Kooperativer Bibliotheksverbund

In: The Lancet Global Health, Elsevier BV, Vol. 11, No. 3 ( 2023-03), p. e361-e372

Type of Medium: Online Resource

ISSN: 2214-109X

URL: Article

DOI: 10.1016/S2214-109X(22)00514-9

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2723488-5

In: VNU Journal of Science: Medical and Pharmaceutical Sciences, Vietnam National University Journal of Science, Vol. 36, No. 1 ( 2020-03-24)

Abstract: Malignant hyperthermia (MH) is a clinical response happened to patient who is sensitive with inhaled anesthesia drug that could cause suddently death. Many previous studies showed that malignant hyperthermia strongly related to genetic background of patients including RYR1, CACNA1S or STAC3 gene polymorphisms. With the development of high technology such as next generation sequencing, scientists found that 37 to 86 percents of MH cases had RYR1 mutations and approximately 1 percent of those had CACNA1S mutations. Gene analysis testing was recommended to apply for patient with MH medical history or MH patient’s family relations. Keywords Malignant hyperthermia, inhaled anesthesia, RYR1, CACNA1S, STAC3. References [1] G. Torri, Inhalation anesthetics: a review, Minerva Anestesiologica 76 (2010) 215–228. [2] N. Kassiri, S. Ardehali, F. Rashidi, S. Hashemian, Inhalational anesthetics agents: The pharmacokinetic, pharmacodynamics, and their effects on human body, Biomed. Biotechnol. Res. J. BBRJ 2 (2018) 173. https://doi.org/10.4103/bbrj.bbrj_6618.[3] H. Rosenberg, N. Sambuughin, S. Riazi, R. Dirksen, Malignant Hyperthermia Susceptibility, in: M.P. Adam, H.H. Ardinger, R.A. Pagon, S.E. Wallace, L.J. Bean, K. Stephens, A. Amemiya (Eds.), GeneReviews, University of Washington, Seattle, Seattle (WA), 19932020. http://www.ncbi.nlm.nih.gov/books/NBK1146/ (accessed February 2, 2020).[4] H. Rosenberg, N. Pollock, A. Schiemann, T. Bulger, K. Stowell, Malignant hyperthermia: a review, Orphanet J. Rare Dis 10 (2015) 93. https://doi.org/10.1186/s13023-015-0310-1.[5] D. Carpenter, C. Ringrose, V. Leo, A. Morris, R.L. Robinson, P.J. Halsall, P.M. Hopkins, M.-A. Shaw, The role of CACNA1S in predisposition to malignant hyperthermia, BMC Med. Genet 10 (2009) 104. https://doi.org/10.1186/1471-2350-10-104.[6] S. Riazi, N. Kraeva, P.M. Hopkins, Updated guide for the management of malignant hyperthermia, Can. J. Anaesth. J. Can. Anesth 65 (2018) 709–721. https://doi.org/10.1007/s12630-018-1108-0.[7] S. Riazi, N. Kraeva, P.M. Hopkins, Malignant Hyperthermia in the Post-Genomics Era: New Perspectives on an Old Concept, Anesthesiology 128 (2018) 168–180. https://doi.org/10.1097/ALN.0000000000001878.[8] [D.M. Miller, C. Daly, E.M. Aboelsaod, L. Gardner, S.J. Hobson, K. Riasat, S. Shepherd, R.L. Robinson, J.G. Bilmen, P.K. Gupta, M.-A. Shaw, P.M. Hopkins, Genetic epidemiology of malignant hyperthermia in the UK, BJA Br. J. Anaesth 121 (2018) 944–952. https://doi.org/10.1016/j.bja.2018.06.028.[9] T.A. Beam, E.F. Loudermilk, D.F. Kisor, Pharmacogenetics and pathophysiology of CACNA1S mutations in malignant hyperthermia, Physiol. Genomics 49 (2017) 81–87. https://doi.org/10.1152/physiolgenomics.00126.2016.