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supp1-3235978.pdf

Liu, Zixuan ; Song, Xiaoyu ; Wang, Zhuowei ; [et al.]

Institute of Electrical and Electronics Engineers (IEEE) ; 2023

In: IEEE Transactions on Computers Vol. 72, No. 7 ( 2023-7-1), p. 2111-2119

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In: IEEE Transactions on Computers, Institute of Electrical and Electronics Engineers (IEEE), Vol. 72, No. 7 ( 2023-7-1), p. 2111-2119

Type of Medium: Online Resource

ISSN: 0018-9340 , 1557-9956 , 2326-3814

URL: Article

DOI: 10.1109/TC.2023.3235978

DOI: 10.1109/TC.2023.3235978/mm1

RVK:

SA 5560

RVK:

SQ 1100

Language: Unknown

Publisher: Institute of Electrical and Electronics Engineers (IEEE)

Publication Date: 2023

detail.hit.zdb_id: 1473005-4

detail.hit.zdb_id: 218504-0

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Author Correction: Robust estimation of bacterial cell count from optical density

Beal, Jacob ; Farny, Natalie G. ; Haddock-Angelli, Traci ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Communications Biology Vol. 3, No. 1 ( 2020-10-27)

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In: Communications Biology, Springer Science and Business Media LLC, Vol. 3, No. 1 ( 2020-10-27)

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Type of Medium: Online Resource

ISSN: 2399-3642

URL: Article

DOI: 10.1038/s42003-020-01371-9

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2919698-X

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Robust estimation of bacterial cell count from optical density

Beal, Jacob ; Farny, Natalie G. ; Haddock-Angelli, Traci ; [et al.]

Springer Science and Business Media LLC ; 2020

In: Communications Biology Vol. 3, No. 1 ( 2020-09-17)

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In: Communications Biology, Springer Science and Business Media LLC, Vol. 3, No. 1 ( 2020-09-17)

Abstract: Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli . Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals 〈 1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data.

Type of Medium: Online Resource

ISSN: 2399-3642

URL: Article

DOI: 10.1038/s42003-020-01127-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2919698-X

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Comparative effectiveness of palbociclib plus aromatase inhibitor versus fulvestrant alone as initial endocrine therapy for HR+/HER2- advanced breast cancer in Chinese clinical practice: A real-world study.

Yue, Jian ; Yuan, Peng ; Wang, Xue ; [et al.]

American Society of Clinical Oncology (ASCO) ; 2023

In: Journal of Clinical Oncology Vol. 41, No. 16_suppl ( 2023-06-01), p. e13057-e13057

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In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 41, No. 16_suppl ( 2023-06-01), p. e13057-e13057

Abstract: e13057 Background: In the real world, there are still a large number of HR+/HER2- advanced breast cancer patients receiving initial endocrine therapy with fulvestrant monotherapy in China, especially patients with bone metastases only. It is due to lack of data comparing the effective between Palbociclib combined with AI and fulvestrant monotherapy as initial endocrine therapy. On the other hand, there are economic factors and access issues. According to the National Cancer Center's previous clinical experience, Palbociclib combined with AI is superior to fulvestrant monotherapy in HR+/HER2- advanced breast cancer patients receiving initial endocrine therapy. Therefore, we collected and summarized the previous clinical data in our center to compare the effective of Palbociclib combined with AI and fulvestrant monotherapy for HR+/ HER2-advanced breast cancer patients receiving initial endocrine therapy in China. Methods: This is a retrospective real-world experience aimed at verifying the effective of Palbociclib combined with AI and fulvestrant monotherapy for HR+/ HER2-advanced breast cancer patients receiving initial endocrine therapy in China. The primary aim was rwPFS; secondary aims were overall survival, and objective response rate. Patients received Palbociclib combined with AI or fulvsetrant monotherapy. Results: In total, 346 patients were enrolled, 193 to Palbociclib plus AI and 153 to fulvestrant monotherapy. Median age was 55 years (range 28-88); 191 had visceral involvement (116 in Palbociclib plus AI group and 75 in fulvestrant group). At a median follow up of 38 months (range 4-78). The median PFS was 20.0 months (95% CI 17.3–22.7) in the Palbociclib plus AI group and 12 months (95% CI 9.6–14.3) in the fulvestrant group (hazard ratio 0.593, 95% CI 0.470–0.749, p 〈 0·0001). The 6-month progression-free rate was 83.9% in the Palbociclib plus AI group and 75.8% in fulvestrant group. The 6-month progression-free rate was 83.9% in the Palbociclib plus AI group and 75.8% in fulvestrant group. The 12-month progression-free rate was 65.8% in the Palbociclib plus AI group and 46.4% in fulvestrant monotherapy group. The over survival was not reached in the Palbociclib plus AI group and it was 65 months (95% CI 55.6–75.4) in the fulvestrant group. Grade 3-4 adverse events occurred in Palbociclib plus AI group. The most common grade 3 or 4 adverse events were neutropenia (47.7%) and leucopenia (27.5%) in the Palbociclib plus AI group. Conclusions: The efficacy of palbociclib plus AI is worthy of recognition and the toxicity was acceptable. Compared with fulvestrant monotherapy in HR+/HER2- advanced breast cancer patients receiving initial endocrine therapy, Palbociclib plus AI might have a better survival. Clinical trial information: NCT05000736 .

