In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2022-1-4), p. e0262162-
Abstract:
Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247–567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to Spike-1 protein and the receptor-binding domain correlates strongly with viral neutralization in vitro . Furthermore, despite accounting for only approximately 12% of total immunoglobulin mass, collectively IgG3 and IgM account for approximately 80% of the total neutralization. This may have important implications for the development of potent therapies for COVID-19, as it indicates that hyperimmune globulins or convalescent plasma donations with high IgG3 concentrations may be a highly efficacious therapy.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0262162
DOI:
10.1371/journal.pone.0262162.g001
DOI:
10.1371/journal.pone.0262162.g002
DOI:
10.1371/journal.pone.0262162.g003
DOI:
10.1371/journal.pone.0262162.g004
DOI:
10.1371/journal.pone.0262162.t001
DOI:
10.1371/journal.pone.0262162.s001
DOI:
10.1371/journal.pone.0262162.s002
DOI:
10.1371/journal.pone.0262162.s003
DOI:
10.1371/journal.pone.0262162.s004
DOI:
10.1371/journal.pone.0262162.s005
DOI:
10.1371/journal.pone.0262162.s006
DOI:
10.1371/journal.pone.0262162.r001
DOI:
10.1371/journal.pone.0262162.r002
DOI:
10.1371/journal.pone.0262162.r003
DOI:
10.1371/journal.pone.0262162.r004
DOI:
10.1371/journal.pone.0262162.r005
DOI:
10.1371/journal.pone.0262162.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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