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Figure 4 from: Li Z-Z, Wu S, Zhou C-Y, Liu Y, Hu G-W, Lehtonen S, Wang Q-F, Chen J-M (2019) Ottelia fengshanensis, a new bisexual species of Ottelia (Hydrocharitaceae) from southwestern China. PhytoKeys 135: 1-10. https://doi.org/10.3897/phytokeys.135.38531

Li, Zhi-Zhong ; Wu, Shuang ; Zhou, Chun-Yu ; [et al.]

Pensoft Publishers ; 2019

In: PhytoKeys Vol. 135 ( 2019-10-30), p. 1-10

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In: PhytoKeys, Pensoft Publishers, Vol. 135 ( 2019-10-30), p. 1-10

Abstract: Ottelia fengshanensis , a new species (Hydrocharitaceae) from southwest China is here described and illustrated. Comparing its morphological features to putative close relatives O. guanyangensis , it has 3–4 flowers (vs. 2–5) each spathe, hexagonal-cylindric fruit, white styles (vs. yellow), green leaves (vs. dark green) and fruit tiny winged (vs. winged obviously). Molecular phylogenetic investigation of four DNA sequences (ITS, rbc L, trn K5’ intron and trn S- trn G) and the Poisson Tree Processes model for species delimitation (PTP) analysis, further resolves O. fengshanensis as a new species that is close to O. guanyangensis with distinct support.

Type of Medium: Online Resource

ISSN: 1314-2003 , 1314-2011

URL: Article

DOI: 10.3897/phytokeys.135.38531

DOI: 10.3897/phytokeys.135.38531.figure1

DOI: 10.3897/phytokeys.135.38531.figure2

DOI: 10.3897/phytokeys.135.38531.figure3

DOI: 10.3897/phytokeys.135.38531.figure4

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2019

detail.hit.zdb_id: 2579891-1

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Increased Interleukin-17 and Glucocorticoid Receptor-β Expression in Interstitial Lung Diseases and Corticosteroid Insensitivity

Lo, Chun-Yu ; Wang, Chun-Hua ; Wang, Chih-Wei ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Immunology Vol. 13 ( 2022-7-5)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-7-5)

Abstract: Treatment responsiveness to corticosteroids is excellent for cryptogenic organizing pneumonia (COP) and sarcoidosis, but suboptimal for idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia (UIP). We hypothesise that the differential expression of IL-17 contributes to variable corticosteroid sensitivity in different interstitial lung diseases. Objective To determine the associations among expression of IL-17, glucocorticoid receptor-β and responsiveness to corticosteroid treatment in interstitial lung diseases. Methods Immunohistochemical (IHC) staining was performed on formalin-fixed paraffin-embedded (FFPE) lung tissues obtained by bronchoscopic, CT-guided or surgical biopsies, and quantified by both cell counting (% positive cells) by individuals and by software IHC Profiler plugin of ImageJ (opacity density score). We studied the effect of IL-17 on corticosteroid sensitivity in human fibroblast MRC5 cell line. Results Compared with specimens from patients with COP (n =13) and sarcoidosis (n =13), those from IPF patients (n = 21) had greater GR-β and IL-17 expression and neutrophil infiltration. Radiographic progression after oral corticosteroid treatment was positively correlated with the expression in IL-17 and GR-β/GR-α ratio in all patients (COP, sarcoidosis and IPF) and also within the IPF subgroup only. IL-17 expression level was positively associated with GR-β and GR-β/GR-α ratio. In MRC5 cells, exogenous IL-17 increased the production of collagen I and up-regulated GR-β expression and dexamethasone’s suppressive effect on collagen I production was impaired by IL-17, and silencing IL-17 receptor A gene attenuated the effect of IL-17. Conclusion Up-regulation of GR-β/GR-α ratio by IL-17 could be associated with the relative corticosteroid-insensitivity of IPF.

