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    Urothelial Cancer Stem Cells
    Hindawi Limited ; 2010
    In:  The Scientific World JOURNAL Vol. 10 ( 2010), p. 1400-1415
    Details
    In: The Scientific World JOURNAL, Hindawi Limited, Vol. 10 ( 2010), p. 1400-1415
    Abstract: There is mounting evidence supporting the idea that tumors, similar to normal adult tissues, arise from a specific stem-like cell population, the cancer stem cells (CSCs), which are considered as the real driving force behind tumor growth, the ability to metastasize, as well as resistance to conventional antitumor therapy. The concept that cancer growth recapitulates normal proliferative and/or regenerative processes, even though in very dysfunctional ways, has tremendous implications for cancer therapy. The rapid development of the CSC field, shoulder to shoulder with powerful genome-wide screening techniques, has provided cause for optimism for the development of more reliable therapies in the future. However, several important issues still lie ahead. Recent identification of a highly tumorigenic stem-like compartment and existence of urothelial differentiation programs in urothelial cell carcinomas (UCCs) raised important questions about UCC initiation and development. This review examines the present knowledge on CSCs in UCCs regarding the similarities between CSCs and the adult urothelial stem cells, potential origin of urothelial CSCs, main regulatory pathways, surface markers expression, and the current state of CSC-targeting therapeutic strategies.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1100/tsw.2010.138
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2075968-X
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  • 9
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    A unique case of hereditary bilateral segmental neurofibromatosis on the face
    FapUNIFESP (SciELO) ; 2012
    In:  Anais Brasileiros de Dermatologia Vol. 87, No. 6 ( 2012-12), p. 895-898
    Details
    In: Anais Brasileiros de Dermatologia, FapUNIFESP (SciELO), Vol. 87, No. 6 ( 2012-12), p. 895-898
    Abstract: A neurofibromatose segmentar é um achado clínico raro, geralmente com história familiar negativa e raro envolvimento facial. Existem quatro subtipos de neurofibromatose segmentar: segmentar verdadeira, segmentar com envolvimento visceral profundo, segmentar com história familiar e segmentar cutânea bilateral. Aqui nós reportamos três pacientes de uma mesma família (pai, filho e neta) com neurofibromatose segmentar bilateral na face. Esta forma ainda não foi relatada na literatura.
    Type of Medium: Online Resource
    ISSN: 0365-0596
    URL: Article
    DOI: 10.1590/S0365-05962012000600012
    Language: Unknown
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2012
    detail.hit.zdb_id: 2145422-X
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  • 10
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    Viral Infection in Renal Transplant Recipients
    Hindawi Limited ; 2012
    In:  The Scientific World Journal Vol. 2012 ( 2012), p. 1-18
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2012 ( 2012), p. 1-18
    Abstract: Viruses are among the most common causes of opportunistic infection after transplantation. The risk for viral infection is a function of the specific virus encountered, the intensity of immune suppression used to prevent graft rejection, and other host factors governing susceptibility. Although cytomegalovirus is the most common opportunistic pathogen seen in transplant recipients, numerous other viruses have also affected outcomes. In some cases, preventive measures such as pretransplant screening, prophylactic antiviral therapy, or posttransplant viral monitoring may limit the impact of these infections. Recent advances in laboratory monitoring and antiviral therapy have improved outcomes. Studies of viral latency, reactivation, and the cellular effects of viral infection will provide clues for future strategies in prevention and treatment of viral infections. This paper will summarize the major viral infections seen following transplant and discuss strategies for prevention and management of these potential pathogens.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1100/2012/820621
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2075968-X
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