In:
Flavour and Fragrance Journal, Wiley, Vol. 26, No. 6 ( 2011-11), p. 447-451
Abstract:
The genotoxicity of 10 essential oil constituents was evaluated using the Drosophila melanogaster (Meigen) somatic mutation and recombination test, also known as the wing spot test, in the frame of a screening project aiming at evaluating the mutagenic activity of widely used substances, natural or not. Of the compounds that we tested here, l ‐carveol, dihydrocarveol, (+)‐dihydrocarvone, (−)‐fenchone and (−)‐carvyl acetate did not exhibit any mutagenic or recombinogenic activity, whereas (±)‐linalool, S ‐(+)‐carvone and S ‐(−)‐limonene gave inconclusive results. In contrast, α ‐phellandrene and R ‐(−)‐carvone significantly increased the frequency of mutant spots when compared with the negative control, suggesting mutagenic activity even at the lowest concentration used (1.5 µl/ml). Moreover, these data clearly demonstrate differences in activity between stereoisomers such as S ‐(+)‐ and R ‐(−)‐carvone. Given that α ‐phellandrene and R ‐(−)‐carvone are widely used compounds, further research is needed in order to have a better understanding of their activity and a clearer picture of their genotoxicity in order to decide whether they should remain or not in the lists of compounds that are safe to use. Copyright © 2011 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0882-5734
,
1099-1026
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1483463-7
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