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/fimmu.2022.905727

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2606827-8

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Data_Sheet_1.docx

Huang, Hung-Yu ; Chung, Fu-Tsai ; Lin, Chun-Yu ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Medicine Vol. 8 ( 2022-1-21)

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In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2022-1-21)

Abstract: Bronchiectasis is characterized by systemic inflammation and multiple comorbidities. This study aimed to investigate the clinical outcomes based on the bronchiectasis etiology comorbidity index (BACI) score in patients hospitalized for severe bronchiectasis exacerbations. We included non-cystic fibrosis patients hospitalized for severe bronchiectasis exacerbations between January 2008 and December 2016 from the Chang Gung Research Database (CGRD) cohort. The main outcome was the 1-year mortality rate after severe exacerbations. We used the Cox regression model to assess the risk factors of 1-year mortality. Of 1,235 patients who were hospitalized for severe bronchiectasis exacerbations, 641 were in the BACI & lt; 6 group and 594 in the BACI ≥ 6 group. The BACI ≥ 6 group had more previous exacerbations and a lower FEV 1 . Pseudomonas aeruginosa (19.1%) was the most common bacterium, followed by Klebsiella pneumoniae (7.5%). Overall, 11.8% of patients had respiratory failure and the hospital mortality was 3.0%. After discharge, compared to the BACI & lt; 6 group, the BACI ≥ 6 group had a significantly higher cumulative incidence of respiratory failure and mortality in a 1-year follow-up. The risk factors for 1-year mortality in a multivariate analysis include age [hazard ratio (HR) 4.38, p = 0.01], being male (HR 4.38, p = 0.01), and systemic corticosteroid usage (HR 6.35, p = 0.001), while airway clearance therapy (ACT) (HR 0.50, p = 0.010) was associated with a lower mortality risk. An increased risk of respiratory failure and mortality in a 1-year follow-up after severe exacerbations was observed in bronchiectasis patients with multimorbidities, particularly older age patients, male patients, and patients with a history of systemic corticosteroid use. ACT could effectively improve the risk for 1-year mortality.

Type of Medium: Online Resource

ISSN: 2296-858X

URL: Article

DOI: 10.3389/fmed.2021.812775

DOI: 10.3389/fmed.2021.812775.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2775999-4

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Clinical manifestations and outcomes of fungus-associated asthma: A multi-institution database study in Taiwan

Lo, Yu-Lun ; Lin, Horng-Chyuan ; Lo, Chun-Yu ; [et al.]

Elsevier BV ; 2023

In: Microbiological Research Vol. 266 ( 2023-01), p. 127234-

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In: Microbiological Research, Elsevier BV, Vol. 266 ( 2023-01), p. 127234-

Type of Medium: Online Resource

ISSN: 0944-5013

URL: Article

DOI: 10.1016/j.micres.2022.127234

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2051526-1

detail.hit.zdb_id: 1189614-0

SSG: 12

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, Daniel J. ; Abdel-Aziz, Amal Kamal ; Abdelfatah, Sara ; [et al.]

Informa UK Limited ; 2021

In: Autophagy Vol. 17, No. 1 ( 2021-01-02), p. 1-382

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In: Autophagy, Informa UK Limited, Vol. 17, No. 1 ( 2021-01-02), p. 1-382

Type of Medium: Online Resource

ISSN: 1554-8627 , 1554-8635

URL: Article

DOI: 10.1080/15548627.2020.1797280

Language: English

Publisher: Informa UK Limited

Publication Date: 2021

detail.hit.zdb_id: 2262043-6

SSG: 12

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Corrigendum to: The TianQin project: current progress on science and technology

Mei, Jianwei ; Bai, Yan-Zheng ; Bao, Jiahui ; [et al.]

Oxford University Press (OUP) ; 2021

In: Progress of Theoretical and Experimental Physics Vol. 2021, No. 5 ( 2021-05-18)

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In: Progress of Theoretical and Experimental Physics, Oxford University Press (OUP), Vol. 2021, No. 5 ( 2021-05-18)

Type of Medium: Online Resource

ISSN: 2050-3911

URL: Article

DOI: 10.1093/ptep/ptaa165

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 2705045-2

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The TianQin project: Current progress on science and technology

Mei, Jianwei ; Bai, Yan-Zheng ; Bao, Jiahui ; [et al.]