[10] I.T. Zaharieva, A. Sarkozy, P. Munot, A. Manzur, G. O’Grady, J. Rendu, E. Malfatti, H. Amthor, L. Servais, J.A. Urtizberea, O.A. Neto, E. Zanoteli, S. Donkervoort, J. Taylor, J. Dixon, G. Poke, A.R. Foley, C. Holmes, G. Williams, M. Holder, S. Yum, L. Medne, S. Quijano-Roy, N.B. Romero, J. Fauré, L. Feng, L. Bastaki, M.R. Davis, R. Phadke, C.A. Sewry, C.G. Bönnemann, H. Jungbluth, C. Bachmann, S. Treves, F. Muntoni, STAC3 variants cause a congenital myopathy with distinctive dysmorphic features and malignant hyperthermia susceptibility, Hum. Mutat 39 (2018) 1980–1994. https://doi.org/10.1002/humu.23635.[11] A.F. Dulhunty, The voltage-activation of contraction in skeletal muscle, Prog. Biophys. Mol. Biol 57 (1992) 181–223. https://doi.org/10.1016/0079-6107(92)90024-Z.[12] C. Franzini-Armstrong, A.O. Jorgensen, Structure and Development of E-C Coupling Units in Skeletal Muscle, Annu. Rev. Physiol 56 (1994) 509–534. https://doi.org/10.1146/annurev.ph.56.030194.002453.[13] D.H. MacLennan, M. Abu-Abed, C. Kang, Structure-function relationships in Ca(2+) cycling proteins, J. Mol. Cell. Cardiol 34 (2002) 897–918. https://doi.org/10.1006/jmcc.2002.2031.[14] H. Rosenberg, M. Davis, D. James, N. Pollock, K. Stowell, Malignant hyperthermia, Orphanet J. Rare Dis 2 (2007) 21. https://doi.org/10.1186/1750-1172-2-21.[15] S.M. Karan, F. Crowl, S.M. Muldoon, Malignant hyperthermia masked by capnographic monitoring, Anesth. Analg 78 (1994) 590–592. https://doi.org/10.1213/00000539-199403000-00029.[16] M.G. Larach, G.A. Gronert, G.C. Allen, B.W. Brandom, E.B. Lehman, Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006, Anesth. Analg 110 (2010) 498–507. https://doi.org/10.1213/ANE.0b013e3181c6b9b2.[17] M.G. Larach, A.R. Localio, G.C. Allen, M.A. Denborough, F.R. Ellis, G.A. Gronert, R.F. Kaplan, S.M. Muldoon, T.E. Nelson, H. Ording, H. Rosenberg, B.E. Waud, D.J. Wedel, A Clinical Grading Scale to Predict Malignant Hyperthermia Susceptibility, Anesthesiology 80 (1994) 771–779. https://doi.org/10.1097/00000542-199404000-00008.[18] D. Schneiderbanger, S. Johannsen, N. Roewer, F. Schuster, Management of malignant hyperthermia: diagnosis and treatment, Ther. Clin. Risk Manag 10 (2014) 355–362. https://doi.org/10.2147/TCRM.S47632.[19] R. Robinson, D. Carpenter, M.-A. Shaw, J. Halsall, P. Hopkins, Mutations in RYR1 in malignant hyperthermia and central core disease, Hum. Mutat 27 (2006) 977–989. https://doi.org/10.1002/humu.20356.[20] M.L. Alvarellos, R.M. Krauss, R.A. Wilke, R.B. Altman, T.E. Klein, PharmGKB summary: very important pharmacogene information for RYR1, Pharmacogenet. Genomics 26 (2016) 138–144. https://doi.org/10.1097/FPC.0000000000000198.[21] A. Merritt, P. Booms, M.-A. Shaw, D.M. Miller, C. Daly, J.G. Bilmen, K.M. Stowell, P.D. Allen, D.S. Steele, P.M. Hopkins, Assessing the pathogenicity of RYR1 variants in malignant hyperthermia, BJA Br. J. Anaesth 118 (2017) 533–543. https://doi.org/10.1093/bja/aex042.[22] P.M. Hopkins, H. Rüffert, M.M. Snoeck, T. Girard, K.P.E. Glahn, F.R. Ellis, C.R. Müller, A. Urwyler, European Malignant Hyperthermia Group, European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility, Br. J. Anaesth 115 (2015) 531–539. https://doi.org/10.1093/bja/aev225.[23] N.T. Thuy, L.N. Thanh, N.T.T. Mau, N.H. Hoang, N.T.K. Lien, D.D. Long, N.T. Bình, D.A. Tien, N.C. Huu, N.T. Hieu, P.T.H. Nhung, V.T. Thom, Whole exome sequencing revealed a pathogenic variant in a gene related to malignant hyperthermia in a Vietnamese cardiac surgical patient: A case report, Ann. Med. Surg 48 (2019) 88–90. https://doi.org/10.1016/j.amsu.2019.10.030.