In:
International Journal of Endocrinology, Hindawi Limited, Vol. 2016 ( 2016), p. 1-5
Abstract:
Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs at lumbar spine (L2–4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), and creatinine (Cr) were also tested. Data analyses revealed that serum UA levels were positively associated with BMD at all sites ( p 〈 0.05 ) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight ( r = 0.322 ), body mass index (BMI) ( r = 0.331 ), Ca ( r = 0.179 ), and Cr ( r = 0.239 ) ( p 〈 0.001 ) and were also positively associated with the concentrations of PTH ( r = 0.10 , p 〈 0.05 ). When compared with those in the lowest tertile of UA levels, men with T2DM in the highest tertile had a lower prevalence of osteoporosis or osteopenia (adjusted odds ratio 0.54, 95% confidence interval [CI] 0.31–0.95). These data suggest that higher serum levels of UA are associated with higher BMDs and lower risks of osteoporosis in Chinese men with T2DM.
Type of Medium:
Online Resource
ISSN:
1687-8337
,
1687-8345
DOI:
10.1155/2016/2528956
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2502951-4
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