In:
Otolaryngology–Head and Neck Surgery, Wiley, Vol. 144, No. 4 ( 2011-04), p. 632-638
Abstract:
To report improvement of obstructive sleep apnea syndrome (OSAS) and changes of high‐sensitivity C‐reactive protein (hs‐CRP) concentrations after relocation pharyngoplasty (RP), a high variant of uvulopalatopharyngoplasty. Study Design Prospective comparative study. Setting Tertiary referral center. Subjects and Methods Thirty consecutive OSAS patients without a preexisting diagnosis of cardiovascular disease who underwent RP were assessed for body mass index (BMI), Epworth Sleepiness Scale (ESS), sleep apnea‐hypopnea index (AHI), and serum levels of hs‐CRP at baseline and 6 months postoperatively. Results Of the subjects, the mean values of age, BMI, ESS, AHI, and hs‐CRP were 39.5 ± 7.0 years, 27.5 ± 4.5 kg/m 2 , 10.8 ± 4.2, 46.2 ± 22.9 events/hour, and 2.06 ± 1.78 mg/L, respectively. After 6 months postoperatively, RP reduced the ESS (Δ = −4.3 ± 4.5, P 〈 . 001) and AHI (Δ = −28.3 ± 21.1, P 〈 . 001) and levels of hs‐CRP (Δ = −0.67 ± 1.36, P =. 012) significantly, whereas BMI measurements were indifferent (Δ = −0.42 ± 1.28, P =. 073). Moreover, the changes of AHI and hs‐CRP were particularly remarkable in patients with very severe OSAS (AHI ≥60). Conclusion Although many OSAS patients remain in the mild‐moderate category, equivalent improvements in excessive daytime sleepiness and reductions of hs‐CRP concentrations indicate that reduction of AHI is not all that matters after RP.
Type of Medium:
Online Resource
ISSN:
0194-5998
,
1097-6817
DOI:
10.1177/0194599810395104
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
2008453-5
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