Oxford University Press (OUP) ; 2021

In: Progress of Theoretical and Experimental Physics Vol. 2021, No. 5 ( 2021-05-18)

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In: Progress of Theoretical and Experimental Physics, Oxford University Press (OUP), Vol. 2021, No. 5 ( 2021-05-18)

Abstract: TianQin is a planned space-based gravitational wave (GW) observatory consisting of three Earth-orbiting satellites with an orbital radius of about $10^5 \, {\rm km}$. The satellites will form an equilateral triangle constellation the plane of which is nearly perpendicular to the ecliptic plane. TianQin aims to detect GWs between $10^{-4} \, {\rm Hz}$ and $1 \, {\rm Hz}$ that can be generated by a wide variety of important astrophysical and cosmological sources, including the inspiral of Galactic ultra-compact binaries, the inspiral of stellar-mass black hole binaries, extreme mass ratio inspirals, the merger of massive black hole binaries, and possibly the energetic processes in the very early universe and exotic sources such as cosmic strings. In order to start science operations around 2035, a roadmap called the 0123 plan is being used to bring the key technologies of TianQin to maturity, supported by the construction of a series of research facilities on the ground. Two major projects of the 0123 plan are being carried out. In this process, the team has created a new-generation $17 \, {\rm cm}$ single-body hollow corner-cube retro-reflector which was launched with the QueQiao satellite on 21 May 2018; a new laser-ranging station equipped with a $1.2 \, {\rm m}$ telescope has been constructed and the station has successfully ranged to all five retro-reflectors on the Moon; and the TianQin-1 experimental satellite was launched on 20 December 2019—the first-round result shows that the satellite has exceeded all of its mission requirements.

Type of Medium: Online Resource

ISSN: 2050-3911

URL: Article

DOI: 10.1093/ptep/ptaa114

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2021

detail.hit.zdb_id: 2705045-2

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Both epilepsy and anti‐seizure medications affect bone metabolism in children with self‐limited epilepsy with centrotemporal spikes

Shi, Xiu‐Yu ; Ju, Jun ; Lu, Qian ; [et al.]

Wiley ; 2023

In: Epilepsia

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In: Epilepsia, Wiley

Abstract: Bone metabolism can be influenced by a range of factors. We selected children with self‐limited epilepsy with centrotemporal spikes (SeLECTS) and lifestyles similar to those of healthy children to control for the confounding factors that may influence bone metabolism. We aimed to identify the specific effects of epilepsy and/or anti‐seizure medications (ASMs) on bone metabolism. Methods Patients with SeLECTS were divided into an untreated group and a monotherapy group, and the third group was a healthy control group. We determined the levels of various biochemical markers of bone metabolism, including procollagen type I nitrogenous propeptide (PINP), alkaline phosphatase (ALP), osteocalcin (OC), collagen type I cross‐linked C‐telopeptide (CTX), calcium, magnesium, phosphorus, parathyroid hormone (PTH), and vitamin D 3 (VD 3 ). Results A total of 1487 patients (from 19 centers) were diagnosed with SeLECTS; 1032 were analyzed, including 117 patients who did not receive any ASMs (untreated group), 643 patients who received only one ASM (monotherapy group), and 272 children in the healthy control group. Except for VD 3 , other bone metabolism of the three groups were different ( p 〈 .001). Bone metabolism was significantly lower in the untreated group than the healthy control group (p 〈 .05). There were significant differences between the monotherapy and healthy control group in the level of many markers. However, when comparing the monotherapy and untreated groups, the results were different; oxcarbazepine, levetiracetam, and topiramate had no significant effect on bone metabolism. Phosphorus and magnesium were significantly lower in the valproic acid group than the untreated group (adjusted p 〈 .05, Cliff's delta .282–.768). CTX was significantly higher in the lamotrigine group than in the untreated group (adjusted p = .012, Cliff's delta = .316). Significance Epilepsy can affect many aspects of bone metabolism. After controlling epilepsy and other confounders that affect bone metabolism, we found that the effects of ASMs on bone metabolism differed. Oxcarbazepine, levetiracetam, and topiramate did not affect bone metabolism, and lamotrigine corrected some of the abnormal markers of bone metabolism in patients with epilepsy.