Type of Medium: Online Resource

ISSN: 0732-183X , 1527-7755

URL: Article

DOI: 10.1200/JCO.2023.41.16_suppl.e13057

RVK:

XA 52760

RVK:

XA 10000

Language: English

Publisher: American Society of Clinical Oncology (ASCO)

Publication Date: 2023

detail.hit.zdb_id: 2005181-5

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Quantitative proteomic analysis of cortex in the depressive-like behavior of rats induced by the simulated complex space environment

Min, Rui ; Chen, Zixuan ; Wang, Yun ; [et al.]

Elsevier BV ; 2021

In: Journal of Proteomics Vol. 237 ( 2021-04), p. 104144-

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In: Journal of Proteomics, Elsevier BV, Vol. 237 ( 2021-04), p. 104144-

Type of Medium: Online Resource

ISSN: 1874-3919

URL: Article

DOI: 10.1016/j.jprot.2021.104144

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2400835-7

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Video_3.MP4

Guo, Jincheng ; Wang, Guozhong ; Li, Zixuan ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-10-28)

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In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-10-28)

Abstract: The effect of a single transradial guiding catheter (STGC) for culprit vessel percutaneous coronary intervention (PCI) first on door-to-balloon (D2B) time remains unclear. Materials and methods Between February 2017 and July 2019, 560 patients with ST-elevation myocardial infarction (STEMI) were randomized into either the STGC group ( n = 280) or the control group ( n = 280) according to direct culprit vessel PCI with a STGC. In the STGC group, a dedicated transraidal guiding catheter (6F either MAC3.5 or JL3.5) was used for the treatment of electrocardiogram (ECG)-guided culprit vessel first and later contralateral angiography. In the control group, a universal diagnostic catheter (5F Tiger II) was used for complete coronary angiography, followed by guiding catheter selection for culprit vessel PCI. The primary endpoint was D2B time, and the secondary endpoint included catheterization laboratory door-to-balloon (C2B), procedural, fluoroscopy times, and major adverse cardiac events (MACE) at 30 days. Results The median D2B time was significantly shorter in the STGC group compared to the control group (53.9 vs. 58.4 min; p = 0.003). The C2B, procedural, and fluoroscopy times were also shorter in the STGC group (C2B: 17.3 vs. 24.5 min, p & lt; 0.001; procedural: 45.2 vs. 49.0 min, p = 0.012; and fluoroscopy: 9.7 vs. 11.3 min, p = 0.025). More patients achieved the goal of D2B time within 90 min (93.9% vs. 87.1%, p = 0.006) and 60 min (61.4% vs. 51.1%, p = 0.013) in the STGC group. Radial artery perforation (RAP) was significantly reduced in the STGC group compared with the control group (0.7% vs. 3.2%, P = 0.033). MACE at 30 days was similar (2.5% vs. 4.6%, P = 0.172) between the two groups. Conclusion ECG-guided immediate intervention on culprit vessel with a STGC can reduce D2B, C2B, procedural, and fluoroscopy times (ECG-guided Immediate Primary PCI for Culprit Vessel to Reduce Door to Device Time; NCT03272451).

Type of Medium: Online Resource

ISSN: 2297-055X

URL: Article

DOI: 10.3389/fcvm.2022.1022488

DOI: 10.3389/fcvm.2022.1022488.s001

DOI: 10.3389/fcvm.2022.1022488.s002

DOI: 10.3389/fcvm.2022.1022488.s003

DOI: 10.3389/fcvm.2022.1022488.s004

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2781496-8

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An Adhesive Bioink toward Biofabrication under Wet Conditions

Li, Wanlu ; Wang, Mian ; Wang, Shiwei ; [et al.]

Wiley ; 2023

In: Small

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In: Small, Wiley

Abstract: Three‐dimensional (3D) bioprinting is driving significant innovations in biomedicine over recent years. Under certain scenarios such as in intraoperative bioprinting, the bioinks used should exhibit not only cyto/biocompatibility but also adhesiveness in wet conditions. Herein, an adhesive bioink composed of gelatin methacryloyl, gelatin, methacrylated hyaluronic acid, and skin secretion of Andrias davidianus is designed. The bioink exhibits favorable cohesion to allow faithful extrusion bioprinting in wet conditions, while simultaneously showing good adhesion to a variety of surfaces of different chemical properties, possibly achieved through the diverse bonds presented in the bioink formulation. As such, this bioink is able to fabricate sophisticated planar and volumetric constructs using extrusion bioprinting, where the dexterity is further enhanced using ergonomic handheld bioprinters to realize in situ bioprinting. In vitro experiments reveal that cells maintain high viability; further in vivo studies demonstrate good integration and immediate injury sealing. The characteristics of the bioink indicate its potential widespread utility in extrusion bioprinting and will likely broaden the applications of bioprinting toward situations such as in situ dressing and minimally invasive tissue regeneration.

