In:
American Journal of Nephrology, S. Karger AG, Vol. 52, No. 5 ( 2021), p. 404-411
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Chronic kidney disease (CKD) is a risk factor for cardiovascular and all-cause mortality. Recognition of high-risk patients is important and could lead to a different approach and better treatment. The CHA 〈 sub 〉 2 〈 /sub 〉 DS 〈 sub 〉 2 〈 /sub 〉 -VASc score was originally used to predict cerebral infarction in patients with atrial fibrillation (AF), but it is also a useful predictor of outcome in other cardiovascular conditions, independent of AF. Therefore, the aim of our research was to assess the role of CHA 〈 sub 〉 2 〈 /sub 〉 DS 〈 sub 〉 2 〈 /sub 〉 -VASc score in predicting cardiovascular and all-cause mortality in CKD patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Stable nondialysis CKD patients were included. At the time of inclusion, medical history data and standard blood results were collected and CHA 〈 sub 〉 2 〈 /sub 〉 DS 〈 sub 〉 2 〈 /sub 〉 -VASc score was calculated. Patients were followed till the same end date, until kidney transplantation or until their death. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Eighty-seven CKD patients were included (60.3 ± 12.8 years, 66% male). Mean follow-up time was 1,696.5 ± 564.6 days. During the follow-up, 21 patients died and 11 because of cardiovascular reasons. Univariate Cox regression analysis showed that CHA 〈 sub 〉 2 〈 /sub 〉 DS 〈 sub 〉 2 〈 /sub 〉 -VASc score is a significant predictor of cardiovascular and all-cause mortality. In multivariate Cox regression analysis, in which CHA 〈 sub 〉 2 〈 /sub 〉 DS 〈 sub 〉 2 〈 /sub 〉 -VASc score, serum creatinine, urinary albumin/creatinine, hemoglobin, high-sensitivity C-reactive protein, and intact parathyroid hormone were included, CHA 〈 sub 〉 2 〈 /sub 〉 DS 〈 sub 〉 2 〈 /sub 〉 -VASc score was an independent predictor of cardiovascular (HR: 2.04, CI: 1.20–3.45, 〈 i 〉 p 〈 /i 〉 = 0.008) and all-cause mortality (HR: 2.06, CI: 1.43–2.97, 〈 i 〉 p 〈 /i 〉 = 0.001). The same was true after adding total cholesterol, triglycerides, and smoking status to both the analyses. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The CHA 〈 sub 〉 2 〈 /sub 〉 DS 〈 sub 〉 2 〈 /sub 〉 -VASc score is a simple, practical, and quick way to identify the risk for cardiovascular and all-cause mortality in CKD patients.
Type of Medium:
Online Resource
ISSN:
0250-8095
,
1421-9670
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
1468523-1
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