[24] B. Neuhuber, U. Gerster, F. Döring, H. Glossmann, T. Tanabe, B.E. Flucher, Association of calcium channel α1S and β1a subunits is required for the targeting of β1a but not of α1S into skeletal muscle triads, Proc. Natl. Acad. Sci. U. S. A 95 (1998) 5015–5020. https://doi.org/10.1073/pnas.95.9.5015.[25] M. Whirl-Carrillo, E.M. McDonagh, J.M. Hebert, L. Gong, K. Sangkuhl, C.F. Thorn, R.B. Altman, T.E. Klein, Pharmacogenomics Knowledge for Personalized Medicine, Clin. Pharmacol. Ther 92 (2012) 414–417. https://doi.org/10.1038/clpt.2012.96.[26] N. Monnier, V. Procaccio, P. Stieglitz, J. Lunardi, Malignant-hyperthermia susceptibility is associated with a mutation of the alpha 1-subunit of the human dihydropyridine-sensitive L-type voltage-dependent calcium-channel receptor in skeletal muscle, Am. J. Hum. Genet 60 (1997) 1316–1325 . https://doi.org/10.1086/515454.[27] S.L. Stewart, K. Hogan, H. Rosenberg, J.E. Fletcher, Identification of the Arg1086His mutation in the alpha subunit of the voltage-dependent calcium channel (CACNA1S) in a North American family with malignant hyperthermia, Clin. Genet 59 (2001) 178–184. https://doi.org/10.1034/j.1399 0004.2001.590306.x.[28] P.J. Toppin, T.T. Chandy, A. Ghanekar, N. Kraeva, W.S. Beattie, S. Riazi, A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene, Can. J. Anaesth. J. Can. Anesth 57 (2010) 689–693. https://doi.org/10.1007/s12630-010-9314-4.[29] E.J. Horstick, J.W. Linsley, J.J. Dowling, M.A. Hauser, K.K. McDonald, A. Ashley-Koch, L. Saint-Amant, A. Satish, W.W. Cui, W. Zhou, S.M. Sprague, D.S. Stamm, C.M. Powell, M.C. Speer, C. Franzini-Armstrong, H. Hirata, J.Y. Kuwada, Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy, Nat. Commun 4 (2013) 1952. https://doi.org/10.1038/ncomms2952.[30] D.S. Stamm, A.S. Aylsworth, J.M. Stajich, S.G. Kahler, L.B. Thorne, M.C. Speer, C.M. Powell, Native American myopathy: Congenital myopathy with cleft palate, skeletal anomalies, and susceptibility to malignant hyperthermia, Am. J. Med. Genet. A 146A (2008) 1832–1841. https://doi.org/10.1002/ajmg.a.32370.[31] A. Polster, B.R. Nelson, S. Papadopoulos, E.N. Olson, K.G. Beam, Stac proteins associate with the critical domain for excitation–contraction coupling in the II–III loop of CaV1.1, J. Gen. Physiol 150 (2018) 613–624. https://doi.org/10.1085/jgp.201711917.[32] S.M. Wong King Yuen, M. Campiglio, C.-C. Tung, B.E. Flucher, F. Van Petegem, Structural insights into binding of STAC proteins to voltage-gated calcium channels, Proc. Natl. Acad. Sci 114 (2017) E9520–E9528. https://doi.org/10.1073/pnas.1708852114.[33] M. Grabner, R.T. Dirksen, N. Suda, K.G. Beam, The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor, J. Biol. Chem 274 (1999) 21913–21919. https://doi.org/10.1074/jbc.274.31.21913.[34] J. Nakai, T. Tanabe, T. Konno, B. Adams, K.G. Beam, Localization in the II-III loop of the dihydropyridine receptor of a sequence critical for excitation-contraction coupling, J. Biol. Chem 273 (1998) 24983–24986. https://doi.org/10.1074/jbc.273.39.24983.[35] C.J. Morton, I.D. Campbell, SH3 domains. Molecular “Velcro,” Curr. Biol. CB 4 (1994) 615–617. https://doi.org/10.1016/s0960-9822(00)00134-2.[36] A. Zafra-Ruano, I. Luque, Interfacial water molecules in SH3 interactions: Getting the full picture on polyproline recognition by protein-protein interaction domains, FEBS Lett 586 (2012) 2619–2630. https://doi.org/10.1016/j.febslet.2012.04.057.        

