In:
Hormone and Metabolic Research, Georg Thieme Verlag KG, Vol. 54, No. 04 ( 2022-04), p. 238-249
Abstract:
Lipoprotein apheresis (LA) is currently the most powerful intervention possible
to reach a maximal reduction of lipids in patients with familial hypercholesterolemia and lipoprotein(a) hyperlipidemia. Although LA is an
invasive method, it has few side effects and the best results in preventing further major cardiovascular events. It has been suggested that the highly
significant reduction of cardiovascular complications in patients with severe lipid disorders achieved by LA is mediated not only by the potent reduction of
lipid levels but also by the removal of other proinflammatory and proatherogenic factors. Here we performed a comprehensive proteomic analysis of patients on LA
treatment using intra-individually a set of differently sized apheresis filters with the INUSpheresis system. This study revealed that proteomic analysis
correlates well with routine clinical chemistry in these patients. The method is eminently suited to discover new biomarkers and risk factors for cardiovascular
disease in these patients. Different filters achieve reduction and removal of proatherogenic proteins in different quantities. This includes not only
apolipoproteins, C-reactive protein, fibrinogen, and plasminogen but also proteins like complement factor B (CFAB), protein AMBP, afamin, and the low
affinity immunoglobulin gamma Fc region receptor III-A (FcγRIIIa) among others that have been described as atherosclerosis and metabolic vascular
diseases promoting factors. We therefore conclude that future trials should be designed to develop an individualized therapy approach for patients on LA based
on their metabolic and vascular risk profile. Furthermore, the power of such cascade filter treatment protocols may improve the prevention of cardiometabolic
disease and its complications.
Type of Medium:
Online Resource
ISSN:
0018-5043
,
1439-4286
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2022
detail.hit.zdb_id:
2056576-8
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