Type of Medium: Online Resource

ISSN: 0013-9580 , 1528-1167

URL: Article

DOI: 10.1111/epi.17733

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2002194-X

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Nationwide surveillance of antimicrobial resistance in invasive isolates of Streptococcus pneumoniae in Taiwan from 2017 to 2019

Tsai, Yu-Te ; Lee, Yu-Lin ; Lu, Min-Chi ; [et al.]

Elsevier BV ; 2022

In: Journal of Microbiology, Immunology and Infection Vol. 55, No. 2 ( 2022-04), p. 215-224

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In: Journal of Microbiology, Immunology and Infection, Elsevier BV, Vol. 55, No. 2 ( 2022-04), p. 215-224

Type of Medium: Online Resource

ISSN: 1684-1182

URL: Article

DOI: 10.1016/j.jmii.2021.05.008

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2175858-X

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Actionable pharmacogenetic variants in Hong Kong Chinese exome sequencing data and projected prescription impact in the Hong Kong population

Yu, Mullin Ho Chung ; Chan, Marcus Chun Yin ; Chung, Claudia Ching Yan ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Genetics Vol. 17, No. 2 ( 2021-2-18), p. e1009323-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 17, No. 2 ( 2021-2-18), p. e1009323-

Abstract: Preemptive pharmacogenetic testing has the potential to improve drug dosing by providing point-of-care patient genotype information. Nonetheless, its implementation in the Chinese population is limited by the lack of population-wide data. In this study, secondary analysis of exome sequencing data was conducted to study pharmacogenomics in 1116 Hong Kong Chinese. We aimed to identify the spectrum of actionable pharmacogenetic variants and rare, predicted deleterious variants that are potentially actionable in Hong Kong Chinese, and to estimate the proportion of dispensed drugs that may potentially benefit from genotype-guided prescription. The projected preemptive pharmacogenetic testing prescription impact was evaluated based on the patient prescription data of the public healthcare system in 2019, serving 7.5 million people. Twenty-nine actionable pharmacogenetic variants/ alleles were identified in our cohort. Nearly all (99.6%) subjects carried at least one actionable pharmacogenetic variant, whereas 93.5% of subjects harbored at least one rare deleterious pharmacogenetic variant. Based on the prescription data in 2019, 13.4% of the Hong Kong population was prescribed with drugs with pharmacogenetic clinical practice guideline recommendations. The total expenditure on actionable drugs was 33,520,000 USD, and it was estimated that 8,219,000 USD (24.5%) worth of drugs were prescribed to patients with an implicated actionable phenotype. Secondary use of exome sequencing data for pharmacogenetic analysis is feasible, and preemptive pharmacogenetic testing has the potential to support prescription decisions in the Hong Kong Chinese population.

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1009323

DOI: 10.1371/journal.pgen.1009323.g001

DOI: 10.1371/journal.pgen.1009323.g002

DOI: 10.1371/journal.pgen.1009323.g003

DOI: 10.1371/journal.pgen.1009323.g004

DOI: 10.1371/journal.pgen.1009323.t001

DOI: 10.1371/journal.pgen.1009323.s001

DOI: 10.1371/journal.pgen.1009323.s002

DOI: 10.1371/journal.pgen.1009323.s003

DOI: 10.1371/journal.pgen.1009323.s004

DOI: 10.1371/journal.pgen.1009323.s005

DOI: 10.1371/journal.pgen.1009323.s006

DOI: 10.1371/journal.pgen.1009323.s007

DOI: 10.1371/journal.pgen.1009323.s008

DOI: 10.1371/journal.pgen.1009323.s009

DOI: 10.1371/journal.pgen.1009323.s010

DOI: 10.1371/journal.pgen.1009323.s011

DOI: 10.1371/journal.pgen.1009323.s012

DOI: 10.1371/journal.pgen.1009323.s013

DOI: 10.1371/journal.pgen.1009323.s014

DOI: 10.1371/journal.pgen.1009323.s015

DOI: 10.1371/journal.pgen.1009323.s016

DOI: 10.1371/journal.pgen.1009323.s017

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2186725-2

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