In:
Journal of Digestive Diseases, Wiley, Vol. 19, No. 8 ( 2018-08), p. 498-507
Abstract:
Few studies have reported the association between nonalcoholic fatty liver disease (NAFLD) and immunoglobulins. In this study, we aimed to investigate the relationship between serum immunoglobulin levels and NAFLD in a Chinese adult population. METHODS We performed a cross‐sectional study including 11 261 Chinese adults. NAFLD was diagnosed based on the Chinese Guidelines for the diagnosis and treatment of fatty liver diseases and an alcohol intake of 〈 70 g/week in women and 〈 140 g/week in men, and serum immunoglobulin (Ig) levels were determined using immune nephelometry. Multiple logistic regression analysis was done to assess relationships between concentrations of serum immunoglobulins and NAFLD. RESULTS Of the 11 261 adults recruited from January 2010 to December 2015, the prevalence of NAFLD was 40.8% ( n = 4598). The geometric mean levels of IgG, IgM, IgE and IgA were 1177.49 mg/dL (95% confidence interval [CI] 1173.07–1181.93), 93.56 mg/dL (95% CI 92.70–94.42), 30.70 IU/mL (95% CI 29.92–31.49) and 216.64 mg/dL (95% CI 214.95–218.34), respectively. Compared with the lowest quintile, the multivariable adjusted odds ratio (95% CI) of NAFLD for the highest quintile of IgG, IgM, IgE, and IgA were 0.78 (0.66–0.92), 0.71 (0.60–0.84), 0.98 (0.84–1.15) and 1.41 (1.21–1.66), respectively. CONCLUSION Increased IgA and decreased IgG and IgM levels are independently associated with NAFLD prevalence. Further research is needed to explore the causal association between serum immunoglobulins and NAFLD.
Type of Medium:
Online Resource
ISSN:
1751-2972
,
1751-2980
DOI:
10.1111/cdd.2018.19.issue-8
DOI:
10.1111/1751-2980.12646
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2317117-0
Bookmarklink