Type of Medium: Online Resource

ISSN: 1613-6810 , 1613-6829

URL: Article

DOI: 10.1002/smll.202205078

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2168935-0

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Influence of PC60BM or PC70BM as electron acceptor on the performance of polymer solar cells

Zhang, Fujun ; Zhuo, Zuliang ; Zhang, Jian ; [et al.]

Elsevier BV ; 2012

In: Solar Energy Materials and Solar Cells Vol. 97 ( 2012-2), p. 71-77

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In: Solar Energy Materials and Solar Cells, Elsevier BV, Vol. 97 ( 2012-2), p. 71-77

Type of Medium: Online Resource

ISSN: 0927-0248

URL: Article

DOI: 10.1016/j.solmat.2011.09.006

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 2012677-3

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Impact of prediabetes and duration of diabetes on radial artery atherosclerosis in acute coronary syndrome patients: An optical coherence tomography study

Li, Zixuan ; Tang, Zhe ; Wang, Yujie ; [et al.]

SAGE Publications ; 2022

In: Diabetes and Vascular Disease Research Vol. 19, No. 1 ( 2022-01), p. 147916412210781-

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In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 19, No. 1 ( 2022-01), p. 147916412210781-

Abstract: Prediabetes (PDM) and diabetes mellitus (DM) are common among acute coronary syndrome (ACS) patients. The present study evaluated the association between diabetes status and radial artery (RA) atherosclerosis using optical coherence tomography (OCT) in ACS patients. Methods A total of 335 ACS patients who underwent RA OCT were categorized into the DM group, the PDM group, and the normal glucose metabolism (NGM) group. OCT characteristics and clinical variables were compared. Results RA atherosclerotic plaques were more frequent in the PDM and DM groups than in the NGM group (38.7% vs. 33.3% vs. 16.1%, p = 0.001). Lipid and calcified plaque occurrence were significantly more common in the DM group, followed by the PDM and NGM groups (19.3% vs. 14.6% vs. 6.5%, p = 0.027; 11.8% vs. 6.5% vs. 1.1%, p = 0.009). The prevalence of microvessels in the PDM group was significantly higher (42.7% vs 23.7%, p = 0.017) than in the NGM group but was comparable to the DM group. Multivariate analysis revealed that HbA1c level and age were independent predictors of RA plaque formation and eccentric intimal hyperplasia (all p 〈 0.05). Conclusions RA atherosclerosis characteristics differ according to diabetes status. HbA1c level could be a useful marker for RA atherosclerosis progression in ACS patients.

Type of Medium: Online Resource

ISSN: 1479-1641 , 1752-8984

URL: Article

DOI: 10.1177/14791641221078108

Language: English

Publisher: SAGE Publications

Publication Date: 2022

detail.hit.zdb_id: 2250797-8

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Superlow Power Consumption Artificial Synapses Based on WSe 2 Quantum Dots Memristor for Neuromorphic Computing

Wang, Zhongrong ; Wang, Wei ; Liu, Pan ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2022

In: Research Vol. 2022 ( 2022-01)

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In: Research, American Association for the Advancement of Science (AAAS), Vol. 2022 ( 2022-01)

Abstract: As the emerging member of zero-dimension transition metal dichalcogenide, WSe 2 quantum dots (QDs) have been applied to memristors and exhibited better resistance switching characteristics and miniaturization size. However, low power consumption and high reliability are still challenges for WSe 2 QDs-based memristors as synaptic devices. Here, we demonstrate a high-performance, superlow power consumption memristor device with the structure of Ag/WSe 2 QDs/La 0.3 Sr 0.7 MnO 3 /SrTiO 3 . The device displays excellent resistive switching memory behavior with a R OFF / R ON ratio of ~5 × 10 3 , power consumption per switching as low as 0.16 nW, very low set, and reset voltage of ~0.52 V and~ -0.19 V with excellent cycling stability, good reproducibility, and decent data retention capability. The superlow power consumption characteristic of the device is further proved by the method of density functional theory calculation. In addition, the influence of pulse amplitude, duration, and interval was studied to gradually modulating the conductance of the device. The memristor has also been demonstrated to simulate different functions of artificial synapses, such as excitatory postsynaptic current, spike timing-dependent plasticity, long-term potentiation, long-term depression, and paired-pulse facilitation. Importantly, digit recognition ability based on the WSe 2 QDs device is evaluated through a three-layer artificial neural network, and the digit recognition accuracy after 40 times of training can reach up to 94.05%. This study paves a new way for the development of memristor devices with advanced significance for future low power neuromorphic computing.

Type of Medium: Online Resource

ISSN: 2639-5274

URL: Article

DOI: 10.34133/2022/9754876

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2022

detail.hit.zdb_id: 2949955-0

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