Type of Medium: Online Resource

ISSN: 2588-1132 , 2615-9309

URL: Article

DOI: 10.25073/2588-1132/vnumps.4209

Language: Unknown

Publisher: Vietnam National University Journal of Science

Publication Date: 2020

In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 71, No. 10 ( 2020-12-17), p. 2679-2687

Abstract: Little is known about the natural history of asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods We conducted a prospective study at a quarantine center for coronavirus disease 2019 in Ho Chi Minh City, Vietnam. We enrolled quarantined people with reverse-transcription polymerase chain reaction (RT-PCR)–confirmed SARS-CoV-2 infection, collecting clinical data, travel and contact history, and saliva at enrollment and daily nasopharyngeal/throat swabs (NTSs) for RT-PCR testing. We compared the natural history and transmission potential of asymptomatic and symptomatic individuals. Results Between 10 March and 4 April 2020, 14 000 quarantined people were tested for SARS-CoV-2; 49 were positive. Of these, 30 participated in the study: 13 (43%) never had symptoms and 17 (57%) were symptomatic. Seventeen (57%) participants imported cases. Compared with symptomatic individuals, asymptomatic people were less likely to have detectable SARS-CoV-2 in NTS collected at enrollment (8/13 [62%] vs 17/17 [100%] ; P = .02). SARS-CoV-2 RNA was detected in 20 of 27 (74%) available saliva samples (7 of 11 [64%] in the asymptomatic group and 13 of 16 [81%] in the symptomatic group; P = .56). Analysis of RT-PCR positivity probability showed that asymptomatic participants had faster viral clearance than symptomatic participants (P  & lt; .001 for difference over the first 19 days). This difference was most pronounced during the first week of follow-up. Two of the asymptomatic individuals appeared to transmit SARS-CoV-2 to 4 contacts. Conclusions Asymptomatic SARS-CoV-2 infection is common and can be detected by analysis of saliva or NTSs. The NTS viral loads fall faster in asymptomatic individuals, but these individuals appear able to transmit the virus to others.

Type of Medium: Online Resource

ISSN: 1058-4838 , 1537-6591

URL: Article

DOI: 10.1093/cid/ciaa711

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2020

detail.hit.zdb_id: 2002229-3

In: Journal of Vietnamese Environment, Sachsische Landesbibliothek, Staats- und Universitatsbibliothek Dresden, Vol. 8, No. 5 ( 2017-01-17), p. 284-288

