In:
Journal of Gastroenterology and Hepatology, Wiley, Vol. 35, No. 4 ( 2020-04), p. 634-640
Abstract:
Clear visualization of the small bowel is a requirement for satisfactory video capsule endoscopy (VCE). The aim of this study was to identify the optimal dose and timing of polyethylene glycol (PEG) for small bowel preparation before VCE. Methods A total of 410 patients were enrolled in this prospective randomized trial. All patients fasted for 12 h and ingested 320 mg simethicone 30 min before swallowing the capsule. Patients were randomized into five groups: Group A (no PEG), Group B (1‐L PEG, 12 h before VCE), Group C (2‐L PEG, 12 h before VCE), Group D (1‐L PEG, 4 h before VCE), and Group E (2‐L PEG, 4 h before VCE). The primary endpoint was small bowel visualization quality (SBVQ), and the secondary endpoints were patient acceptability and diagnosis rate of VCE. Results Excellent SBVQ was achieved in 27 (32.5%) of Group A, 38 (46.3%) of Group B, 40 (48.2%) of Group C, 55 (66.3%) of Group D, and 43 (54.4%) of Group E. The percentage of excellent SBVQ in Group D was significantly more than in Group A (66.3% vs 32.5%, P 〈 0.001), and diagnostic rate in the distal segment was higher (28.9% vs 10.8%, P = 0.0035). Patient acceptance of 1‐L PEG was better than of 2‐L PEG ( P 〈 0.005). Conclusion Small bowel cleansing with 1‐L PEG given 4 h before VCE was the optimal preparation for visualization of the bowel and patient acceptance ( ClinicalTrials.gov , ID: NCT02486536).
Type of Medium:
Online Resource
ISSN:
0815-9319
,
1440-1746
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2006782-3
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