Abstract: The newly planned lead recycling zone in Dong Mai village has been operating with primary treatment systems using lime to neutralize acid in wastewater is a good sign for the local environment, yet the real problem that needs further attention and proper solutions is the accumulation of heavy metals typically lead (Pb) and cadmium (Cd) in agricultural land near the old Pb recycling area. In this context, 27 soil samples were collected and analyzed by AAS method to assess the situation and the quality of the agricultural soil. The results showed that the levels of Cd in the soil were still in acceptable level according to National Regulation. However, the lead contents in all of the soil samples exceeded National Regulation. The level of Pb pollution in soil was inversely proportional to the distance with old lead melting zone. The lead content in the soil sample collected at the distance of 50 m radius to the old melting zone reached 7070 ppm, which was 100 times higher than the allowable value of National Regulation. Khu tái chế chì mới tại thôn Đông Mai đã được quy hoạch và đi vào hoạt động cùng hệ thống xử lý sơ bộ với vôi bột là một tín hiệu đáng mừng cho môi trường nơi đây, nhưng vấn đề cần quan tâm và giải quyết triệt để là sự tích lũy một lượng lớn kim loại nặng điển hình là chì (Pb) và cađimi (Cd) trong đất nông nghiệp gần những khu tái chế chì cũ. 27 mẫu đất đã được thu thập và phân tích bằng phương pháp AAS để đánh giá tình trạng, chất lượng đất nông nghiệp tại đây. Kết quả cho thấy hàm lượng Cd trong đất vẫn trong mức độ cho phép theo Quy chuẩn quốc gia. Tuy nhiên, 100% các mẫu đất đều có hàm lượng chì vượt quá mức cho phép theo Quy chuẩn quốc gia. Mức độ ô nhiễm Pb trong đất tỷ lệ nghịch với khoảng cách tới khu lò nấu chì cũ. Mẫu đất cách 50 m so với khu vực lò cũ có hàm lượng chì lên tới 7070 ppm, gấp hơn 100 lần so với Quy chuẩn quốc gia.

Type of Medium: Online Resource

ISSN: 2193-6471

URL: Issue

URL: Article

DOI: 10.13141/jve.vol8.no5

DOI: 10.13141/jve.vol8.no5.pp284-288

Language: Unknown

Publisher: Sachsische Landesbibliothek, Staats- und Universitatsbibliothek Dresden

Publication Date: 2017

detail.hit.zdb_id: 2674408-9

In: TNU Journal of Science and Technology, Thai Nguyen University, Vol. 226, No. 14 ( 2021-09-16), p. 37-44

Abstract: Nghiên cứu này nhằm đánh giá thực trạng môi trường nước, đất và không khí bãi chôn lấp lợn dịch tả châu Phi tại tỉnh Thái Bình. Nghiên cứu thực địa đối với chất lượng nước mặt, nước ngầm, đất và không khí xung quanh các điểm chôn lấp trên địa bàn huyện Vũ Thư, Quỳnh Phụ, Hưng Hà và Tiền Hải. Kết quả nghiên cứu cho thấy, chất lượng môi trường nước quanh bãi chôn lấp được đặc trưng bởi các yếu tố ô nhiễm hữu cơ (BOD, COD) và amoni (NH4+) với mức nồng độ quan trắc được từ 6,0–183mg/L BOD5 và 11,5–78,2 mg/L COD trong nước ngầm quanh hố chôn lấp. Hầu hết các điểm chôn lấp đều có nồng độ H2S vượt ngưỡng cho phép (QCVN06:2009/BTNMT). Coliform trong nước mặt cạnh hố chôn cao gấp 10,1–25.833 lần so với quy chuẩn cho phép (7500 CFU/100mL). Đối với nước ngầm mật độ coliform cao gấp 100-33.566 lần so với quy chuẩn cho phép là 3 CFU/100ml. Trong môi trường đất có sự xuất hiện của colifirm nhưng không phát hiện có E.coli và Salmonela. Các nghiên cứu sâu về mối quan hệ giữa các yếu tố môi trường và hố chôn lấp cần được tiến hành sâu hơn để có hệ thống quản lý tốt hơn.

Type of Medium: Online Resource

ISSN: 2615-9562 , 2734-9098

URL: Article

DOI: 10.34238/tnu-jst.4701

Language: Unknown

Publisher: Thai Nguyen University

Publication Date: 2021

In: Tạp chí Y học Dự phòng, Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM), Vol. 31, No. 6 ( 2021-07-01), p. 154-163

Abstract: Nghiên cứu có thiết kế nghiên cứu mô tả cắt ngang với mục tiêu mô tả năng lực chuyên môn và nhu cầu đào tạo của bác sĩ chuyên ngành phục hồi chức năng tại 27 bệnh viện tuyến tỉnh, huyện và chuyên khoa tại các vùng sinh thái năm 2020 - 2021. Tổng số 205 bác sĩ tham gia nghiên cứu với số năm công tác trung bình là 8,53 năm, 6,35% bác sĩ có trình độ Tiến sĩ và bác sĩ chuyên khoa II, 21,95% bác sĩ chuyên khoa I, còn lại là bác sĩ nội trú, thạc sĩ và bác sĩ định hướng chuyên khoa. Có 80% cán bộ mong muốn được tiếp tục đào tạo thông qua các hình thức khác nhau trong đó đào tạo cập nhật kiến thức y tế liên tục chiếm tỷ lệ cao nhất (89,3 %); đặc biệt các bác sĩ mong muốn chương trình đào tạo nên bám sát chuẩn năng lực bác sĩ chuyên khoa; chương trình cần phải bám sát cơ cấu bệnh tật của từng vùng và từng tuyến. Nhìn chung các bác sĩ công tác trong chuyên ngành phục hồi chức năng cho rằng năng lực chuyên môn hiện tại đáp ứng một phần hoặc đầy đủ yêu cầu công việc (86,3%), còn 13,7% cho rằng chưa đáp ứng được yêu cầu. Nhu cầu đào tạo hiện nay là rất lớn đặc biệt nội dung đào tạo cần bám sát chuẩn năng lực bác sĩ chuyên khoa phục hồi chức năng.

Type of Medium: Online Resource

ISSN: 0868-2836

URL: Article

DOI: 10.51403/0868-2836/2021/387

Language: Unknown

Publisher: Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM)

Publication Date: 2021

In: SSRN Electronic Journal, Elsevier BV

Type of Medium: Online Resource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.3931736

Language: English

Publisher: Elsevier BV

Publication Date: 2021

In: Journal of Food Protection, Elsevier BV, Vol. 85, No. 5 ( 2022-05), p. 786-791

Type of Medium: Online Resource

ISSN: 0362-028X

URL: Article

DOI: 10.4315/JFP-21-444

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2093078-1

SSG: 21

In: The Lancet, Elsevier BV, Vol. 401, No. 10387 ( 2023-05), p. 1499-1507

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(23)00510-X

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

In: VNU Journal of Science: Education Research, Vietnam National University Journal of Science, ( 2020-10-27)

Abstract: Education quality assurance and accreditation is a vital quality management tool that helps higher education institutions, government agencies and the society to monitor the quality of higher education. In the organization of the quality assurance and accreditation activities in Vietnamese higher education institutions, the unification of views to measure the levels of quality assurance of the educational institutions in order to make appropriate judgements is a matter that receives particular concerns from not only higher education institutions, but accreditation agencies as well. This article discusses the toolkit for measuring the quality assurance level of higher education institutions, the process of developing and detailing the toolkit for its usage in the self-assessment and external assessment process in compliance with the set of quality assessment standards for higher education institutions issued by the Ministry of Education and Training. Besides, the authors also propose solutions for the implementation of the toolkit in quality assurance practices within higher education institutions and supporting assessors, accreditation bodies and government agencies for quality evaluation, monitoring and management.

Type of Medium: Online Resource

ISSN: 2588-1159 , 2615-9325

URL: Article

DOI: 10.25073/2588-1159/vnuer.4478

Language: Unknown

Publisher: Vietnam National University Journal of Science

Publication Date: 2020